Neurotrophic effects of Radicicol on Sensory Neurons
Neurotrophic effects of Radicicol on Sensory Neurons
批准号:
13680848
负责人:
SANO Mamoru
金额:
$2.37万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2003
中文摘要
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英文摘要
Radicicol and geldanamycin, Hsp9O-binding antibiotics, potentiate neurite growth and survival of cultured sensory neurons from chick embryo. They did not exhibit trophic effects on the sensory neurons from embryonic and adult rats and mice. We show that the antibiotics induced the outgrowth of neurites in NG108-15 cells and N2A cells. Treatment of cells with these drugs decreased levels of Raf1,ERK1/2 and phosphorylated ERK1/2 time-dependently. Levels of Akt1 and CDK4 were slightly decreased. The neurite growth by the drugs was blocked by actynomycin D. The neurite growth of NG108-15 cells Geld might be due to a change in the synthesis of some specific protein(s).
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Sakuma K.: "Serum response factor plays an important role in the mechanically overloaded plantaris muscle of rats"Histochem.Cell Biol.. 119. 149-160 (2003)
Sakuma K.:“血清反应因子在大鼠机械超负荷的跖肌中发挥重要作用”Histochem.Cell Biol.. 119. 149-160 (2003)
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Sakuma, K.: "Serum response factor plays an important role in the mechanically overloaded plantaris muscle of rats."Histochem. Cell Biol.. 119. 149-160 (2003)
Sakuma, K.:“血清反应因子在大鼠机械超负荷的跖肌中发挥着重要作用。”Histochem。
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Sakuma K.: "Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2"Acta Neuropathologica. 105. 271-280 (2003)
Sakuma K.:“钙调神经磷酸酶是骨骼肌再生的有效调节剂,与 NFATc1 和 GATA-2 相关”《神经病理学报》。
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Sakuma K.: "Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2"Acta Neurophathologica. 105. 271-280 (2003)
Sakuma K.:“钙调神经磷酸酶是骨骼肌再生的有效调节剂,与 NFATc1 和 GATA-2 相关”《神经病理学学报》。
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Ishikawa, T.: "Peroxisomes exist in growth cones and move anterogradely and retrogradely in neurites of PC12D cells."Exp. Cell Res.. 266. 260-269 (2001)
Ishikawa, T.:“过氧化物酶体存在于生长锥中,并在 PC12D 细胞的神经突中顺行和逆行移动。”
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共 7 条
Radicicol potentiates neurotrophin-mediated neurite outgrowth and survival of cultured sensory neurons from chick embryo.
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Nerve Growth Factor-Induced Neurite Outgrowth and MAP Kinase
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