Study of Automatic Information Processing in Schizophrenia according to Temporal Window of Integration Theory

事件相关脑电位（ERPs）的错配负波（MMN）成分反映了与自动信息加工有关的记忆过程。我们报道了如MMN所反映的听觉感觉记忆中的“整合时间窗（TWI）”的机制（Yabe等人，NeuroReport，1997）。另一方面，一些研究表明，精神分裂症的认知功能缺陷也反映在MMN的产生受损中。在我们以前的研究中，当SOA短于160-170 ms时，从均匀的声音序列中偶尔省略一个刺激仅引起MMN，TWI的持续时间（脑磁图：MEG ; Yabe等人，Psychophysiology，1998年，Yabe等人，EEG杂志，增刊40，1999 ;第6届IEPS：冈崎奖）。此外，我们发现，自动检测灵敏度应在TWI结束时非线性下降（Yabe等人，Cog.Brain Res.，流场偏析机制比TWI（Y）更主要 ...更多信息 Abe等人，Brain Res. Interactive，出版中）。这两项成果都在ICON-7（1999年，布达佩斯）的专题讨论会上作了介绍。我们还研究了由MMN反映的人脑中的声音分组（Shinozaki等人，NeuroReport，2000）。我们报道了中值方法在消除不常见的伪影和识别由延迟抖动和不确定发生而模糊的信号方面应该是有效的（Yabe，Electroencephr.临床神经生理学，1993 ; Yabe，BRMIC，1998）。我们在躯体感觉模态中鉴定了MMN的等同物（Shinozaki等人，Cog.Brain Res.，1998年）。我们报道了神经安定药物的给药降低了唤醒水平，如早期CNV振幅的降低所反映的（Sato et.al.，Schizo.Res.，1999年）。最后，我们发现TWI机制可能在精神分裂症中受损（Symposium of MMN 2000，Barcerona，2000）。此外，我们开始了关于语言MMN的研究（Koyama等人，齿轮Brain Research，2000 ; Koyama等人，NeuroReport，2000）。少

Mismatch negativity (MMN) component of the event-related brain potentials (ERPs) reflects the memory process related to the automatic information processing. We reported the mechanism of "Temporal Window of Integration (TWI)" in auditory sensory memory as reflected by MMN (Yabe et.al., NeuroReport, 1997). On the other hand, several studies indicated that deficits of cognitive function in schizophrenia were also reflected in the impaired generation of MMN.In our previous studies, infrequently omitting one stimulus from a homogeneous sound sequence only elicited an MMN when SOA was shorter than 160-170 ms, the duration of TWI (Magnetoencephalography : MEG ; Yabe et.al., Psychophysiology, 1998, Yabe et.al., EEG journal, suppl. 40, 1999 ; 6th IEPS : Okazaki Award). Furthermore, we found that automatic detection sensitivity should decline nonlinearly toward the end of TWI (Yabe et.al., Cog.Brain Res., in press) and that the mechanism of Stream Segregation be more primary than that of TWI (Y … More abe et.al., Brain Res. Interactive, in press). Both results were presented in the symposium of ICON-7(1999, Budapest). We also investigated sound grouping in human brain as reflected by MMN (Shinozaki et.al., NeuroReport, 2000). We reported that Median Method should be effective in eliminating infrequent artifacts and identifying the signals blurred by latency jitter and uncertain occurrence (Yabe, Electroencephr. Clin. Neurophysiol., 1993 ; Yabe, BRMIC, 1998). We identified the equivalent of MMN in somatosensory modality (Shinozaki et.al., Cog.Brain Res., 1998). We reported that the administration of neuroleptic drugs decreased the arousal level, as reflected in a reduction of early CNV amplitude (Sato et.al., Schizo.Res., 1999). Finally, we found that the TWI mechanism might be impaired in schizophrenia (Symposium of MMN 2000, Barcerona, 2000). Additionally, we started the studies concerning the language MMN (Koyama et al., Cog. Brain Research, 2000 ; Koyama et al., NeuroReport, 2000). Less