An experimental study about development of the ventilator for total liquid ventilation and its optimal respiratory setting.

全液体通气呼吸机研制及其最佳呼吸设置的实验研究。

• 批准号: 15390416
• 负责人: AOE Motoi
• 金额: $ 9.22万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390416/
• 关键词: Liquid Ventilation; Respiratory Assist; Respiratory Failure; Animal Experiment; Artificial Ventilation; Membrane Oxygenator; Perfluorocarbon; Acute Lung Injury; 液体換気; 全液体呼吸; 完全液体呼吸; パーフロロカーボン; 医療器械; 医療工学; 呼吸生理; 呼吸条件

However, Total Liquid Ventilation (TLV)is an effective treatment for ARDS, there still remain the problem about C02 removal. The C02 Removal performance depends on the pressure difference between Liquid side and Gas side in a membrane lung. In this study, we newly developed an oxygenator for TLV (TLV-OX)to improve this problem.We examined Gas Exchange Performance (GEP)in vitro. In newly developed TLV-OX, the gas flow length was shortened to 50mm from 160mm, and gas inlets were increased to flow fresh 100%02 gas constantly. GEP was evaluated using the single path method under PFC (Perfluorocarbon) flow rate of Q=0.75 L/min and gas flow ratio/PFC flow ratio of V/Q =3,9,15,18,and calculated by the equation(1) :GEP=(difference in P02 or PCO2 between inlet and outlet of TLV-OX/atmosphere pressure (760mmHg))X bunsen coefficient X Q (1)The newly developed TLV-OX was shown to be 22.5mL/min, and the previous TLV-OX was 18.9mL/min in V/Q =18.GEP the of newly developed TLV-OX was increased by 15.9% compared with the previous TLV-OX.In conclusion, it was considered that the difference in PCO2 between PFC and blood was kept at a high level by shortening the gas flow length and with an increase of gas inlets.We will optimize TLV-OX design to offer a high GEP using a Multi Objective Genetic Algorithm.

然而，全液体呼吸机(TLV)是治疗ARDS的一种有效方法，但仍存在二氧化碳清除问题。膜肺内液侧和气侧的压差决定了脱除CO_2的效果。在本研究中，我们开发了一种用于TLV的氧合器(TLV-OX)来改善这一问题。我们在体外测试了气体交换性能(GEP)。在新开发的TLV-OX中，气体流动长度从160 mm缩短到50 mm，并增加了气体入口，以持续流动100%新鲜的02气体。在全氟化碳流量Q=0.75 L/分钟，气体流量比/气体流量比V/Q=3，9，15，18的条件下，用单路法计算了GEP，并用公式(1)计算GEP=(TLV-OX进出口的P02或PCO_2差/大气压(760 Mm Hg))X本生系数X Q(1)新研制的TLV-OX为22.5毫升/分钟，在V/Q=18时，原TLV-OX为18.9mL/min。新研制的TLV-OX的GEP比TLV-OX提高了15.9%。综上所述，通过缩短气流长度和增加进气口，PFC和血液的二氧化碳分压差保持在较高水平。

项目成果

Study on Design and Development of an Oxygenator for Total Liquid Ventilation.

全液体通气充氧器的设计与开发研究。

• 发表时间: 2006
• 期刊: 5th European Symposium on Perfluorocarbon Application and Liquid Ventilation. 5.1
• 作者: A Funakubo;et al.
• 通讯作者: et al.

Study on Development and Evaluation of a Total Liquid Ventilation System.

全液体通风系统的开发和评估研究。

• 发表时间: 2003
• 期刊: ASAIO Journal The American Society for Artificial Internal Organs 49. 2
• 作者: A Funakubo;et al.
• 通讯作者: et al.

完全液体呼吸用人工肺の開発および評価に関する研究

全液体呼吸充氧器的研制与评价研究

• 发表时间: 2005
• 期刊: 膜型肺 28
• 作者: 市川侑也;赤坂知厚;多賀一郎;谷城博之;舟久保昭夫;小森栄作
• 通讯作者: 小森栄作

DEVELOPMENT OF AN OXYGENATOR FOR TOTAL LIQUID VENTILATION

开发用于全液体通气的制氧器

• 发表时间: 2005
• 期刊: ASAIO 51巻・2号
• 作者: Yuya Ichikawa;Akio Funakubo;Eisaku Komori;Sefano Tredici;Ronald B Hirschl;Robort H Bartlett;Yasuhiro Fukui
• 通讯作者: Yasuhiro Fukui

完全液体呼吸システムと制御の関する研究

完整液体呼吸系统及控制研究

• 发表时间: 2006
• 期刊: 電気学会研究会資料(リニアドライブ研究会) LD-06・48
• 作者: 野坂康夫;舟久保昭夫;ほか
• 通讯作者: ほか