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Clinico-psychopathological and brain imaging studies in atypical psychosis

非典型精神病的临床心理病理学和脑成像研究

基本信息

批准号：
06670984
负责人：
HAYASHI Takuji
金额：
$ 1.34万
依托单位：
Aichi Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1996
项目状态：
已结题

项目摘要

In order to reconsider atypical psychosis (Mitsuda) using ICD-10 criteria, we investigated 351 patients with psychotic symptoms, who were admitted to the psychiatric ward of Aichi Medical University Hospital from 1982 to 1991. These patients were diagnosed by the criteria of Mitsuda and ICD-10 (JCM : Japanese clinical modification), respectively, and the clinical features, family history and precipitating factors (judged to be colsely related to the onset of the illness) were examined. The results obtained are as follows.1) Atypical psychoses in either criteria are mainly composed of acute transient psychotic disorder (F23) and schizoaffective psychosis (F25). However, there are some differences between the two diagnostic systems. Atypical psychosis (JCM) excludes and acute schizophrenia-like psychotic disorder (F23.2). On the other hand, Mitsuda's atypical psychosis includes these psychoses.2) Schneider's first-rank symptoms are frequently found not only in schizophrenics but in atypi … More cal psychotics. Auditory hallucinations and self-disturbances are more frequently encountered in schizophrenics, whereas delusional perception is more frequently found in atypical psychotics.3) Atypical psychosis (Mitsuda) patients have more first-degree relatives with psychiatric disorders than schizophrenics. On the other hand, atypical psychosis (JCM) patients have significantly more relatives with psychiatric disorders, especially with affective disorders, than schizophrenics.4) Precipitating factors were found more frequently in both categories of patients with atypical psychosis than in schizophrenics.5) On the subdivisions of atypical psychosis, acute schizophrenia-like psychotic disorder (ICD : F23.2) patients have less family history than the other acute psychoses patients and schizophrenics, As for preipitating factors, they have them more frequently than the other acute psychoses patients, especially schizophrenics. On the contrary, patients with acute polymorphic psychotic disorder with symptoms of schizophrenia (F23.1) have more family history and fewer precipitating factors. Therefore, these two subtypes of atypical psychosis seem to have contrasting positions.The present studies suggest that atypical psychosis is different disease entity from schizophrenia, and that this pyschosis is not homogeneous disease, therefore, further subclasification is warranted. Less

为了重新考虑非典型精神病（Mitsuda）使用ICD-10标准，我们调查了351例精神病症状，谁被收住的精神科病房的爱知医科大学医院从1982年至1991年。这些患者分别按Mitsuda和ICD-10（JCM：日本临床修订版）诊断标准进行诊断，并检查了临床特征、家族史和与发病密切相关的促发因素。结果表明：（1）两种标准中的非典型精神病主要由急性短暂性精神病性障碍（F23）和情感性精神病（F25）组成。然而，这两种诊断系统之间存在一些差异。非典型精神病（JCM）不包括急性精神分裂样精神障碍（F23.2）。另一方面，Mitsuda的非典型精神病包括这些精神病。2）Schneider的第一级症状不仅经常出现在精神分裂症患者中，也经常出现在精神分裂症患者中。 ...更多信息卡尔精神病精神分裂症患者更易出现幻听和自我干扰，而妄想性知觉则更易出现在非典型精神病患者中。3）非典型精神病患者的一级亲属中精神障碍患者多于精神分裂症患者。非典型精神病（JCM）患者的亲属中精神障碍（尤其是情感障碍）的比例显著高于精神分裂症患者; 4）两类非典型精神病患者的发病因素均高于精神分裂症患者; 5）在非典型精神病的亚类中，急性精神分裂症样精神障碍（acute schizophrenia-like psychotic disorder，ACMD）和精神分裂症样精神障碍（acute schizophrenia-like psychotic disorder，ACMD）的发病率高于精神分裂症患者（ICD：F23.2）患者的家族史较其他急性精神病患者和精神分裂症患者少，其诱发因素较其他急性精神病患者，尤其是精神分裂症患者多。而急性多态性精神障碍伴精神分裂症症状者（F23.1）家族史多，诱因少。因此，这两种亚型的不典型精神病似乎有着截然不同的地位，目前的研究表明，不典型精神病是与精神分裂症不同的疾病实体，这种精神分裂症不是同质的疾病，因此，进一步细分是必要的。少