Analysis of molecular signal transduction pathway between M-CSF and c-fms involved in uterine cervical cancer

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Human chorionic gonadotoropin (HCG) is a glycoprotein hormone normally produced by placenta during pregnancy. It is also well known that HCG is produced ectopicafly by many nontrophoblastic neoplasms including uterine cervical carcinoma. On the other hand, we have reported that macrophage colony-stimulating factor (M-CSF), and c-fms, a receptor tyrosine kinase for M-CSF play important functional roles in the differentiation of a human embryonal carcinoma cell line, NCR-G3 (G3) cells into trophoectoderm which produce HCG retinoic acid (RA) treatment. In this study, we investigated the relationship between ectopic production of HCG and signal transduction pathway of MCF and c-fms in uterine cervical carcinoma using uterine carcinoma cell lines (SKG-I, SKG-II, SKG-IIIa, SKG-IIIb) established in our laboratory. As a result, unfortunately we could not find out the mechanism of ectopic production of HCG in relation to the signal transduction of M-CSF and c-fms in uterine cervical carcinoma