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Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression

Structure and dynamics of a multiprotein-mRNA complex involved in the regulation of gene expression
参与基因表达调控的多蛋白-mRNA复合物的结构和动力学
批准号:
DP0345376
负责人:
Prof Matthew Wilce
金额:
$23.94万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2003
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2003-03-18 至 2006-12-31

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中文摘要
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英文摘要
RNA/protein interactions are now recognised as a major control point in the regulation of gene-expression. Proteins such as HuR and the poly(C)-binding proteins (PCBPs) act to stabilise and transport specific messenger (m)RNAs, and thus determine their translation levels. In contrast to such an important function, very little is known about these protein/mRNA interactions at an atomic level. The current study will investigate the structural and biophysical properties of a recently discovered HuR/PCBP/mRNA complex implicated in the regulation of androgen receptor expression. This information has the potential to assist in the development of drugs to reduce AR expression in prostate cancer.
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Protein-RNA interactions in antiviral cellular defence and gene regulation
  • 批准号:
    nhmrc : 1079611
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $47.04万
  • 财政年份:
    2015
  • 负责人:
    Prof Matthew Wilce
  • 依托单位:
Protein-RNA interactions in antiviral cellular defence and gene regulation
  • 批准号:
    nhmrc : GNT1079611
  • 项目类别:
    Research Fellowships
  • 资助金额:
    $67.58万
  • 财政年份:
    2015
  • 负责人:
    Prof Matthew Wilce
  • 依托单位:
Specificity and architecture of protein-mRNA interactions regulating gene expression
  • 批准号:
    DP110102056
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $24.63万
  • 财政年份:
    2011
  • 负责人:
    Prof Matthew Wilce
  • 依托单位:
A biomolecular small angle X-ray scattering facility
  • 批准号:
    LE100100207
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $33.34万
  • 财政年份:
    2010
  • 负责人:
    Prof Matthew Wilce
  • 依托单位:
国内基金
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  • 批准号:
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  • 资助金额:
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  • 批准年份:
    2023
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用于对微管动态结构实时定量分析的荧光探针
  • 批准号:
    32070708
  • 项目类别:
    面上项目
  • 资助金额:
    58.0万元
  • 批准年份:
    2020
  • 负责人:
    谢松波
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钱江潮汐影响下越江盾构开挖面动态泥膜形成机理及压力控制技术研究
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    LY21E080004
  • 项目类别:
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  • 资助金额:
    --
  • 批准年份:
    2020
  • 负责人:
    尹鑫晟
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