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Basic Study on Surgical System for Non-Invasive Osteotomy using High Intensity Focused Ultrasound

高强度聚焦超声无创截骨手术系统的基础研究

基本信息

批准号：
14208102
负责人：
DOHI Takeyoshi
金额：
$ 30.45万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

[Introduction]An experimental system for non-invasive ostetomy using high intensity focused ultrasound(HIFU) was developed and assessed in this study. [Materials and methods](1)HIFU was exposed from a transducer with a PZT element to the porcine bone fixed in a pool filled with degassed water. Conditions of wave form, frequency and intensity of the input signal were varied. (2)The energy exposed to the focal point was measured experimentally and compared with the one calculated by the developed simulation software using Finite Difference Time Domain Method (3)Voltage of square wave applied to a PZT element was composed of odd multiple resonant frequency wave currents to increase acoustic pressure. HIFU was exposed from 5 transducers while matching at the same focal point. [Results and discussions](1)The energy calculated at the focal point matched the one measured experimentally at a rate of approximately 90 percent. The simulation showed that a PZT element with larger curvature contributed to higher acoustic pressure as long as the size of the transducer opening was constant. (2)The measured acoustic pressure at the focal point was as 3 times in case of applied voltage of square wave as in case of sine wave. A circular cutting mark of 1 mm in diameter and 0.5 mm in depth was observed on the bone after the exposure of HIFU from 2 transducers. The measured acoustic pressure was as 1.65 times in case that HIFU exposed from 5 transducers each of which was applied with 30 W electricity as in case of only one transducer applied with 30 W electricity. The acoustic pressure was considered to be increased by improvement of impedance matching in the amplifier of the input signal. [Conclusion]An experimental system using HIFU suggested possible contribution of HIFU to the effective bone cutting.

【导读】本研究开发并评估了一种利用高强度聚焦超声（HIFU）进行无创截骨的实验系统。【材料与方法】(1)将HIFU从带有PZT元件的换能器暴露在固定在充满脱气水的池中的猪骨上。输入信号的波形、频率和强度条件是不同的。(2)采用时域有限差分法实验测量了暴露在焦点上的能量，并与开发的仿真软件计算的能量进行了比较。(3)PZT元件的方波电压由奇数倍谐振频率波电流组成，以增加声压。在同一焦点匹配时，从5个换能器暴露HIFU。[结果与讨论](1)在焦点处计算的能量与实验测量的能量匹配率约为90%。仿真结果表明，在换能器开口一定的情况下，曲率较大的压电陶瓷元件可以获得较高的声压。(2)施加方波电压时，测点处的声压是施加正弦波电压时的3倍。2个换能器暴露HIFU后，在骨上观察到直径为1mm，深度为0.5 mm的圆形切割痕迹。当5个换能器分别施加30w的电时，HIFU所测得的声压是仅一个换能器施加30w电时的1.65倍。通过改进输入信号放大器的阻抗匹配，可以提高声压。[结论]一个使用HIFU的实验系统提示HIFU可能对有效的骨切割有贡献。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Morikawa S, Inubushi T, Kurumi Y, Naka S, Sato K, Tani T, Haque HA, Tokuda J, Hata N: "New Assistive Devices for MR-guided Microwave Thermocoagulation of Liver Tumors"Academic Radiology. 10. 180-188 (2003)

Morikawa S、Inubushi T、Kurumi Y、Naka S、Sato K、Tani T、Haque HA、Tokuda J、Hata N：“磁共振引导肝脏肿瘤微波热凝的新型辅助装置”学术放射学。

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大橋晃太, 波多伸彦, 松村有子, 緒方徹, 佐久間一郎, 矢作直樹, 土肥健純: "骨穿孔小型軟性ドリルを用いた骨髄移植用造血幹細胞採取マニピュレータの開発"日本コンピュータ外科学会誌. (印刷中). (2003)

Kota Ohashi、Nobuhiko Hata、Yuko Matsumura、Toru Ogata、Ichiro Sakuma、Naoki Yahagi、Kenzumi Doi：“开发使用小型骨钻小软钻进行骨髓移植的造血干细胞采集机械手”日本计算机学会杂志手术（正在出版）（2003）。

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Hirose M, Bharatha A, Hata N, Zou KH, Warfield SK, Cormack RA, D'Amico A, Kikinis R, Jolesz FA, Tempany CMC: "Quantative MR Imaging Assesment of Prostate Gland Deformation before and during MR Imaging-guided Brachytherapy"Academic Radiology. 9(8). 906-912

Hirose M、Bharatha A、Hata N、Zou KH、Warfield SK、Cormack RA、DAmico A、Kikinis R、Jolesz FA、Tempany CMC：“MR 成像引导近距离放射治疗之前和期间前列腺变形的定量 MR 成像评估”

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A study on improving the cutting efficiency of extracorporeal shock wave osteotomy

提高体外冲击波截骨术切割效率的研究

DOI：
发表时间：
2004
期刊：
Journal of Japan Society of Computer Aided Surgery 6(3)
影响因子：
0
作者：
Yuji Ukai;Kiyoshi Matsumiya;Nobuhiko Hata;Takashi Azuma;Shinichiro Umemura;Takeyoshi Dohi
通讯作者：
Takeyoshi Dohi

複数トランスデューサを用いた体外衝撃波骨切除術

使用多个换能器的体外冲击波截骨术