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Comprehensive researches to establish objective diagnostics of atypical psychosis

建立非典型精神病客观诊断的综合研究

基本信息

批准号：
15390350
负责人：
HAYASHI Takuji
金额：
$ 9.02万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390350/
关键词：
Atypical psychoses Schizophrenia Auditory hallucination SPECT WRI NIRS Exploratory eye movement Event-related potential 内因性精神病統合失調症 NIRS 診断

项目摘要

To establish an objective diagnostic approach to atypical psychosis, we have been investigating not only the psychopathological differences but also the biological basis of typical schizophrenia and atypical psychoses using brain imaging techniques, such as CT, SPECT, MRI and NIRS, and psycho-physiological methods, such as exploratory eye movement and event-related potentials.On NIRS studies, there were no apparent differences between atypical psychoses (N=18) and typical schizophrenia patients (N=13) during verbal fluency task, although there were significant differences between the two patient groups and controls (N=23). Because there was marked variance in our NIRS data, we must accumulate and analyze more cases than in the present study. In addition, it is also necessary to examine technical problems that cause instability of the data.On SPECT study, we previously reported hypo-function in the frontal region of schizophrenias and in the right thalamus of atypical psychosis patients. These findings are thought to indicate an important difference between the two patient groups. However, these were no tangible findings that would confirm the diagnosis of atypical psychoses in individual patients.Recently, we reported several brain imaging findings in schizophrenia using 3.0T-MRI. However, the sample size is still small, and we cannot yet classify the patients into 2 patients groups. We intend to continue these MRI studies with a larger sample-size.In psychopathology research, we analyzed patients with auditory hallucination, and identified the characteristics and differences in auditory hallucination between schizophrenia and atypical psychoses patients.

为了建立一种非典型精神病的客观诊断方法，我们利用CT、SPECT、MRI和NIRS等脑成像技术，以及探索性眼球运动和事件相关电位等心理生理学方法，对典型精神分裂症和非典型精神病的精神病理差异和生物学基础进行了研究。在近红外光谱研究中，非典型精神病(N=18)和典型精神分裂症患者(N=13)在言语流利性任务上没有明显差异，尽管两组患者和对照组(N=23)之间存在显著差异。由于我们的近红外光谱数据存在显著差异，我们必须积累和分析比目前研究更多的病例。此外，还有必要检查导致数据不稳定的技术问题。在SPECT研究中，我们先前报告了精神分裂症患者额区和非典型精神病患者的右侧丘脑功能低下。这些发现被认为表明了这两组患者之间的一个重要差异。然而，这些都不是明确的发现，可以证实个别患者患有非典型精神病的诊断。最近，我们报告了几个精神分裂症患者使用3.0T-MRI的脑成像结果。然而，样本量仍然很小，我们还不能将患者分为两个患者组。在精神病理学研究中，我们对幻听患者进行了分析，找出了精神分裂症和非典型精神病患者的幻听特征和差异。