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Role for cells in the cingulate motor area of the monkey

猴子扣带回运动区细胞的作用

基本信息

批准号：
08680880
负责人：
SHIMA Keisetsu
金额：
$ 1.54万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08680880/
关键词：
cingulate motor area monkey motor task unit activity

项目摘要

The purpose of the present study was to examine how neuronal activity in the rostral cingulate motor area (CMAr) is involved in the movenent alteration based on the evaluation of reward. Two monkeys (Macaca fuscata) were trained to perform two different arm movements (turn or pull a handle), in response to visual trigger signal (LED). Each movement was started from a neutral position. Initially, the monkey has to guess which of two movements was correct. The correct movement was rewarded with a drop of fruit juice (0.1ml). The correct movememt was not changed during in a block of trials (5-11 trials of constant-reward), requiring the monkeys to keep selecting the same movement. Thereafter, the amount of reward was progressively decreased by 30% per trial, if the monkey repeated the same movement. At this stage of the behavioral time schedule, the monkeys were free to select a alternative movement. If they did movement alteration, the alternative movement was now defined as a correct movement. The amount of reword came back to its full amount, and a new series of the constant-reward trials begun. In CMAr, about 28% of task-related neurons were active during a interval between the occurrence of reduced reward and the initiation of a selected movement that was different from a previously performed movement. Remaining neurons were active in relation to movement initiation or during a period of preparation for a next movement. In contrast, cells in the caudal cingulate motor area (CMAc) and in the primary motor cortex (MI) were mostly related to the execution of movement or motor preparation. Only small number of CMAc cells (3%) and MI cells (1%) exhibited activity related to motor selection. These observations indicate that the CMAr plays a role in motor alteration or motor selection based on the reward evaluation. On the other hand, neither the CMAc and the MI are the cortical sites where the reward information is processed for the purpose of motor selection.

本研究的目的是探讨喙扣带运动区（CMAr）的神经元活动是如何参与基于奖赏评价的运动改变的。训练两只猴子（Macaca fuscata）响应视觉触发信号（LED）执行两种不同的手臂运动（转动或拉动手柄）。每个动作都是从中立位置开始的。最初，猴子必须猜测两个动作中哪一个是正确的。正确的动作奖励一滴果汁（0.1毫升）。正确的动作在一组试验（5-11次恒定奖励试验）中没有改变，要求猴子继续选择相同的动作。此后，如果猴子重复相同的动作，每次试验的奖励量逐渐减少30%。在行为时间表的这个阶段，猴子可以自由选择另一种运动。如果他们做了运动改变，那么替代运动现在被定义为正确运动。重新输入的数量回到了它的全部数量，一系列新的恒定奖励试验开始了。在CMAr中，大约28%的任务相关神经元在奖励减少的发生和与先前执行的运动不同的选定运动的开始之间的间隔期间是活跃的。剩余的神经元在运动开始或准备下一个运动的一段时间内是活跃的。相反，尾扣带运动区（CMAc）和初级运动皮层（MI）中的细胞主要与运动或运动准备的执行有关。只有少量的CMAc细胞（3%）和MI细胞（1%）表现出与运动选择相关的活动。这些观察结果表明，CMAr在运动改变或运动选择的奖励评价的基础上发挥作用。另一方面，CMAc和MI都不是为了运动选择而处理奖励信息的皮质部位。