Effect of hyaluronic acid on the excursion resistance of flexor tendon, tendon sheath reconstruction.

透明质酸对屈肌腱偏移阻力、腱鞘重建的影响。

• 批准号: 13671538
• 负责人: NISHIDA Jun
• 金额: $ 1.09万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671538/
• 关键词: gliding resistance; Hyaluronic acid; teurorrhaphy; tenorrhaphy; 腱・腱鞘; 滑動抵抗; ヒアルロン酸; Sxluusio., nesistams; fendon; pulley

Adhesion between the tendon and tendon sheath after primary flexor tendon repair is seen frequently, and postoperative finger function is occasionally unsatisfactory. A reduction of the friction may facilitate tendon mobilization, which in turn may reduce the risk of the adhesion and restriction of range of motion. We considered the possibility of utilizing the hyaluronic acid (HA) as a lubricant. To evaluate the effect of HA, the gliding resistance between the canine flexor digitorum profundus tendon repaired by a modified Kessler suture technique with running epitendinous suture and the annular pulley located on the proximal phalanx (corresponding to the A2 pulley in humans) was evaluated and compared before and after administration of HA. The HA solution measurement groups were identified as follows; intact tendon as a control; repaired tendon; tendon soaked in 0.1, 1, and 10 mg/mI HA. The resistance increased after repairing, then it decreased after soaking in 10 mg/ml HA solution. The results of this study revealed that HA diminishes the excursion resistance after flexor tendon repair. We believe that some style of administration of the HA might reduce the excursion resistance and prevent adhesion until the synovial surface is fully developed.

原发性屈肌腱修复后肌腱与腱鞘粘连是常见的，术后手指功能偶尔不令人满意。摩擦力的减少可以促进肌腱活动，这反过来可以降低粘连和活动范围限制的风险。我们考虑了利用透明质酸（HA）作为润滑剂的可能性。为了评价HA的作用，评价并比较了HA给药前后采用改良Kessler缝合技术（带连续腱外膜缝合）修复的犬趾深屈肌腱与位于近节指骨上的环形滑轮（对应于人类的A2滑轮）之间的滑动阻力。HA溶液测量组确定如下：完整肌腱作为对照;修复肌腱;浸泡在0.1、1和10 mg/ml HA中的肌腱。修复后电阻增加，10 mg/ml HA溶液浸泡后电阻降低。这项研究的结果表明，HA减少了屈肌腱修复后的偏移阻力。我们认为，HA的某些给药方式可能会降低漂移阻力，并防止粘连，直到滑膜表面完全发育。

项目成果

Effect of hyaluronic acid on the excursion resistance of tendon grafts

透明质酸对肌腱移植物抗偏移性的影响

• 发表时间: 2004
• 期刊: J.Bone Joint Surg. 86・B
• 作者: Akasaka T;Nishida J;et al.;Nishida J et al.
• 通讯作者: Nishida J et al.

荒木信吾, 西田淳, 赤坂俊樹: "犬における腱-腱鞘間滑動抵抗に対するヒアルロン酸の影響"岩手医学雑誌. 54・5. 373-380 (2002)

Shingo Araki、Jun Nishida、Toshiki Akasaka：“透明质酸对狗肌腱鞘滑动阻力的影响”岩手医学杂志 54・5（2002 年）。

Hyaluronic acid diminishes the resistanca to excursion after flexor tendon repair : An in vitro biomechanical study

透明质酸减少屈肌腱修复后的偏移抵抗力：一项体外生物力学研究

• 发表时间: 2005
• 期刊: J.Biomechanics 38
• 作者: Akasaka T;Nishida J;et al.
• 通讯作者: et al.

Effect of hyaluronic acid on the excursion resistance of flexor tendon grafts.

透明质酸对屈肌腱移植物抗偏移性的影响。

• 发表时间: 2004
• 期刊: J.Bone Joint Sung. 86-B
• 作者: Nishida;J.;et al.
• 通讯作者: et al.

Hyaluronic acid diminishes the resistance to excursion after flexor tendon repair: An in vitro biomechanical study

• DOI: 10.1016/j.jbiomech.2004.04.021
• 发表时间: 2005-03-01
• 期刊: JOURNAL OF BIOMECHANICS
• 影响因子: 2.4
• 作者: Akasaka, T;Nishida, J;An, KN
• 通讯作者: An, KN