Study of Automatic Information Processing in Schizophrenia according to Temporal Window of Integration Theory

事件相关脑电位(ERPs)的失配负性(MMN)成分反映了与自动信息加工相关的记忆过程。我们报道了MMN(Yabe等人，NeuroReport，1997)所反映的听觉感觉记忆中的“整合时间窗”的机制。另一方面，一些研究表明，精神分裂症的认知功能缺陷也反映在MMN的受损生成中。在我们之前的研究中，很少从均匀的声音序列中遗漏一个刺激只在SOA小于160-170ms时才引起MMN，TWI的持续时间(磁脑图学：MEG；Yabe等人，心理生理学，1998，Yabe等人，EEG期刊，Suppl。40,1999年；第六届IEPS：冈崎奖)。此外，我们还发现，自动检测灵敏度在TW I(Yabe et al.，Cog.Brain Res.，in Press)结束时应呈非线性下降，并且流分离的机制比TW I(Y…)更主要更多Abe等人，Brain Res.Interactive，正在印刷中)。在ICON-7专题讨论会(1999年，布达佩斯)上介绍了这两项成果。我们还研究了MMN反映的人脑中的声音分组(Shinozaki等人，NeuroReport，2000)。我们报告说，中位数方法在消除罕见伪影和识别因潜伏期抖动和不确定事件(Yabe，Ener)而模糊的信号方面应该是有效的。克莱恩。神经生理学，1993；雅贝，BRMIC，1998)。我们确定了在躯体感觉通道中MMN的等价物(Shinozaki等人，Cog.Brain Res.，1998)。我们报告说，服用抗精神病药降低了觉醒水平，这反映在早期CNV波幅的降低(Sato等人，Schizo.Res，1999)。最后，我们发现精神分裂症患者的TWI机制可能受损(2000年MMN研讨会，Barcerona，2000)。此外，我们开始了关于MMN语言的研究(Koyama等人，Cog.脑研究，2000；小山等人，NeuroReport，2000)。较少

Mismatch negativity (MMN) component of the event-related brain potentials (ERPs) reflects the memory process related to the automatic information processing. We reported the mechanism of "Temporal Window of Integration (TWI)" in auditory sensory memory as reflected by MMN (Yabe et.al., NeuroReport, 1997). On the other hand, several studies indicated that deficits of cognitive function in schizophrenia were also reflected in the impaired generation of MMN.In our previous studies, infrequently omitting one stimulus from a homogeneous sound sequence only elicited an MMN when SOA was shorter than 160-170 ms, the duration of TWI (Magnetoencephalography : MEG ; Yabe et.al., Psychophysiology, 1998, Yabe et.al., EEG journal, suppl. 40, 1999 ; 6th IEPS : Okazaki Award). Furthermore, we found that automatic detection sensitivity should decline nonlinearly toward the end of TWI (Yabe et.al., Cog.Brain Res., in press) and that the mechanism of Stream Segregation be more primary than that of TWI (Y … More abe et.al., Brain Res. Interactive, in press). Both results were presented in the symposium of ICON-7(1999, Budapest). We also investigated sound grouping in human brain as reflected by MMN (Shinozaki et.al., NeuroReport, 2000). We reported that Median Method should be effective in eliminating infrequent artifacts and identifying the signals blurred by latency jitter and uncertain occurrence (Yabe, Electroencephr. Clin. Neurophysiol., 1993 ; Yabe, BRMIC, 1998). We identified the equivalent of MMN in somatosensory modality (Shinozaki et.al., Cog.Brain Res., 1998). We reported that the administration of neuroleptic drugs decreased the arousal level, as reflected in a reduction of early CNV amplitude (Sato et.al., Schizo.Res., 1999). Finally, we found that the TWI mechanism might be impaired in schizophrenia (Symposium of MMN 2000, Barcerona, 2000). Additionally, we started the studies concerning the language MMN (Koyama et al., Cog. Brain Research, 2000 ; Koyama et al., NeuroReport, 2000). Less