Study of time-functional abnormality in the inside of sensory memory in schizophrenia

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Human being has developed automatic defensive mechanism in the acoustic brain to detect the deviated sounds coming from the dangerous events. The sensory memory underlying this mechanism is reflected by the mismatch negativity(MMN) located in the vicinity of the primary auditory cortex. Our previous MMN findings strongly supports that the of preceding sounds is integrated into the sensory memory as a time-wise neural image 160-170ms epoch. The flow of time in the real world may differ from the one in the neural representation of auditory scene stored in the sensory memory, because the neutrally encoded information is free from the rule of actual time.We found that the impaired MMN in schizophrenia might be caused by the abnormality of time-functional neural trace related to the dysfunction of temporal integration window(TWI) by measuring MMN with special TWI paradigm.(in submission)