Study of Time Compression Phenomenon In Auditory Sensory Memory for Schizophrenic Patients

精神分裂症患者听觉感觉记忆时间压缩现象的研究

• 批准号: 15390346
• 负责人: YABE Hirooki
• 金额: $ 4.48万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390346/
• 关键词: MMN; auditory sensory memory; temporal window of integration; temporal compression; EEG; MEG; Schizophrenia

The man developed the defensive auditory mechanism to automatically detect the incoming abnormal sounds. This system was revealed by investigating the mismatch negativity (MMN) in the auditory cortex. The change-detection system as reflected by the MMN requires the storage of the previous state of the acoustic environment for detecting a deviating sound. According to the memory trace theory, MMN is generated by the comparison process between sound change and the neural trace of the frequent preceding stimuli stored in sensory memory. Such an event-storage is related to the brain mechanism termed the temporal window of integration (TWI) which integrates the closely presented sounds into single information units. Based on the temporal integration theory, we found that the memory trace should be represented as time-functional information of 160-170 ms (1997,1998,1999, ＆ 2001).In this research project, we evaluated precisely the change of deviation-detection sensitivity inside sensory memory as a function of time, which is reflected by TWI (2004), and found time might be compressed in the neural trace of sound (2005). In addition, we found the cognitive function reflected by transient gamma-band response should be dissociated from that reflected by MMN (2005). We reported the probability effect on the development of memory trace (2006). We also revealed the impairment in activation of a frontal attention-switch mechanism in schizophrenics (2004), and investigated the temporally integrative functions (or time flow) of auditory sensory memory in schizophrenia. Consequently, we found that schizophrenia should cause the impaired temporal function in the sensory memory. A part of the findings were presented in several symposiums (2nd SICPB2006,IPEG2006,8th IEPS, MMN2003,36th Japanese clinical neurophysiology congress). All of the results will be reported until the end of 2007 school year.

这个人开发了防御性听觉机制，可以自动检测传入的异常声音。通过对听觉皮层失匹配负波（MMN）的研究，揭示了这一系统。由MMN反映的变化检测系统需要存储声学环境的先前状态以检测偏离的声音。根据记忆痕迹理论，MMN是通过声音变化与感官记忆中存储的频繁的前刺激的神经痕迹进行比较的过程而产生的。这种事件存储与被称为整合时间窗（TWI）的大脑机制有关，TWI将紧密呈现的声音整合成单个信息单元。基于时间整合理论，我们发现记忆痕迹应表现为160-170 ms的时间功能信息（1997，1998，1999，&2001）。在本研究项目中，我们精确地评估了感觉记忆中偏差检测灵敏度随时间的变化，这反映了TWI（2004），并发现时间可能在声音的神经轨迹中被压缩（2005）。此外，我们发现瞬态γ波反应所反映的认知功能应该与MMN（2005）所反映的认知功能相分离。2006年，我们报道了概率效应对记忆痕迹发展的影响。我们还揭示了精神分裂症患者额叶注意转换机制的激活受损（2004），并研究了精神分裂症患者听觉感觉记忆的时间整合功能（或时间流）。因此，我们发现精神分裂症可能会导致感觉记忆中的时间功能受损。部分研究结果已在多个研讨会上发表（第二届SICPB 2006、IPEG 2006、第八届IEPS、MMN 2003、第36届日本临床神经生理学大会）。所有结果将在2007学年结束前报告。

项目成果

香りの精神生理学的基盤-事象関連電位研究を中心に

气味的心理生理学基础——专注于事件相关电位研究

• 发表时间: 2006
• 期刊: 精神神経学雑誌 37
• 作者: 書間臣治;松岡貴志;朝井廉;佐藤泰治;篠崎直子;須藤武行;梨田忠良;石山哲;矢部博興;兼子直
• 通讯作者: 兼子直

Spectrotemporal window of integration of auditory information in the human brain. Brain.

人脑中听觉信息整合的频谱时间窗口。

• 发表时间: 2003
• 期刊: Res Cogn Brain Res 17
• 作者: Shinozaki N;Yabe H;Sato Y;Hiruma T;Sutoh T;Matsuoka T;Kaneko S
• 通讯作者: Kaneko S

Cortical evidence of the perceptual backward masking effect on /1/and /r/ sounds from a following vowel in Japanese speakers.

日语使用者中后续元音的 /1/ 和 /r/ 声音的感知后向掩蔽效应的皮层证据。

• 发表时间: 2003
• 期刊: Neuroimage 18
• 作者: Koyama S;Yamada R;Gunji A;Roberts TPL;Yabe H;Kakigi R
• 通讯作者: Kakigi R

Koyama S, Yamada R, Gunji A, Roberts TPL, Yabe H, Kakigi R: "Cortical evidence of the perceptual backward masking effect on /1/and/r/ sounds from a following vowel in Japaneses peakers"NeuroImage. 18. 962-974 (2003)

Koyama S、Yamada R、Gunji A、Roberts TPL、Yabe H、Kakigi R：“日本人峰值音中后续元音对 /1/ 和 /r/ 声音的感知后向掩蔽效应的皮层证据”NeuroImage。

矢部博興, 篠崎直子, 松岡貴志, 長谷川智明, 朝井廉, 佐藤泰治, 須藤武行, 晝間臣治, 兼子直: "Mismatch negativityの発生源に関する最近の知見"臨床脳波. 45. 547-551 (2003)

Hiroki Yabe、Naoko Shinozaki、Takashi Matsuoka、Tomoaki Hasekawa、Ren Asai、Yasuji Sato、Takeyuki Sudo、Omiharu Hiruma、Nao Kaneko：“失配负性起源的最新发现” 45. 547-551 (2003)。