A NOVEL OF EXPERIMENTAL MODEL FOR CENTRAL CORD INJURY ON CHRONIC SPINAL CORD COMPRESSION MODEL OF RAT. RESEARCH FOR THE TIME OF DECOMPRESSION AND CLINICAL STUDY

动物模型尚未建立新的中央脊髓损伤实验模型。在没有脊髓损伤的情况下，将一种薄的膨胀聚合物插入颈椎板下。我们研究了大鼠慢性脊髓压迫模型。我们用的是大鼠模型；我们试图研究中央脊髓损伤的机制。在我们的模型中，运动神经元计数在第9周和第25周明显减少。压迫后25周计数仅为对照组的66%。然后给出过屈曲损伤后的过伸；是否会发生上肢运动无力。我们的一些模型，有一些像中央脊髓损伤的个体。这为建立大鼠中枢脊髓损伤模型提供了可能。我们还研究了受压脊髓减压的时机。在压迫后8 ~ 12周（时间为运动神经元计数减少），如果没有实现减压，运动能力没有改善。在临床上，这一事实提示了减压手术的时机。我们将继续使用该模型和临床材料对中央脊髓损伤进行研究。我们认为该模型有助于推进对中枢脊髓损伤机制的神经病理学和神经生理学研究。

A novel experimental model for central cord injury was not developed in the animal model. A thin expanding polymer was inserted under the cervical laminae without cord injury. We have studied the chronic spinal compression model of rat. We use the model of the rat; we tried studying the mechanism of central cord injury. In our model, the motor neuron count decreased in 9 weeks and 25 weeks significantly. The count of 25 weeks after compression was only 66% compared with control group. Then, the hyperextension of hyperflexion injury was given; a motor weakness of upper extremity will happen or not. Some of our model, there were the individual like a central cord injury. The fact will give us the possibility of central cord injury model of the rat. We also investigated the timing of decompression of the compressed spinal cord. At 8 to 12 weeks after compression (the time was the motor neuron count were decreased), if the decompression was not achieved, the capability of locomotion was not improved. In clinical, the fact suggested the timing of decompression surgery. We will continue the study of central cord injury using the model and clinical material. We believe the present model is to help advancement of the neuropathological and neurophysiological studies of the mechanism of central cord injury.