The cellular mechanism of ischemic tolerance in hippocampus

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1) Development of Adeno-assiciated virus: AAV is a potentially useful gene transfer vehicle for neurological gene therapies. Recent findings have shown that recombinant AAV type 5 (rAAV5) can efficiently transduce both neuronal cells and glial cells, while eAAV2 preferentially transduces neuronal cells. Cerebral parenchyaml gene transduction by rAVV5 is more diffuse and widespread compared to transduction by rAAV2.2) Ischemic tolerance in developing brain: By using heterotopic brain graft model, we have made histological and electrophysiological studies of the infant rat brain after prolonged ischemia (90-120min). Our results are consistent with data indicating that deep hypothermia has a notable neuroprotective effect on ischemic injury.