Pathogen enzyme productivity of bacteria isolated from a therapy resistant periapical periodontitis cases

从治疗耐药的根尖周炎病例中分离出的细菌的病原体酶生产力

• 批准号: 13672017
• 负责人: YOSHIDA Masahiro
• 金额: $ 0.9万
• 依托单位: Osaka Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672017/
• 关键词: therapy-restant periodontis; Enterococcs faecalis; Pseudomonas aeruginosa; Streptococcus oralis; Pathogen enzyme productivity; chondroitin sulfatase; collagenase; hyaluronidase; Candida; 組織侵襲性; 病原性; チェアーサイド嫌気培養システム; 抗菌薬局所投与; Candida albicans

Refractory periapical periodontitis is caused by persistent infection by bacteria to resist for endodontic treatment such as Enterococcs faecalis, Candida albicans, Pseudomonas aeruginosa and Streptococcus oralis.Many of refractory periapical periodontitis cases are subacute cases, but those symptom is various.The bacteria which resisted therapy examined productivity in pathogen enzyme for the purpose of it was clear, and in this study, these doing the effect which therapy resistant bacteria gave to clinical manifestation expression of a refractory periapical periodontitis case.The type strain (ATCC35039) and the test strain of S.oralis did hot show pathogen enzyme production characteristics.E.faecalis showed chondoroitin sulfatase producing.P.aeruginosa showed lecithinase producing and weak producing such as collagenase, hyaluronidase and chondoroitin sulfatase in high frequency.These resultant showed the probability which pathogen enzyme production characteristics of these bacteria participated in refractory periapical periodontitis developing for clinical symptom persistently.

耐火核核牙周炎是由细菌持续感染抗牙髓治疗的原因引起的出于目的的目的，酶很明显，在这项研究中，这些具有耐药细菌对临床表达表达的作用的作用。类型菌株（ATCC35039）和S.oralis的测试菌株确实热显示病原体生产特征。卵他酶产生和产生弱的产生，例如胶原酶，透明质酸酶和软骨蛋白硫酸酶，以高频。这些结果表明，这些细菌的病原体生产特征参与了持续性临床症状。

项目成果

吉田 匡宏: "難治症例を治す"歯科医学. 64(1). 66-71 (2001)

Masahiro Yoshida：“治疗疑难病例”牙科 64(1) (2001)。