Technology-driven combinatorial therapy to rewire the spinal cord after injury (ReWire)

技术驱动的组合疗法可在损伤后重新连接脊髓 (ReWire)

• 批准号: EP/X031497/1
• 负责人: Elizabeth Bradbury
• 金额: $ 33.8万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FX031497%2F1
• 关键词: Technology; driven; combinatorial; therapy; rewire

ReWIRE will combine innovative translational neurotechnologies and rehabilitation interventions for the repair and restoration of neurological functions following injury of the spinal cord (SC). The proposed research program will equip next-generation scientists with unique skills to develop disruptive therapeutic solutions for patients with paralysis. Recent technological breakthroughs have triggered a paradigm shift in the conception of therapies aimed to restore function after spinal cord injury (SCI). Novel drug delivery systems and biomaterial bridges have been engineered to reduce secondary injury and scarring, to stimulate and guide regenerating nerve fibres across the lesion site, and to promote functional reconnection with intact tissue. Additionally, neuromodulation therapies can reactivate spinal circuits below a SCI, allowing people with chronic paralysis to regain voluntary control of walking. In conjunction with rehabilitation, neurological recovery was promoted that persisted without neuromodulation, suggesting a rewiring of the SC as demonstrated in preclinical models. To bypass an injury, neuromodulation has been linked to brain signals to re-establish corticalcontrol over spinal circuits by employing electrical nerve stimulation and robotic systems. Advances in robotics are significantly augmenting the impact of neurorehabilitation by inducing new natural "wired" connections. The aim of ReWIRE is to leverage all these technical and therapeutic breakthroughs in the framework of multiple PhD projects that will continuously interact to converge toward effective combinatorial treatments for SCI. ReWIRE will focus on three inter-woven objectives: i) establish an international, interdisciplinary, and intersectoral educational network, ii) build an SCI clinical data platform, and, iii) position Europe at the forefront of therapy for SCI.

ReWIRE将联合收割机结合创新的转化神经技术和康复干预，用于修复和恢复脊髓（SC）损伤后的神经功能。拟议的研究计划将为下一代科学家提供独特的技能，为瘫痪患者开发颠覆性的治疗方案。最近的技术突破引发了旨在恢复脊髓损伤（SCI）后功能的治疗概念的范式转变。新型药物输送系统和生物材料桥已经被设计用于减少继发性损伤和瘢痕形成，刺激和引导再生神经纤维穿过损伤部位，并促进与完整组织的功能重新连接。此外，神经调节疗法可以重新激活SCI以下的脊髓回路，使慢性瘫痪患者重新获得对行走的自主控制。结合康复，促进了神经恢复，在没有神经调节的情况下持续存在，表明SC的重新布线，如临床前模型所示。为了绕过损伤，神经调节已经与大脑信号联系起来，通过采用电神经刺激和机器人系统来重建对脊髓回路的皮质控制。机器人技术的进步通过诱导新的自然“有线”连接来显著增强神经康复的影响。ReWIRE的目标是在多个博士项目的框架内利用所有这些技术和治疗突破，这些项目将不断相互作用，以汇聚为SCI的有效组合治疗方法。ReWIRE将专注于三个相互交织的目标：i）建立国际，跨学科和跨部门的教育网络，ii）建立SCI临床数据平台，iii）将欧洲置于SCI治疗的最前沿。