Analysis for the coagulation, atherosclerosis and cerebro-vascular disease association with Inflammation and Immune-reaction

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In Japan, recently, the feature of the cerebro vascular disease (CVD) has been changed, largely due to the measures of preventive CVD and the changes from Japanese traditional lifestyles to westernized lifestyles, including diet and working. At present, however, the morbidity and mortality of brain stroke were more frequent than North Americans and Europeans. The aim of this study was to investigate new methods of the prevention of the cardiovascular disease.In this study, the activation of IL-6 receptor was association with the plaque indexes of the carotid ultrasonography. And increase of the share rate was association with plaques. This result shows that mechanical function of blood flow irritates the atherosclerotic changes through of the immuno-inflammation responses. By the case-control study, there was significantly relation between indexes of carotid ultrasonography and brain infarction. But there were some limits about this result. The association with the lacunar infarction was slightly below that of the large artery infarction. Moreover, among Japanese, the measurement of the carotid ultrasonography simultaneously with the IL-6 should be emphasized for screening method of the brain infarction.The other analysis of this study, the exercise was negative association with atherosclerotic changes of the carotid artery. There for, the preserving exercise was the measure of preventive atherosclerosis and CVD.