A NOVEL OF EXPERIMENTAL MODEL FOR CENTRAL CORD INJURY ON CHRONIC SPINAL CORD COMPRESSION MODEL OF RAT. RESEARCH FOR THE TIME OF DECOMPRESSION AND CLINICAL STUDY

大鼠慢性脊髓受压模型中枢性脊髓损伤实验模型的新颖性。

• 批准号: 13671460
• 负责人: KAWAMOTO Toshiki
• 金额: $ 2.05万
• 依托单位: DOKKYO UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671460/
• 关键词: chronic cord compression; spinal cord; neuronal loss; rat; central cord injury; microvascular anatomy; compression myelopathy; acute spinal injury; acute spinal injury; chronic spinal cord compression; central cord injury; neuronal loss; apopt

A novel experimental model for central cord injury was not developed in the animal model. A thin expanding polymer was inserted under the cervical laminae without cord injury. We have studied the chronic spinal compression model of rat. We use the model of the rat; we tried studying the mechanism of central cord injury. In our model, the motor neuron count decreased in 9 weeks and 25 weeks significantly. The count of 25 weeks after compression was only 66% compared with control group. Then, the hyperextension of hyperflexion injury was given; a motor weakness of upper extremity will happen or not. Some of our model, there were the individual like a central cord injury. The fact will give us the possibility of central cord injury model of the rat. We also investigated the timing of decompression of the compressed spinal cord. At 8 to 12 weeks after compression (the time was the motor neuron count were decreased), if the decompression was not achieved, the capability of locomotion was not improved. In clinical, the fact suggested the timing of decompression surgery. We will continue the study of central cord injury using the model and clinical material. We believe the present model is to help advancement of the neuropathological and neurophysiological studies of the mechanism of central cord injury.

在动物模型中没有开发出用于中央脊髓损伤的新实验模型。在无脊髓损伤的情况下，将一个薄的可膨胀聚合物插入颈椎椎板下。本研究建立了大鼠慢性脊柱压迫模型。本实验采用大鼠脊髓损伤模型，对脊髓损伤的机制进行了初步的探讨。在我们的模型中，运动神经元计数在9周和25周显著减少。压迫后25周计数仅为对照组的66%。然后，给出过伸过屈损伤，是否会发生上肢运动无力。我们的一些模型中，有个别像是中央脊髓损伤。这一事实为建立大鼠脊髓损伤模型提供了可能。我们还研究了压迫脊髓的减压时机。压迫后8 ~ 12周（运动神经元计数减少的时间），如果不减压，运动能力没有改善。在临床上，这一事实提示了减压手术的时机。我们将继续使用该模型和临床材料进行中央脊髓损伤的研究。我们相信，本模型有助于促进中枢脊髓损伤机制的神经病理学和神经生理学研究。