An experimental study about development of the ventilator for total liquid ventilation and its optimal respiratory setting.

全液体通气（TLV）是治疗ARDS的有效方法，但仍存在co2去除问题。膜肺的co2去除性能取决于膜肺内液侧和气侧的压差。为了改善这一问题，我们开发了一种TLV氧合剂（TLV- ox）。我们检测了体外气体交换性能（GEP）。在新开发的TLV-OX中，将气流长度从160mm缩短到50mm，并增加了进气口，以不断流动新鲜的100%02气体。在PFC （Perfluorocarbon）流量Q=0.75 L/min，气体流量比/PFC流量比V/Q =3,9,15,18的条件下，采用单路法评价GEP，由式(1)计算GEP=（TLV-OX进出口P02或PCO2差/大气压（760mmHg））X本生系数X Q(1)新开发的TLV-OX为22.5mL/min，而之前的TLV-OX在V/Q =18时为18.9mL/min。新研制的TLV-OX的GEP值较前一代TLV-OX提高了15.9%。综上所述，我们认为通过缩短气体流动长度和增加气体入口，PFC与血液的PCO2差异保持在较高水平。我们将使用多目标遗传算法优化TLV-OX设计，以提供高GEP。

However, Total Liquid Ventilation (TLV)is an effective treatment for ARDS, there still remain the problem about C02 removal. The C02 Removal performance depends on the pressure difference between Liquid side and Gas side in a membrane lung. In this study, we newly developed an oxygenator for TLV (TLV-OX)to improve this problem.We examined Gas Exchange Performance (GEP)in vitro. In newly developed TLV-OX, the gas flow length was shortened to 50mm from 160mm, and gas inlets were increased to flow fresh 100%02 gas constantly. GEP was evaluated using the single path method under PFC (Perfluorocarbon) flow rate of Q=0.75 L/min and gas flow ratio/PFC flow ratio of V/Q =3,9,15,18,and calculated by the equation(1) :GEP=(difference in P02 or PCO2 between inlet and outlet of TLV-OX/atmosphere pressure (760mmHg))X bunsen coefficient X Q (1)The newly developed TLV-OX was shown to be 22.5mL/min, and the previous TLV-OX was 18.9mL/min in V/Q =18.GEP the of newly developed TLV-OX was increased by 15.9% compared with the previous TLV-OX.In conclusion, it was considered that the difference in PCO2 between PFC and blood was kept at a high level by shortening the gas flow length and with an increase of gas inlets.We will optimize TLV-OX design to offer a high GEP using a Multi Objective Genetic Algorithm.