NEURONAL ACTIVITY IN THE PREFRONTAL CORTEX IN RELATION TO SEQUENTIAL PERFORMANCE OF CATEGORIZED MULTIPLE MOVEMENTS

前额叶皮层中与分类多项运动的顺序执行相关的神经元活动

• 批准号: 13680891
• 负责人: SHIMA Keisetsu
• 金额: $ 2.11万
• 依托单位: Tohoku university
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680891/
• 关键词: Categorization; Unit activity; Prefrontal cortex; Monkey; ニホンザル

The purpose of the present study was to examine how neuronal activity in the prefrontal cortex is involved in performance of categorized multiple movements. We trained a monkey to perform four movements sequentially, separated by brief waiting periods. In one condition, a visual signal (LED of three different colors) indicated what movement to be performed. In the other condition, correct sequences of fore movements had to be remembered. EMG analyses showed that magnitude of muscle activities were equal in the two conditions. Activity change in forelimb muscle were not detectable during waiting periods. Animal was performed 11 kinds of multiple movements, which are categorized in three patterns; mono-series type (push-push-push-push, pull-pull-pull-pull, turn-turn-turn-turn), alternate series type (push-turn-push-turn, pull-turn-pull-turn, turn-push-turn-push, turn-pull-turn-pull), and paired series type (push-push-turn-turn, pull-pull-turn-turn, tunr-turn-push-push, turn-turn-pull-pull).241 task-related neurons were recorded in the prefrontal cortex. Among them 77 neurons shdwed increased activity in first waiting period. 53 of 77 neurons were belonged to the one of three patterns; mono-series type 11; alternate series type 23; paired series type 19. Many neurons were recorded in and around the principal sulcus, especially in the upper part of principal snlcus. Such activities were not recorded in frontal eye field. These results indicate prefrontal cortex participate in categorization of sequential performance of multiple movements

本研究的目的是检查前额皮质中的神经元活动如何参与分类多重运动的表现。我们训练一只猴子依次执行四个动作，中间间隔短暂的等待时间。在一种情况下，视觉信号（三种不同颜色的 LED）指示要执行的动作。在另一种情况下，必须记住正确的前部动作顺序。肌电图分析表明，两种情况下肌肉活动的强度相同。在等待期间未检测到前肢肌肉的活动变化。动物进行了11种多重动作，分为三种模式；单系列型（推-推-推-推、拉-拉-拉-拉、转-转-转-转）、交替系列型（推-转-推-转、拉-转-拉-转、转-推-转-推、转-拉-转-拉）和配对系列型（推-推-转-转、拉-拉-转-转、 tunr-转-推-推，转-转-拉-拉).241 任务相关 记录了前额叶皮层的神经元。其中 77 个神经元在第一个等待期表现出活动增加。 77 个神经元中有 53 个属于三种模式之一；单系列 11 型；备用系列类型 23；配对系列类型19。在主沟内及其周围记录到许多神经元，特别是在主沟的上部。额眼视野中没有记录此类活动。这些结果表明前额叶皮层参与多种运动的顺序表现的分类

项目成果

Wang, Y, Shima, K., Sawamura, H., Tanji, J.: "Spatial Distribution of Cingulate Cells Projecting to the Primary, Supplementary, and Pre-supplymentary Motor Areas : A Retrograde Multiple Labeling Study in the Macaque Monkey"Neurosci. Res.. 39. 39-49 (2001)

Wang, Y, Shima, K., Sawamura, H., Tanji, J.：“投射到初级、补充和预补充运动区的扣带细胞的空间分布：猕猴的逆行多重标记研究”Neurosci

Tanji, J., Shima, K., Matsuzaka, Y.: "Reward-based planning of motor selection in the rostral cingulate motor area"Adv.Exp.Med.Biol.. 508. 417-423 (2002)

Tanji, J.、Shima, K.、Matsuzaka, Y.：“头侧扣带运动区运动选择的基于奖励的规划”Adv.Exp.Med.Biol.. 508. 417-423 (2002)

Sawamura, H., Shima, K., Tanji, J.: "Numerical representation for action in the parietal cortex of the monkey"Nature. 415. 918-922 (2002)

Sawamura, H.、Shima, K.、Tanji, J.：“猴子顶叶皮层作用的数值表示”《自然》。

Tanji,J., Shima,K., Matsuzaka,Y.: "Reward-based planning of motor selection in the rostral cingulate motor area"Adv. Exp. Med. Biol.. 508. 417-423 (2002)

Tanji,J.、Shima,K.、Matsuzaka,Y.：“头侧扣带回运动区运动选择的基于奖励的规划”Adv。

Wang, Y, Shima, K., Isoda M., Sawamura, H., Tanji, J.: "Spatial Distribution and density of prefrontal cortical cell sprojecting to three sectors of the premotor cortex"NeuroReport. 13. 1341-1344 (2002)

Wang, Y, Shima, K., Isoda M., Sawamura, H., Tanji, J.：“投射到前运动皮层三个部分的前额皮质细胞的空间分布和密度”NeuroReport。