SYNTHESIS OF FERRIMAGNETIC CERAMIC MICROSPHERES FOR LOCAL HYPERTHERMIA OF DEEP-SEATED CANCER

用于深部癌症局部热疗的亚铁磁陶瓷微球的合成

• 批准号: 14550800
• 负责人: KAWASHITA Masakazu
• 金额: $ 2.05万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14550800/
• 关键词: MICROSPHERE; FERRIMAGNETISM; MAGNETITE; DEEP-SEATED CANCER; HYPERTHERMIA; HYSTERESIS LOSS; PRECIPITATION; HIGH-FREQUENCY INDUCTION THERMAL PLASMA; 温熱治療; 磁気ヒステリシス損; 高周波誘導熱プラズマ溶融法; β-FeOOH; 水溶液折出法

Pure Fe_3O_4 microspheres 20-30 μm in diameter can be prepared by melting powders in high-frequency induction thermal plasma and subsequent heat treatment. The heat-treated microspheres show the heat generation, 10 W・g^<-1>, under 300 0e and 100 kHz. The microspheres 20-30 μm in diameter containing small crystals of Fe_3O_4 50 nm in size can be prepared by a precipitation from solution and subsequent heat treatment. The heat-treated microspheres show the heat generation, 41 W・g^<-1>, under 300 0e and 100 kHz. The microspheres prepared by a precipitation from solution and subsequently subjected to heat treatment can be a promising candidate of thermoseeds for hyperthermia of cancer, since they can show a n excellent heat generating ability.

用高频感应热等离子体熔融粉末，经热处理，可制得直径为20-30 μm的纯Fe_3O_4微球。在300 0 e和100 kHz下，热处理后的微球的产热为10 W·g^<-1>。用溶液沉淀法和热处理法可制得粒径为20-30 μm的Fe_3O_4微球。在300 0 e和100 kHz下，热处理后的微球的产热为41 W·g^<-1>。通过溶液沉淀法制备的微球经热处理后具有良好的产热能力，有望成为肿瘤热疗热种子的候选材料。

项目成果

M.KAWASHITA: "RESEARCH ON CERAMIC MICROSPHERES FOR MINIMALLY INVASIVE AND LOCAL TREATMENT OF CANCER"BIOMATERIAL-SEITAIZAIRYO. 22. 36-42 (2003)

M.KAWASHITA：“用于癌症微创和局部治疗的陶瓷微球的研究”生物材料-SeitaiZairyo。

川下 将一: "深部がん局所温熱治療のための強磁性微小球"NEW GLASS. 18. 27-31 (2003)

Shoichi Kawashita：“用于深部癌症局部热处理的铁磁微球”NEW GLASS 18. 27-31 (2003)。

M.Kawashita: "Preparation of magnetite microspheres for hypertermia of cancer"KEY ENGINEERING MATERIALS. 218-220. 645-658 (2002)

M.Kawashita：“用于癌症高温的磁铁矿微球的制备”关键工程材料。

M.Kawashita: "Ceramic microspheres for in situ radiotherapy of cancer"Mater.Sci.and Engin.C. C22. 3-8 (2002)

M.Kawashita：“用于癌症原位放射治疗的陶瓷微球”Mater.Sci.and Engin.C。

M.KAWASHITA: "FERRIMAGNETIC MICROSPHERES FOR LOCAL HYPERTHERMIA OF DEEP-SEATED CANCER"NEW GLASS. 18. 27-31 (2003)

M.KAWASHITA：“用于深部癌症局部热疗的亚铁磁微球”新玻璃。