Treatment of dentin hypersensitivity and dental caries by ammonium hexafluorosilicate

六氟硅酸铵治疗牙本质过敏和龋齿

• 批准号: 13672002
• 负责人: SUGE Toshiyuki
• 金额: $ 2.24万
• 依托单位: Tokushima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672002/
• 关键词: Demineralization; Bovine tooth; Ammonium hexafluorosilicate; Dental caries; Microradiography; Diamine silver fluoride; Fluoride; Dentin hypersensitivity; 表面粗さ測定器; サホライド; 象牙質透過性; 走査電子顕微鏡; 象牙細管

Diamine silver fluoride is clinically used to prevent progress of dental caries in Japan. However, diamaine silver fluoride stains teeth black due to silver sulfide precipitation. To solve this drawback, we prepared ammonium hexafluorosilicate which dose not stain teeth, and we found ammonium hexafluorosilicate increased crystallinity of apatite powder and formed lager amount of fluoridated apatite when compared with acidulated phosphate fluoride (APF) or diamine silver flioride. The aim of this study was to evaluate whether or not ammonium hexafluorosilicate increase acid resistance of bovine enamel and dentin. Bovaine enamel and dentin ware embedded into resin leaving labial side exposed. The polished surface was divided into several portions using paraffin wax and each portion was treated with a fluoride solution (ammonium hexafluorosilicate, diamine silver fluoride, APF or NaF) for 3 min. after the fluoride solutions were washed out with distilled water, the tooth was immersed in d … More emineralization solution for 24 hours. The depth of demineralized tooth was measured with surface roughness analyzer. Also, the demineralized specimens were subjected microradiography. In the enamel specimens, demineralized depth after treated with ammonium hexafluorosilicate (81.6%) or diamine silver fluoride (83.7%) was significantly shallower than that of control {98.6^^+__- 40.0um(100%)}. Treatment with APF or NaF did not reduce the depth significantly. All fluoride solutions reduced the depth than that of control in dentin specimens. Diamine silver fluoride (75.5%) and ammonium hexafluorosilicate (85.2%) treatments showed greater acid resistance than the layer formed after ammonium hexafluorosilicate od diamine silver fluoride treatment prevented progress of demineralization. We concluded that ammonium hexafluorosilicate is useful to prevent enamel and caries since ammonium hexafluorosilicate trearment increased acid resistance of enamel and dentin without changing the color of tooth. Less

二胺氟化银在日本临床上用于预防龋齿进展。然而，由于硫化银的沉淀，二胺氟化银会使牙齿染黑。为了解决这一问题，我们制备了不染牙的六氟硅酸铵，并发现与酸化的氟化磷(APF)或二胺氟化银相比，六氟硅酸铵提高了磷灰石粉末的结晶度，形成了更多的氟化磷灰石。本研究的目的是评价六氟硅酸铵是否能提高牛牙釉质和牙本质的耐酸性。牛因牙釉质和牙本质镶嵌在树脂中，使唇侧暴露。用石蜡将抛光表面分成几部分，每一部分用氟化钠溶液(六氟硅酸铵、二胺氟化银、APF或NaF)处理3min。氟化物溶液用蒸馏水冲洗后，将牙齿浸泡在d…中。24小时更多的脱矿溶液。用表面粗糙度分析仪测量脱矿牙深度。同时，对脱矿标本进行了显微放射照相。在牙釉质标本中，经六氟硅酸铵(81.6%)或二胺氟化银(83.7%)处理后的脱矿深度明显低于对照组(98.6^+40.0um(100%))。APF或NaF处理均未显著降低牙周深度。所有氟化物溶液在牙本质标本中的深度均小于对照组。二胺氟化银(75.5%)和六氟硅酸铵(85.2%)处理后的脱矿层比六氟硅酸铵处理后形成的脱矿层具有更强的耐酸性。结论：六氟硅酸铵处理后，在不改变牙齿颜色的前提下，提高了牙釉质和牙本质的耐酸性，有利于预防牙釉质和龋病的发生。较少

项目成果

A.Kawasaki et al,: "Effects of ammonium hexafluorosilicate on occlusion of dentinal tubules"Journal of Dental Research. 80 (Special issue). 750 (2001)

A.Kawasaki 等人：“六氟硅酸铵对牙本质小管闭塞的影响”牙科研究杂志。

T.Suge et al,: "CaCl_2 increase dentinal tubules occlusion ability of potassium oxalate treatment"Journal of Dental Research. 80 (Special issue). 750 (2001)

T.Suge等人：“草酸钾治疗CaCl_2增加牙本质小管闭塞能力”Journal of Dental Research。

A.Kawasaki et al,: "Effects of plaque control on the patency and occlusion of dentine tubules in situ"Journal of Orai Rehabilitation. 28(5). 439-449 (2001)

A.Kawasaki 等人：“牙菌斑控制对原位牙本质小管的通畅和闭塞的影响”Orai 康复杂志。

T.Suge et al,: "Calcium phosphate precipitation method for the treatment of dentin hypersensitivity"American Journal of Dentistry. 15(4). 220-226 (2002)

T.Suge等人：“磷酸钙沉淀法治疗牙本质过敏”美国牙科杂志。

T.SUGE et al.: "Calcium phosphate precipitation method for the treatment of dentin hypersensitivity"American Journal of Dentistry. 15・4. 220-226 (2002)

T. SUGE等：“治疗牙本质过敏的磷酸钙沉淀法”美国牙科杂志15・4（2002年）。