Analysis of molecular signal transduction pathway between M-CSF and c-fms involved in uterine cervical cancer

M-CSF与c-fms参与宫颈癌的分子信号转导通路分析

• 批准号: 13671744
• 负责人: SUZUKI Nao
• 金额: $ 2.24万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13671744/
• 关键词: Uterine Cervical Cancer; Differentiation; M-CSF; c-fms; HCG; hCG

Human chorionic gonadotoropin (HCG) is a glycoprotein hormone normally produced by placenta during pregnancy. It is also well known that HCG is produced ectopicafly by many nontrophoblastic neoplasms including uterine cervical carcinoma. On the other hand, we have reported that macrophage colony-stimulating factor (M-CSF), and c-fms, a receptor tyrosine kinase for M-CSF play important functional roles in the differentiation of a human embryonal carcinoma cell line, NCR-G3 (G3) cells into trophoectoderm which produce HCG retinoic acid (RA) treatment. In this study, we investigated the relationship between ectopic production of HCG and signal transduction pathway of MCF and c-fms in uterine cervical carcinoma using uterine carcinoma cell lines (SKG-I, SKG-II, SKG-IIIa, SKG-IIIb) established in our laboratory. As a result, unfortunately we could not find out the mechanism of ectopic production of HCG in relation to the signal transduction of M-CSF and c-fms in uterine cervical carcinoma

人绒毛膜促性腺激素（HCG）是一种糖蛋白激素，通常在妊娠期间由胎盘产生。众所周知，许多非滋养层肿瘤（包括宫颈癌）都能异位产生HCG。另一方面，我们已经报道了巨噬细胞集落刺激因子（M-CSF）和C-fms（M-CSF的受体酪氨酸激酶）在人胚胎癌细胞系NCR-G3（G3）细胞向滋养外胚层分化中发挥重要的功能作用，所述滋养外胚层产生HCG视黄酸（RA）处理。本研究利用本实验室建立的子宫颈癌细胞系（SKG-I、SKG-II、SKG-IIIa、SKG-IIIb），探讨子宫颈癌中HCG异位分泌与MCF和c-fms信号转导通路的关系。因此，我们未能从M-CSF和c-fms信号转导的角度探讨子宫颈癌中HCG异位产生的机制