The association with bFGF, HGF and protection of neural system and cardio-vascular disease.

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The aim of this study was to investigate bFGF (basic Fibroblast Growth Factor) and HGF (Hepatocyte growth factor) with relation to risk of stroke and acute myocardial infarction in the community population and to examine whether such factors were useful for the prediction for cardio-vascular disease risk, independent of ordinary cardio-vascular risk factors.At first, we constructed a population-based cohort study of 4,475 subjects (1,541men and 2,934 women). A base-line survey was conducted between April 1996 and December 1998. Cardio-vascular events were included in the analysis if the occurred after date of base-line survey and before December 31, 2004.In this cohort study, we calculated nested case-control study and sampled cases and controls by 1:3. At statistical analyses, the relative risk was calculated after adjusting for smoking habits and other ordinal cardio-vascular risk factors using the multiple regression analysis.After 30,885 person-year follow-up, 96 stroke cases and 12 acute myocardial infarction cases were documented. The bFGF and HGF was negatively associated with risk of stroke and cardio-vascular diseases. And HGF was negatively associated significantly after adjusted other risk factors.In conclusion, our study indicated that bFGF and HGF were independent risk factors for such diseases. And we found these factors had a potential of protection for tissue-ischemia in vivo.