权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

NEURONAL ACTIVITY OF THE PREFRONTAL CORTEX IN RELATION TO TIME CODING.

与时间编码相关的前额叶皮层的神经元活动。

基本信息

批准号：
15500280
负责人：
SHIMA Keisetsu
金额：
$ 2.05万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500280/
关键词：
Time cording Neuronal activity Prefrontal cortex Monkey

项目摘要

The purpose of the present study was to examine how neuronal activity in the prefrontal cortex is involved in the time cording. For the first step to answer this question, we recorded neuronal activity in the prefrontal cortex during the performance of time period creation task.The monkey (Macaca fuscata) was trained to create the three different time periods (2, 4 or 8 sec). Each trial was started by pressing the hold key attached at the end of the forelimb brace. One to two seconds after the key press, one of the three lights was turned on for 2 sec, each of which indicating the minimum waiting period between the light onset to the hold key release. Yellow, red and green lights means 2, 4 and 8 sec of minimum waiting period, respectively. In addition, we also applied reversed rule, where the meaning of green and red lights was reversed. That is, green light indicated 8 sec of minimum waiting period and red light, 4 sec. This task was performed in a block manner. Each block consisted of 5 trials. Reversed rule was indicated by the lights flashed randomly for 2 sec, before the start of new block. The correct movement was rewarded with a drop of fruit juice (0.1 ml).In prefrontal cortex, about 70% of task-related neurons were active during the interval between the light onset and the initiation of movement Many prefrontal cortex neurons showed marked increased activity just after the light onset or relatively constant activity throughout the waiting period. A substantial number of prefrontal cortex neurons showed different activity between 2, 4, and 8 waiting periods. In some prefrontal cortex neurons, the magnitude of activity in 4 or 8 sec waiting period was different in the same waiting period in reversed rule. These observations indicate that the prefrontal cortex plays an important role in the execution of this task requiring to estimate and measure the different time periods.

本研究的目的是检查前额皮质中的神经元活动如何参与时间编码。为了回答这个问题，我们首先记录了执行时间段创建任务期间前额叶皮层的神经元活动。猴子 (Macaca fuscata) 接受训练来创建三个不同的时间段（2、4 或 8 秒）。每次试验都是通过按下前肢支架末端的保持键开始的。按键后一到两秒，三个灯之一亮起 2 秒，每个灯指示灯亮起到按住键释放之间的最短等待时间。黄灯、红灯和绿灯分别表示最短等待时间为 2 秒、4 秒和 8 秒。此外，我们还应用了颠倒规则，将绿灯和红灯的含义颠倒过来。也就是说，绿灯表示最短等待时间为 8 秒，红灯表示最短等待时间为 4 秒。该任务以块方式执行。每个区块包含 5 次试验。在新区块开始之前，灯光随机闪烁 2 秒，表示规则相反。正确的运动会得到一滴果汁（0.1毫升）的奖励。在前额叶皮层中，大约70%的任务相关神经元在光照开始和运动开始之间的间隔期间处于活跃状态。许多前额叶皮层神经元在光照开始后表现出明显的活动增加，或者在整个等待期间表现出相对稳定的活动。大量的前额皮质神经元在 2、4 和 8 个等待期之间表现出不同的活动。在某些前额叶皮层神经元中，4秒或8秒等待期内的活动强度与同一等待期内的活动强度不同，规律相反。这些观察结果表明，前额叶皮层在执行这项需要估计和测量不同时间段的任务中发挥着重要作用。