The role of vestibular cortex in control of eye movements

前庭皮层在控制眼球运动中的作用

• 批准号: 13680898
• 负责人: SUGIUCHI Yuriko
• 金额: $ 2.3万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680898/
• 关键词: vestibular cortex; vestibular nerve; superficial field potential; laminar field analysis; thalamocortical projection; 前頭眼野

The presence of the "vestibular cortex" has been very controversial for a long time. More than one areas have been reported to receive vestibular information so far, but the detailed properties of vestibular inputs to the cerebral cortex are yet to be determined. This study was performed to survey the whole extent of the cortical areas that receive vestibular inputs.1. The middle ear in the monkey is located deep from the neck surface, which makes surgical approach and electrode set-up very difficult. To place the stimulating electrodes on the vestibular nerves, a new trans-middle ear approach had to be developed.2. Using the above approach, silver ball electrodes were placed near the inner ear windows and the vestibular nerves were stimulated. Evoked potentials were recorded from the cortical surface of various cortical areas. Among them, areas 2v and 6pa showed 〓〓〓quivocal responses, and laminar field analysis was performed in these areas. As a result, it is concluded that the insula … More r cortex and area 6pa receive strong vestibular inputs.3. It has been reported from laminar field analysis of the cortical responses evoked by stimulation of the thalamus in the cat and monkey that there are two kinds of the thalamocortical responses; the superficial and deep thalamocortical response. Our previous study showed that superficial and deep thalamocortical responses reflect axon terminals of thalamocortical neurons in layeis I and II, and layers III-V, respectively. Based on these findings, the present laminar field analysis of the vestibular evoked field potentials recorded in the insular cortex and area 6pa revealed that the vestibular information is relayed to the cerebral cortex by both the superficial and the deep thalamocortical projection.4. It is essential to exclude the possibility that the evoked responses that we observed are the results of the current spread to other nerves located in the middle ear; the auditory nerve and the facial nerve. These possibilities were excluded by cutting each nerve in the internal auditory canal, 01 making lesion in the ascending MLF. The results showed that the above-mentioned vestibular evoked responses were of really vestibular nerve origin.5. These results were submitted to Journal of Neuroscience. Less

长期以来，前庭皮质的存在一直备受争议。到目前为止，已有不止一个区域被报道接收前庭信息，但前庭输入大脑皮层的详细特性尚未确定。这项研究是为了调查接受前庭输入的大脑皮层区域的整个范围。猴子的中耳位于颈部表面的深处，这使得手术入路和电极的设置非常困难。为了将刺激电极放置在前庭神经上，必须开发一种新的经中耳入路。采用上述方法，在内耳窗附近放置银球电极，刺激前庭神经。从不同皮质区域的皮质表面记录诱发电位。其中，2v区和6pa区表现为〓〓〓平淡反应，并对这些区域进行了层流场分析。因此，可以得出结论，半岛…更多的大脑皮层和6PA区接受强前庭输入。根据对猫和猴丘脑刺激引起的皮层反应的层流场分析，有两种类型的丘脑皮质反应：浅层丘脑皮质反应和深层丘脑皮质反应。我们以前的研究表明，丘脑皮质浅层和深层反应分别反映了第I层和第II层以及第III-V层的丘脑皮质神经元的轴突终末。基于这些发现，目前对记录在岛叶皮质和6PA区的前庭诱发电位的层流场分析表明，前庭信息通过丘脑皮质浅层和深层投射传递到大脑皮质。必须排除这样一种可能性，即我们观察到的诱发反应是电流传播到位于中耳的其他神经：听神经和面神经的结果。通过切断内耳道内的每一条神经，01在上行MLF处造成损伤，排除了这些可能性。结果表明，上述前庭诱发反应均为真正的前庭神经起源。这些结果发表在《神经科学杂志》上。较少

项目成果

Sugiuchi, Y et al.: "Functional synergies of neck muscles determined by branching patterns of single long descending motor tract axons"Progress in Brain Research. (in press).

Sugiuchi, Y 等人：“颈部肌肉的功能协同作用由单个长下降运动束轴突的分支模式决定”脑研究进展。