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Evaluation of Degradation Characteristics of Ni-Ti Super-Elastic Alloy in Quasi-Human Body Environment and Improvement of its Bio-Compatibility by Surface Modification

镍钛超弹性合金在准人体环境中的降解特性评价及表面改性提高其生物相容性

基本信息

批准号：
14205022
负责人：
KIMURA Yuji
金额：
$ 25.38万
依托单位：
Kogakuin University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

In recent years, the demand for a biomedical material is increasing with the formation of the aged society with a low birth rate, together with the lowering in joint disease patient's age. Biomaterials mean the materials specially designed for the repair, reconstruction, and replacement of diseased or damaged part of human-body. Bio materials must have the reliability to hold their functions during expected time in the human body and also they have to show bio-compatibility to the living body. Nickel-titanium shape memory alloy(Ni-Ti alloy) has unique mechanical properties such as shape memory effect and super elasticity along with good wear and corrosion resistances. For this reason Ni-Ti alloy is expected to use as implants material in the biomedical field. However, the degradation characteristics in living body environment and the biocompatibility of Ni-Ti alloy is not fully examined. The purpose of this research to evaluate in vitro corrosion and wear-corrosion resistances, cytocom … More patibility and the biological response of bio materials, especially to evaluate inflammatory response by in vivo animal implantation assays and improvement of corrosion resistance for Ni-Ti alloy by various surface modifications.Therefore, authors have been conducted various researches from the following view points.(1)Evaluations of degradation characteristics of bio materials in quasi-human body environment and the biological response of bio materials(2)Improvement of degradation characteristics of Ni-Ti super-elastic alloy in living body environment by various surface modifications(3)Establishment of materials systems with better bio-compatibilityResults obtained are summarized through categorizing into following items.・Evaluation of Corrosion Degradation Behavior and Bio-compatibility and of Ni-Ti Shape Memory Alloy・Evaluation of Compatibility of Nickel-Titanium Shape Memory Alloy with Femur Surrounding Tissue・Corrosion and Wear Corrosion Characteristics of Various Substitutive-Materials for Living Body in Quasi-Human Body Environment・Effects of Additional Elements on Erosion and Wear Characteristics in Ni-Ti Shape Memory Alloy・Evaluation of Corrosion Resistance of Biomaterial Titanium Alloy and Formation of Biocompatible Calcium Phosphate Thin Film Using Electrochemical Method・Contact Corrosion Fatigue of Bio-Ceramics in Quasi-human Body Environment Less

近年来，随着低出生率的老龄化社会的形成，以及关节疾病患者年龄的降低，对生物医学材料的需求正在增加。生物材料是指为修复、重建和替代人体病变或损伤部位而专门设计的材料。生物材料必须具有在人体内预期时间内保持其功能的可靠性，并且必须显示出与活体的生物相容性。镍钛形状记忆合金（Ni-Ti合金）具有独特的力学性能，如形状记忆效应和超弹性沿着，同时具有良好的耐磨性和耐腐蚀性。因此，镍钛合金有望作为生物医学领域的植入材料。然而，镍钛合金在生物体环境中的降解特性和生物相容性尚未得到充分研究。本研究的目的是评估体外耐腐蚀性和耐磨损腐蚀性，cytocom ...更多信息生物材料的相容性和生物学反应，特别是通过体内动物植入试验评估炎症反应，以及通过各种表面改性提高Ni-Ti合金的耐腐蚀性，因此，作者从以下角度进行了各种研究。（1）生物材料在准人体环境中的降解特性及其生物学响应的评价（2）通过各种表面改性改善Ni-Ti超弹性合金在活体环境中的降解特性（3）建立具有较好生物相容性的材料体系Ni-Ti形状记忆合金的腐蚀降解行为和生物相容性评价·Ni-Ti形状记忆合金与股骨周围组织的相容性评价·各种生物体替代材料在准人体环境中的腐蚀磨损特性·添加元素对Ni-Ti形状记忆合金腐蚀磨损特性的影响·生物材料钛合金耐蚀性的电化学评价及生物相容性磷酸钙薄膜的制备·生物陶瓷在准人体环境中的接触腐蚀疲劳