Construction of Diagnosis System of Blood Flow by CFD Based on Clinical MRI Data

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Recently, clinical image diagnosis instruments such as MRI (Magnetic Resonance Imaging, X-ray CT, Ultrasonic Doppler imaging etc. have developed and give us a large amount of high resolution image data. Especially, MRI data are obtained with negligible damage for human body and spread over many hospitals.The research results are categorized into the method for extracting blood structure from the MRI data, development of high accurate numerical scheme for blood flow simulation, and numerical results of blood flow simulation. By using B-spline interpolation, the blood structure of the brain for the blood flow CFD can be extracted with smooth curvatures from the MRA (magnetic resonance angiography). We have developed high accurate numerical scheme with local Hermite interpolation and the Cut-Cell method to describe blood vessel with complex geometry and AMR (Adaptive Mesh Refinement) method for adapting fine resolution around blood vessels on Cartesian grid. We carried out the numerical simulation for the interaction of the blood flow injected pulsatively with the elastic vessel. It is found that the pressure at the inner wall has lower peak than that of the rigid vessel case, and the velocity response of the outflow is delayed. We also studied micro-scale blood flow simulation with a particle model where non-Newtonian behaviors become important.We have obtained a lot of results for construction of the flood flow CFD analysis system for the individual clinical MRI data.