Study of Automatic Information Processing in Schizophrenia according to Temporal Window of Integration Theory

事件相关脑电位（ERPs）中的失配负性（MMN）分量反映了与自动信息加工相关的记忆过程。我们报道了MMN在听觉感觉记忆中反映的“时间整合窗口（Temporal Window of Integration， TWI）”机制（Yabe等）。， NeuroReport, 1997)。另一方面，一些研究表明，精神分裂症患者的认知功能缺陷也反映在MMN的生成受损上。在我们之前的研究中，很少从均匀的声音序列中省略一个刺激，只有当SOA短于160-170 ms （TWI的持续时间）时才会引发MMN（脑磁图：MEG； Yabe等）。，心理生理学，1998，Yabe等。，脑电图杂志，增刊。1999年4月40日；第六届IEPS：冈崎奖)。此外，我们发现自动检测灵敏度在TWI结束时呈非线性下降（Yabe等）。齿轮。Brain Res., in press)和流隔离的机制比TWI （Y…more abe等）更主要。， Brain Res. Interactive，出版中)。这两项结果都在ICON-7专题讨论会（1999年，布达佩斯）上提出。我们还研究了MMN （Shinozaki et.al）所反映的人脑声音分组。， NeuroReport, 2000)。我们报道中值法在消除不常见的伪影和识别由延迟抖动和不确定发生模糊的信号方面应该是有效的(Yabe, Electroencephr。中国。Neurophysiol。， 1993年；Yabe， BRMIC, 1998)。我们在体感觉模态中发现了MMN的等效物（Shinozaki等人）。齿轮。Brain Res., 1998)。我们报告说，服用抗精神病药物降低了觉醒水平，这反映在早期CNV振幅的降低上（Sato等）。, Schizo.Res。, 1999)。最后，我们发现精神分裂症患者的TWI机制可能受损（Symposium of MMN 2000, barcelona, 2000）。此外，我们开始了关于语言MMN的研究（Koyama et al., Cog）。大脑研究，2000；Koyama等人，NeuroReport, 2000)。少

Mismatch negativity (MMN) component of the event-related brain potentials (ERPs) reflects the memory process related to the automatic information processing. We reported the mechanism of "Temporal Window of Integration (TWI)" in auditory sensory memory as reflected by MMN (Yabe et.al., NeuroReport, 1997). On the other hand, several studies indicated that deficits of cognitive function in schizophrenia were also reflected in the impaired generation of MMN.In our previous studies, infrequently omitting one stimulus from a homogeneous sound sequence only elicited an MMN when SOA was shorter than 160-170 ms, the duration of TWI (Magnetoencephalography : MEG ; Yabe et.al., Psychophysiology, 1998, Yabe et.al., EEG journal, suppl. 40, 1999 ; 6th IEPS : Okazaki Award). Furthermore, we found that automatic detection sensitivity should decline nonlinearly toward the end of TWI (Yabe et.al., Cog.Brain Res., in press) and that the mechanism of Stream Segregation be more primary than that of TWI (Y … More abe et.al., Brain Res. Interactive, in press). Both results were presented in the symposium of ICON-7(1999, Budapest). We also investigated sound grouping in human brain as reflected by MMN (Shinozaki et.al., NeuroReport, 2000). We reported that Median Method should be effective in eliminating infrequent artifacts and identifying the signals blurred by latency jitter and uncertain occurrence (Yabe, Electroencephr. Clin. Neurophysiol., 1993 ; Yabe, BRMIC, 1998). We identified the equivalent of MMN in somatosensory modality (Shinozaki et.al., Cog.Brain Res., 1998). We reported that the administration of neuroleptic drugs decreased the arousal level, as reflected in a reduction of early CNV amplitude (Sato et.al., Schizo.Res., 1999). Finally, we found that the TWI mechanism might be impaired in schizophrenia (Symposium of MMN 2000, Barcerona, 2000). Additionally, we started the studies concerning the language MMN (Koyama et al., Cog. Brain Research, 2000 ; Koyama et al., NeuroReport, 2000). Less