Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression
Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression
批准号:
DP0345376
负责人:
Prof Matthew Wilce
金额:
$23.94万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2003
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2003-03-18 至 2006-12-31
中文摘要
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英文摘要
RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The current study will investigate the structural and biophysical properties of a recently discovered HuR/PCBP/mRNA complex implicated in the regulation of androgen receptor expression. This information has the potential to assist in the development of drugs to reduce AR expression in prostate cancer.
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Protein-RNA interactions in antiviral cellular defence and gene regulation
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批准号:nhmrc : 1079611
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项目类别:Research Fellowships
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资助金额:$47.04万
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财政年份:2015
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负责人:Prof Matthew Wilce
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依托单位:
Protein-RNA interactions in antiviral cellular defence and gene regulation
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批准号:nhmrc : GNT1079611
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项目类别:Research Fellowships
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资助金额:$67.58万
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财政年份:2015
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负责人:Prof Matthew Wilce
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依托单位:
Specificity and architecture of protein-mRNA interactions regulating gene expression
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批准号:DP110102056
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项目类别:Discovery Projects
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资助金额:$24.63万
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财政年份:2011
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负责人:Prof Matthew Wilce
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依托单位:
A biomolecular small angle X-ray scattering facility
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批准号:LE100100207
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$33.34万
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财政年份:2010
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负责人:Prof Matthew Wilce
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依托单位:
Protein-mRNA interactions and their role in post-transcriptional regulation
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批准号:DP0879279
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项目类别:Discovery Projects
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资助金额:$49.94万
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财政年份:2008
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负责人:Prof Matthew Wilce
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依托单位:
Research Fellowship - Grant ID:436631
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批准号:nhmrc : 436631
-
项目类别:NHMRC Research Fellowships
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资助金额:$49.96万
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财政年份:2007
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负责人:Prof Matthew Wilce
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依托单位:
REGULATION OF ANDROGEN RECEPTOR and erbB-2 GENE EXPRESSION IN PROSTATE CANCER: ROLE OF THE HU PROTEINS
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批准号:nhmrc : 353575
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项目类别:NHMRC Project Grants
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资助金额:$31.41万
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财政年份:2005
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负责人:Prof Matthew Wilce
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依托单位:
Molecular machines: regulation of the catalysis and rotation of the enzyme ATP synthase
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资助金额:$21.66万
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负责人:Prof Matthew Wilce
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依托单位:
Protein Over-Expression/Purification and Macromolecular Structure Determination by X-Ray Diffraction
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批准号:LE0346892
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$47.03万
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财政年份:2003
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负责人:Prof Matthew Wilce
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依托单位:
Crystal structures of ATPase components, calponin and type 2C serine/threonine phosphatase
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批准号:nhmrc : 980089
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项目类别:NHMRC Project Grants
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资助金额:$13.42万
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财政年份:1998
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负责人:Prof Matthew Wilce
-
依托单位:
国内基金
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