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Application of new zirconia/alumina composite ceramics to bearing surfaces of artificial joint prostheses

新型氧化锆/氧化铝复合陶瓷在人工关节假体承载面的应用

基本信息

批准号：
13680933
负责人：
TAMURA Jiro
金额：
$ 1.98万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13680933/
关键词：
zivconia alumina nanocom posite artifical joint biocom patibility wear resistance phase transformation 摩耗

项目摘要

We have investigated the biocompatibitity, phase stability and wear properties of Ce-TZP/Al_2O_3 nanocomposite1. Biocompatibility test: We implanted cylinder specimens of CeTZP/Al_2O_3 and Alumina into paraspinal muscles of male Wistar rats. The biocompatibility of CeTZP/Al_2O_3 was almost the same as that of Alumina. For both of ceramics, moderate soft tissue responses were noted at 1 week, and thereafter macrophages and lymphocytes decreased gradually. At 24 weeks, stable encapsulating membranes with some fibrocytes and almost no inflammatory cells were observed for both of ceramics. There were no significant differences of the membrane thickness between CeTZP/ Al_2O_3 nanocomposite and Alumina2. Aging test: Test specimens of CeTZP/AI2O3 and YTZP were kept under various aging conditions (rabbit tibiae, 62°C saline or autoclave). The surface of the specimens was examined after the aging treatments by thin-film X-ray diffraction, and the volumetric fraction of the monoclinic phase was determined. Although Y-TZP showed remarkable phase transformation under in vitro conditions, almost no change m the monoclinic rate was observed for Ce-TZP/Al_2O_3 under all conditions3. Wear test : In water lubrication ( contact pressure ;11.3MPa), the average wear rate of the pin was 2.12±0.37× 10^<-7>mm^3/Nm for Alumina and 0.55±0.04× 10^<-7>mm^3/Nm for Ce-TZP/Al_2O_3. In 30 vol% serum lubrication ( contact pressure ;50 Mpa), there were no remarkable differences in the wear rates of Ce-TZP/Al_2O_3 nonocomposite, Y-TZP and alumina specimens without aging (36 h autoclave). However, the wear rates of Y-TZP with aging were much higher than that of Ce-TZP/Al_2O_3 nonocomposite with agingThe present results suggest that this ceramic is very promising as a bearing component in artificial joint

研究了Ce-TZP/Al_2O_3纳米复合材料的生物相容性、相稳定性和磨损性能。生物相容性试验：将CeTZP/Al_2O_3和Al_2O_3圆柱体植入雄性Wistar大鼠椎旁肌内。CeTZP/Al_2O_3的生物相容性与Al_2O_3基本相同。对于两种陶瓷，在1周时观察到中度软组织反应，此后巨噬细胞和淋巴细胞逐渐减少。24周时，两种陶瓷均形成稳定的包封膜，包封膜内有纤维细胞，几乎无炎性细胞。CeTZP/ Al_2O_3纳米复合材料与Al_2O_3纳米复合材料的膜厚无显著差异。老化测试：将CeTZP/Al 2 O3和YTZP的测试样本保持在各种老化条件下（兔胫骨、62 ℃盐水或高压灭菌器）。通过薄膜X射线衍射对试样的表面进行了老化处理后的检查，并确定了单斜相的体积分数。虽然Y-TZP在体外条件下表现出显著的相变，但Ce-TZP/Al_2O_3在所有条件下的单斜率几乎没有变化3。磨损试验：在水润滑条件下（接触压力11.3MPa），Al_2O_3和Ce-TZP/Al_2O_3的销轴平均磨损率分别为2.12±0.37× 10 ~<-7>（^3）mm ~ 3/Nm和0.55±0.04× 10 ~<-7>（^3）mm ~ 3/Nm。在30vol%血清润滑（接触压力50 MPa）下，Ce-TZP/Al_2O_3纳米复合材料、Y-TZP和Al_2O_3三种材料的磨损率无显著差异。Y-TZP的磨损率随时效时间的延长而明显高于Ce-TZP/Al_2O_3纳米复合材料的磨损率。