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Neurotrophic effects of Radicicol on Sensory Neurons

Neurotrophic effects of Radicicol on Sensory Neurons
根底考对感觉神经元的神经营养作用
批准号:
13680848
负责人:
SANO Mamoru
金额:
$2.37万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2003

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中文摘要
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英文摘要
Radicicol and geldanamycin, Hsp9O-binding antibiotics, potentiate neurite growth and survival of cultured sensory neurons from chick embryo. They did not exhibit trophic effects on the sensory neurons from embryonic and adult rats and mice. We show that the antibiotics induced the outgrowth of neurites in NG108-15 cells and N2A cells. Treatment of cells with these drugs decreased levels of Raf1,ERK1/2 and phosphorylated ERK1/2 time-dependently. Levels of Akt1 and CDK4 were slightly decreased. The neurite growth by the drugs was blocked by actynomycin D. The neurite growth of NG108-15 cells Geld might be due to a change in the synthesis of some specific protein(s).
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Sakuma K.: "Serum response factor plays an important role in the mechanically overloaded plantaris muscle of rats"Histochem.Cell Biol.. 119. 149-160 (2003)
Sakuma K.:“血清反应因子在大鼠机械超负荷的跖肌中发挥重要作用”Histochem.Cell Biol.. 119. 149-160 (2003)
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Sakuma, K.: "Serum response factor plays an important role in the mechanically overloaded plantaris muscle of rats."Histochem. Cell Biol.. 119. 149-160 (2003)
Sakuma, K.:“血清反应因子在大鼠机械超负荷的跖肌中发挥着重要作用。”Histochem。
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Sakuma K.: "Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2"Acta Neuropathologica. 105. 271-280 (2003)
Sakuma K.:“钙调神经磷酸酶是骨骼肌再生的有效调节剂,与 NFATc1 和 GATA-2 相关”《神经病理学报》。
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Sakuma K.: "Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2"Acta Neurophathologica. 105. 271-280 (2003)
Sakuma K.:“钙调神经磷酸酶是骨骼肌再生的有效调节剂,与 NFATc1 和 GATA-2 相关”《神经病理学学报》。
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7
    Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo.
    • 批准号:
      10680735
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.98万
    • 财政年份:
      1998
    • 负责人:
      SANO Mamoru
    • 依托单位:
    NGF-Induced Neurite Outgrowth from PC12 cells and MAP Kinase
    Studies on the local control by nerve growth factor of the outgrowth of neurites in PC12D cells.
    MANAGEMENT PHILOSOPHIES AND THE ORGANIZATIONAL CLIMATE AND CULTURE IN JAPANESE AND AMERICAN CORPORATIONS
    • 批准号:
      05044026
    • 项目类别:
      Grant-in-Aid for international Scientific Research
    • 资助金额:
      $9.6万
    • 财政年份:
      1993
    • 负责人:
      SANO Mamoru
    • 依托单位:
    国内基金
    海外基金
    格尔德霉素前体PKS后修饰的新途径与生物学改造的研究
    • 批准号:
      30801447
    • 项目类别:
      青年科学基金项目
    • 资助金额:
      20.0万元
    • 批准年份:
      2008
    • 负责人:
      赫卫清
    • 依托单位:
    Geldanamycin抗癌前药的设计、合成及其药效研究
    格尔德霉素抗单纯疱疹病毒1型的分子机制研究
    • 批准号:
      30572216
    • 项目类别:
      面上项目
    • 资助金额:
      30.0万元
    • 批准年份:
      2005
    • 负责人:
      李玉环
    • 依托单位: