The association with bFGF, HGF and protection of neural system and cardio-vascular disease.

与bFGF、HGF与神经系统和心血管疾病保护的关系。

• 批准号: 15390203
• 负责人: KONISHI Masamitsu
• 金额: $ 9.6万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390203/
• 关键词: Stroke; Cardio-vascular disease; Hypertension; bFGF; HGF; Brain; Neural system; 脳神経; 頸動脈超音波検査; 心筋梗塞

The aim of this study was to investigate bFGF (basic Fibroblast Growth Factor) and HGF (Hepatocyte growth factor) with relation to risk of stroke and acute myocardial infarction in the community population and to examine whether such factors were useful for the prediction for cardio-vascular disease risk, independent of ordinary cardio-vascular risk factors.At first, we constructed a population-based cohort study of 4,475 subjects (1,541men and 2,934 women). A base-line survey was conducted between April 1996 and December 1998. Cardio-vascular events were included in the analysis if the occurred after date of base-line survey and before December 31, 2004.In this cohort study, we calculated nested case-control study and sampled cases and controls by 1:3. At statistical analyses, the relative risk was calculated after adjusting for smoking habits and other ordinal cardio-vascular risk factors using the multiple regression analysis.After 30,885 person-year follow-up, 96 stroke cases and 12 acute myocardial infarction cases were documented. The bFGF and HGF was negatively associated with risk of stroke and cardio-vascular diseases. And HGF was negatively associated significantly after adjusted other risk factors.In conclusion, our study indicated that bFGF and HGF were independent risk factors for such diseases. And we found these factors had a potential of protection for tissue-ischemia in vivo.

本研究的目的是在社区人群中研究碱性成纤维细胞生长因子和肝细胞生长因子与中风和急性心肌梗死风险的关系，并检验这些因素是否有助于独立于普通心血管危险因素预测心血管疾病风险。首先，我们建立了一项基于人群的队列研究，研究对象为4475名受试者(男性1541名，女性2934名)。1996年4月至1998年12月期间进行了基线调查。发生在基线调查日期之后和2004年12月31日之前的心血管事件纳入分析。本次队列研究采用嵌套病例对照研究，以1：3抽样病例和对照。在统计分析中，在调整吸烟习惯和其他心血管危险因素后，采用多元回归分析计算相对危险度。经过30885人年的随访，96例中风和12例急性心肌梗死。碱性成纤维细胞生长因子和肝细胞生长因子与卒中和心血管疾病的风险呈负相关。在调整了其他危险因素后，HGF呈显著的负相关。结论：bFGF和HGF是此类疾病的独立危险因素。我们发现这些因子对体内组织缺血有潜在的保护作用。