Development of the method for prevention of dental caries with antibacterial ammonium hexafluorosilicate

抗菌六氟硅酸铵防龋方法的研制

• 批准号: 22592121
• 负责人: SUGE Toshiyuki
• 金额: $ 2.83万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22592121/
• 关键词: スメア層; フッ化ジアミンシリケート; フッ化ジアンミン銀; フッ素; 抗菌成分; 象牙細管; 齲蝕; ハイドロキシアパタイト; 塩化セチルピリジニウム; 粉末Ｘ線回折; 齲蝕予防; S. mutans

Diamine silver fluoride (Saforide) is clinical use for prevent of progress of dental caries and desensitizing for hypersensitive tooth. Unfortunately, diamine silver fluoride stained tooth black due to silver deposition. To overcome this drawback, ammonium hexafluorosilicatewas prepared. Comparing the antibacterial activity, ammonium hexafluorosilicate seems to be inferior to diamine silver fluoride. To increase the antibacterial activity of ammonium hexafluorosilicate, several antibacterial agents have been added to ammonium hexafluorosilicate solution. The antibacterial activity of ammonium hexafluorosilicate with the addition of antibacterial agents was increased, therefore, ammonium hexafluorosilicate is useful for prevention of dental caries.

二胺氟化银在临床上用于预防龋齿的发展和对过敏牙齿的脱敏。不幸的是，由于银沉积，二胺氟化银会使牙齿变黑。为了克服这一缺点，制备了六氟硅酸铵。六氟硅酸铵的抑菌活性似乎不如二胺氟化银。为了提高六氟硅酸铵的抑菌活性，在六氟硅酸铵溶液中加入了几种抗菌剂。加入抗菌剂后，六氟硅酸铵的抑菌活性增强，因此，六氟硅酸铵可用于预防龋齿。

项目成果

Changes of crystallinity of hydroxyapatite powder and structure of enamel treated with several concentrations of ammonium hexafluorosilicate

不同浓度六氟硅酸铵处理羟基磷灰石粉结晶度及釉质结构的变化

• 发表时间: 2011
• 作者: Yamanaka;et al.;Y.Yoshida;Suge T
• 通讯作者: Suge T

Reinforcement of bond strength of self-etching orthodontic adhesive

自酸蚀正畸粘合剂粘合强度的增强

• DOI: 10.2319/012011-39.1
• 发表时间: 2012
• 期刊: The Angle Orthodontist
• 作者: Horiuchi S;Kuroda S;Hiasa M;Suge T;Saku S;Hamada K;Matsuo T;Asaoka K;Tanaka E
• 通讯作者: Tanaka E

Occlusion of dentin tubules with antibacterial ammonium hexafluorosilicate solution for the prevention of dentin caries

抗菌六氟硅酸铵溶液封闭牙本质小管预防牙本质龋病

• 发表时间: 2011
• 期刊: American Journal of Dentistry
• 影响因子: 1.4
• 作者: Shibata S;Suge T;Ishikawa K;Matsuo T
• 通讯作者: Matsuo T

Ammonium hexafluorosilicate with antimicrobial agents for the prevention of caries

六氟硅酸铵与抗菌剂预防龋齿

• 发表时间: 2012
• 作者: Cardoso MV;Chaudhari A;Yoshida Y;Van Meerbeek B;Naert I;Duyck J;Suge T;Hosoya A et al.;韓 臨麟;Ohkura N et al;Matsuo T
• 通讯作者: Matsuo T

Antibacterial activity of ammonium hexafluorosilicate solution with antimicrobial agents for the prevention of dentin caries

含抗菌剂的六氟硅酸铵溶液预防牙本质龋病的抗菌活性

• 发表时间: 2012
• 期刊: American Journal of Dentistry
• 影响因子: 1.4
• 作者: SHINGO SHIBATA;TOSHIYUKI SUGE;TOMOKO KIMURA;KUNIO ISHIKAWA;& TAKASHI MATSUO
• 通讯作者: & TAKASHI MATSUO