Physiological Evaluation of Animal Room Environment for Rat and Rabbit using Telemetry system

利用遥测系统对大鼠和家兔动物房环境进行生理评价

基本信息

  • 批准号:
    13680914
  • 负责人:
  • 金额:
    $ 1.79万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2001
  • 资助国家:
    日本
  • 起止时间:
    2001 至 2003
  • 项目状态:
    已结题

项目摘要

In order to evaluate effects of housing conditions on rats and rabbits, we investigated variabilities in physiological parameters. Arterial blood pressure (BP), heart rate (HR) and body temperature (BT) were measured by telemetry in conscious unrestrained animals. Rats were housed in individual plastic cages floored with wood shavings. Rabbits were housed in individual FRP cages floored with stainless steel wire. The experimental room, a light-dark cycle (LD 12:12), was maintained under controlled temperature. The physiological signals were continuously recorded every 5 minutes by a telemetry system. These signals changed with a 24-hour cycle (circadian rhythm) in rats and rabbits. Nocturnal patterns, in which the values in the dark phase were higher than those in the light phase, were observed in rats and rabbits. However, BP and HR in rabbits were lower than those in rats. All animals indicated the rhythms of physiological signals in wide range of room temperature (17-30 degrees centigrade). Male cotton rats showed clear peaks of BT after the light off and on. The difference of dark-light temperature in rabbits was less than in rats. The results suggest that temperature above 28 or below 18 degrees centigrade might produce physiological effects to rats and rabbits. A telemetry system may be useful to evaluate effects of housing conditions on rats and rabbits. Rats and rabbits may adapt to extremes by behavioral, physiologic, and morphologic mechanisms, but such adaptation takes time and might alter experimental outcomes or otherwise affect performance. Thus ventilation in animal room is very important to remove thermal loads caused by animal respiration, lights, and equipment.
为了评估居住条件对大鼠和家兔的影响,我们研究了生理参数的变化。采用遥测法测定清醒无约束动物的动脉血压(BP)、心率(HR)和体温(BT)。老鼠被关在单独的塑料笼子里,地板上铺着木屑。兔子被关在单独的玻璃钢笼中,笼上铺着不锈钢丝。实验室内,一个光-暗循环(LD 12:12),保持在受控温度下。遥测系统每5分钟连续记录一次生理信号。在大鼠和家兔中,这些信号以24小时为周期(昼夜节律)变化。在大鼠和家兔的夜间模式中,在黑暗阶段的值高于光明阶段的值。但家兔血压和心率均低于大鼠。所有动物在室温(17 ~ 30℃)的大范围内均表现出生理信号的节律性。雄棉大鼠在关灯和开灯后BT呈明显的峰值。家兔的暗光温度差异小于大鼠。结果表明,高于28摄氏度或低于18摄氏度的温度可能对大鼠和家兔产生生理影响。遥测系统可能有助于评估住房条件对大鼠和兔子的影响。大鼠和家兔可能通过行为、生理和形态机制来适应极端情况,但这种适应需要时间,并可能改变实验结果或以其他方式影响其表现。因此,动物室内的通风对于消除动物呼吸、灯光和设备引起的热负荷非常重要。

项目成果

期刊论文数量(28)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
テレメトリー法による生理指標からみたウサギ飼育室の適正な温度について
遥测法从生理指标角度探讨兔饲养室适宜温度
Inventive improvement for animal cages and equipment.
对动物笼舍和设备进行创造性改进。
Circadian rhythm of blood pressure and heart rate in SHR and SD rats.
SHR 和 SD 大鼠血压和心率的昼夜节律。
Evaluation of rearing activity in cotton rat.
棉鼠饲养活动评价。
ラットの授乳期間中における血圧と心拍数の日内変
大鼠哺乳期间血压和心率的日变化
{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

KATAHIRA Kiyoaki其他文献

KATAHIRA Kiyoaki的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('KATAHIRA Kiyoaki', 18)}}的其他基金

Evidence of humane endpoints for laboratory animals using bio-telemetry method
使用生物遥测方法对实验动物进行人道终点的证据
  • 批准号:
    20500375
  • 财政年份:
    2008
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Near-room Temperature Solid-state Hydrogen Storage
近室温固态储氢
  • 批准号:
    EP/Y007778/1
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Research Grant
Electric and optical manipulation of 2D excitons for room temperature polariton blockade and valley qubits
用于室温极化子封锁和谷量子位的二维激子的电和光操纵
  • 批准号:
    EP/Y021789/1
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Research Grant
The development of new instruments based on miniaturised room temperature MASERs: MASER in a Shoebox
基于小型化室温 MASER 的新仪器的开发:鞋盒中的 MASER
  • 批准号:
    EP/Y00471X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Research Grant
Room Temperature High Energy Density Sodium-Sulfur Batteries
室温高能量密度钠硫电池
  • 批准号:
    DP240101548
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Discovery Projects
CAREER: Towards room-temperature quantum simulators enabled by halide perovskites
职业:迈向由卤化物钙钛矿实现的室温量子模拟器
  • 批准号:
    2414131
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Continuing Grant
Mid-infrared quantum dots for room temperature photodetectors and emitters
用于室温光电探测器和发射器的中红外量子点
  • 批准号:
    DP240101309
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Discovery Projects
Electric and optical manipulation of 2D excitons for room temperature polariton blockade and valley qubits
用于室温极化子封锁和谷量子位的二维激子的电和光操纵
  • 批准号:
    EP/Y021339/1
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Research Grant
Room-temperature flexible manipulation of the quantum-metric structure in topological chiral antiferromagnets
拓扑手性反铁磁体中量子度量结构的室温灵活操控
  • 批准号:
    24K16999
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Developing Room-Temperature Liquid Metal Batteries for Safe Energy Storage
开发用于安全储能的室温液态金属电池
  • 批准号:
    DE240100159
  • 财政年份:
    2024
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Discovery Early Career Researcher Award
Exploring the differences in the structural characterisation of inhibitor binding between cryo- and room-temperature using multicrystal X-ray crystall
使用多晶 X 射线晶体探索低温和室温下抑制剂结合的结构特征差异
  • 批准号:
    2897123
  • 财政年份:
    2023
  • 资助金额:
    $ 1.79万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了