Evaluation of Degradation Characteristics of Ni-Ti Super-Elastic Alloy in Quasi-Human Body Environment and Improvement of its Bio-Compatibility by Surface Modification

镍钛超弹性合金在准人体环境中的降解特性评价及表面改性提高其生物相容性

基本信息

批准号：
14205022
负责人：
KIMURA Yuji
金额：
$ 25.38万
依托单位：
Kogakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

In recent years, the demand for a biomedical material is increasing with the formation of the aged society with a low birth rate, together with the lowering in joint disease patient's age. Biomaterials mean the materials specially designed for the repair, reconstruction, and replacement of diseased or damaged part of human-body. Bio materials must have the reliability to hold their functions during expected time in the human body and also they have to show bio-compatibility to the living body. Nickel-titanium shape memory alloy(Ni-Ti alloy) has unique mechanical properties such as shape memory effect and super elasticity along with good wear and corrosion resistances. For this reason Ni-Ti alloy is expected to use as implants material in the biomedical field. However, the degradation characteristics in living body environment and the biocompatibility of Ni-Ti alloy is not fully examined. The purpose of this research to evaluate in vitro corrosion and wear-corrosion resistances, cytocom … More patibility and the biological response of bio materials, especially to evaluate inflammatory response by in vivo animal implantation assays and improvement of corrosion resistance for Ni-Ti alloy by various surface modifications.Therefore, authors have been conducted various researches from the following view points.(1)Evaluations of degradation characteristics of bio materials in quasi-human body environment and the biological response of bio materials(2)Improvement of degradation characteristics of Ni-Ti super-elastic alloy in living body environment by various surface modifications(3)Establishment of materials systems with better bio-compatibilityResults obtained are summarized through categorizing into following items.・Evaluation of Corrosion Degradation Behavior and Bio-compatibility and of Ni-Ti Shape Memory Alloy・Evaluation of Compatibility of Nickel-Titanium Shape Memory Alloy with Femur Surrounding Tissue・Corrosion and Wear Corrosion Characteristics of Various Substitutive-Materials for Living Body in Quasi-Human Body Environment・Effects of Additional Elements on Erosion and Wear Characteristics in Ni-Ti Shape Memory Alloy・Evaluation of Corrosion Resistance of Biomaterial Titanium Alloy and Formation of Biocompatible Calcium Phosphate Thin Film Using Electrochemical Method・Contact Corrosion Fatigue of Bio-Ceramics in Quasi-human Body Environment Less

近年来，随着老年社会的形成，对生物医学材料的需求正在增加，而较低的出生率以及关节疾病患者年龄的降低。生物材料是指专门为修复，重建和替代人体或损坏部分的材料。生物材料必须具有可靠性，以在人体预期的时间内保持其功能，并且必须表现出对生物的生物兼容。镍氨基烷的形状记忆合金（Ni-Ti合金）具有独特的机械性能，例如形状记忆效应和超级弹性以及良好的磨损和耐腐蚀性。因此，预计Ni-Ti合金将用作生物医学领域中的材料。然而，尚未完全检查生命体环境中的降解特性和Ni-Ti合金的生物相容性。这项研究的目的是评估体外腐蚀和耐磨性耐药性，细胞感受…更可贴纤维和生物材料的生物材料反应，尤其是评估体内动物植入测定法和通过各种表面修饰的Ni-TI耐腐蚀性的耐腐蚀性的炎症反应。生物材料在准人体环境中的特征和生物材料的生物材料反应（2）通过各种表面修改来改善Ni-Ti超弹性合金在生命体内环境中的降解特征（3）通过更好地进行生物兼容性的材料系统，通过对以下物品进行分类和评估。 Ni-Ti Shape Memory Alloy・Evaluation of Compatibility of Nickel-Titanium Shape Memory Alloy with Femur Surrounding Tissue・Corrosion and Wear Corrosion Characteristics of Various Substitutive-Materials for Living Body in Quasi-Human Body Environment・Effects of Additional Elements on Erosion and Wear Characteristics in Ni-Ti Shape Memory Alloy・Evaluation of Corrosion Resistance of Biomaterial Titanium Alloy and Formation of使用电化学方法的磷酸钙薄膜生物相容性钙・在准人体环境中生物陶瓷的接触腐蚀疲劳较少