Analysis for the coagulation, atherosclerosis and cerebro-vascular disease association with Inflammation and Immune-reaction

凝血、动脉粥样硬化、脑血管疾病与炎症、免疫反应的关系分析

• 批准号: 13670368
• 负责人: KONISHI Masamitsu
• 金额: $ 2.62万
• 依托单位: Ehime University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670368/
• 关键词: Carotid sonography; Cerebro-vascular disease; exercise; share rate; atherosclerosis; flowcyte-meter; ズリ応力比

In Japan, recently, the feature of the cerebro vascular disease (CVD) has been changed, largely due to the measures of preventive CVD and the changes from Japanese traditional lifestyles to westernized lifestyles, including diet and working. At present, however, the morbidity and mortality of brain stroke were more frequent than North Americans and Europeans. The aim of this study was to investigate new methods of the prevention of the cardiovascular disease.In this study, the activation of IL-6 receptor was association with the plaque indexes of the carotid ultrasonography. And increase of the share rate was association with plaques. This result shows that mechanical function of blood flow irritates the atherosclerotic changes through of the immuno-inflammation responses. By the case-control study, there was significantly relation between indexes of carotid ultrasonography and brain infarction. But there were some limits about this result. The association with the lacunar infarction was slightly below that of the large artery infarction. Moreover, among Japanese, the measurement of the carotid ultrasonography simultaneously with the IL-6 should be emphasized for screening method of the brain infarction.The other analysis of this study, the exercise was negative association with atherosclerotic changes of the carotid artery. There for, the preserving exercise was the measure of preventive atherosclerosis and CVD.

近年来，日本脑血管疾病(CVD)的特点发生了变化，这在很大程度上是由于预防CVD的措施以及日本人的传统生活方式向西方化生活方式的转变，包括饮食和工作。然而，目前，卒中的发病率和死亡率高于北美和欧洲人。本研究的目的是探讨预防心血管疾病的新方法。在本研究中，IL-6受体的激活与颈动脉超声斑块指数相关。分担率的增加与斑块的形成有关。这一结果表明血流的机械功能通过免疫炎症反应刺激动脉粥样硬化的改变。经病例对照研究，颈动脉超声各指标与脑梗塞有显著相关性。但这一结果也有一些局限性。与腔隙性脑梗塞的相关性略低于大动脉脑梗塞。此外，在日本人中，脑梗塞的筛查方法应强调同时测量颈动脉超声和IL-6。本研究的另一项分析显示，运动与颈动脉粥样硬化改变呈负相关。因此，保健性运动是预防动脉粥样硬化和心血管疾病的措施。

项目成果

岡田克俊, 加藤匡宏, 藤本弘一郎, 竇貴旺, 浅井芳恵, 小西正光: "循環器疾患スクリーニング検査としての頸動脈超音波検査の検討(第3報)"四国の農村医学2. 26. 113-117 (2001)

Katsutoshi Okada、Masahiro Kato、Koichiro Fujimoto、Takao Makoto、Yoshie Asai、Masamitsu Konishi：“颈动脉超声作为心血管疾病筛查试验的研究（第三次报告）”四国农村医学 2. 26. 113-117（2001 年）

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Konishi, M., Kondo, H., Okada, K., et al.: "Health Status, Life Habits, and Social Background among the JPHC Study Particiants at Base Line Survey."Journal of Epidemiology.. 11・6. 57-74 (2001)

小西 M.、近藤 H.、冈田 K. 等：“基线调查中 JPHC 研究参与者的健康状况、生活习惯和社会背景”。流行病学杂志.. 11・6。 -74 (2001)

Okada K.Fujimoto K, Konishi M, et al.: "Evidence Based Public Health"EMS. 21・4. 341-350 (2002)

冈田 K.Fujimoto K、小西 M 等：“基于证据的公共卫生”EMS 21・4（2002 年）。