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Evaluation of Degradation Characteristics of Ni-Ti Super-Elastic Alloy in Quasi-Human Body Environment and Improvement of its Bio-Compatibility by Surface Modification

镍钛超弹性合金在准人体环境中的降解特性评价及表面改性提高其生物相容性

基本信息

批准号：
14205022
负责人：
KIMURA Yuji
金额：
$ 25.38万
依托单位：
Kogakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

In recent years, the demand for a biomedical material is increasing with the formation of the aged society with a low birth rate, together with the lowering in joint disease patient's age. Biomaterials mean the materials specially designed for the repair, reconstruction, and replacement of diseased or damaged part of human-body. Bio materials must have the reliability to hold their functions during expected time in the human body and also they have to show bio-compatibility to the living body. Nickel-titanium shape memory alloy(Ni-Ti alloy) has unique mechanical properties such as shape memory effect and super elasticity along with good wear and corrosion resistances. For this reason Ni-Ti alloy is expected to use as implants material in the biomedical field. However, the degradation characteristics in living body environment and the biocompatibility of Ni-Ti alloy is not fully examined. The purpose of this research to evaluate in vitro corrosion and wear-corrosion resistances, cytocom … More patibility and the biological response of bio materials, especially to evaluate inflammatory response by in vivo animal implantation assays and improvement of corrosion resistance for Ni-Ti alloy by various surface modifications.Therefore, authors have been conducted various researches from the following view points.(1)Evaluations of degradation characteristics of bio materials in quasi-human body environment and the biological response of bio materials(2)Improvement of degradation characteristics of Ni-Ti super-elastic alloy in living body environment by various surface modifications(3)Establishment of materials systems with better bio-compatibilityResults obtained are summarized through categorizing into following items.・Evaluation of Corrosion Degradation Behavior and Bio-compatibility and of Ni-Ti Shape Memory Alloy・Evaluation of Compatibility of Nickel-Titanium Shape Memory Alloy with Femur Surrounding Tissue・Corrosion and Wear Corrosion Characteristics of Various Substitutive-Materials for Living Body in Quasi-Human Body Environment・Effects of Additional Elements on Erosion and Wear Characteristics in Ni-Ti Shape Memory Alloy・Evaluation of Corrosion Resistance of Biomaterial Titanium Alloy and Formation of Biocompatible Calcium Phosphate Thin Film Using Electrochemical Method・Contact Corrosion Fatigue of Bio-Ceramics in Quasi-human Body Environment Less

近年来，随着低生育率老龄化社会的形成，以及关节病患者低龄化，对生物医用材料的需求不断增加。生物材料是指专门用于修复、重建和替换人体患病或受损部位的材料。生物材料必须具有在人体内预期时间内保持其功能的可靠性，并且还必须表现出与活体的生物相容性。镍钛形状记忆合金（Ni-Ti合金）具有形状记忆效应、超弹性等独特的机械性能，同时具有良好的耐磨性和耐腐蚀性。因此镍钛合金有望在生物医学领域用作植入材料。然而，Ni-Ti合金在活体环境中的降解特性和生物相容性尚未得到充分研究。本研究的目的是评估生物材料的体外腐蚀和磨损腐蚀、细胞相容性和生物反应，特别是通过体内动物植入实验评估炎症反应以及通过各种表面修饰提高镍钛合金的耐腐蚀性。因此，作者从以下角度进行了各种研究。（1）生物降解特性的评估准人体环境中的材料和生物材料的生物响应(2)通过各种表面改性改善镍钛超弹性合金在活体环境中的降解特性(3)建立具有更好生物相容性的材料系统获得的结果总结为以下几项。・腐蚀降解行为和生物相容性以及镍钛形状记忆的评估合金・镍钛形状记忆合金与股骨周围组织的相容性评价・准人体环境中各种生命体替代材料的腐蚀和磨损腐蚀特性・添加元素对镍钛形状记忆合金冲蚀磨损特性的影响・生物材料钛合金的耐腐蚀性评价及生物相容性钙的形成电化学法磷酸盐薄膜・准人体环境中生物陶瓷的接触腐蚀疲劳 Less