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The experimental study of the effects of sequential fetal acidemia on the susceptibility of circulatory failure in adulthood.

连续胎儿酸血症对成年后循环衰竭易感性影响的实验研究。

基本信息

批准号：
15390500
负责人：
OKAMURA Kunihiro
金额：
$ 10.11万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

The purpose of this research is to examine the influence of fetal circulatory failure on the fetal cardiovascular and cerebral nerve system as the adjustment system. The fetal programming hypothesis proposes that adverse conditions at periods of development may lead to adulthood disease. Evidence suggests that hypertension and ischemic cardiovascular disease, brain infarction can be acquired in uterus. One of the main causes of this disease has been considered peripheral vascular dysfunction of fetus resulting from rapid maturation to adapt those bad conditions. We investigated influences of under-nutrition on placental vascular function of sheep fetus using myography. It was revealed that dietary limitation from early gestation markedly changes placental vascular regulatory function in mid-gestation. This function showed a tendency to decline dilatation from mid-gestation. Our study indicated that Nitric oxide may play an important role in those abnormal stressful condition and after … More that the fetal blood pressure regulatory system of under-nutrition fetus in mid-to- late gestation is formed under abnormal condition (2005, Kimura Y). There is a species difference in vascular pharmacological function. We checked the vascular reaction of human placenta at delivery. The same dilatation reaction of vessels of human placenta was noticed in late gestation of normal fetus. (2006 Imai N, Okamura K) And to investigate the effect of circulatory failure of fetus on cerebral nerve system, we examined the changes in electrocorticogram (ECoG), cartid artery blood flow, and arterial blood pressure of a sheep fetus during cord compression. A characteristics burst of ECoG spikes emerged during cord compression at fetal arterial pH 7.18 even before the pH went down to severe fetal acidemia. These results suggest that this abnormal brain excitement caused by mild circulatory failure can lead to fetal brain dysfunction, if cord compression is repeated or prolonged (2006 Takahash T, Okamura K). Less

本研究的目的是探讨胎儿循环衰竭对胎儿心脑神经系统作为调节系统的影响。胎儿编程假说提出，发育时期的不利条件可能导致成年期疾病。有证据表明，高血压、缺血性心血管疾病、脑梗塞等均可在子宫内获得。这种疾病的主要原因之一被认为是胎儿因快速成熟以适应这些不良条件而导致的周围血管功能障碍。我们利用肌电图研究了营养不良对绵羊胎儿胎盘血管功能的影响。研究表明，妊娠早期的饮食限制会显着改变妊娠中期的胎盘血管调节功能。该功能显示出从妊娠中期开始扩张下降的趋势。我们的研究表明，一氧化氮可能在异常应激状态下发挥重要作用，并且妊娠中晚期营养不良胎儿的胎儿血压调节系统是在异常状态下形成的（2005，Kimura Y）。血管药理功能存在物种差异。我们检查了人胎盘在分娩时的血管反应。正常胎儿妊娠后期也观察到与人胎盘血管相同的扩张反应。 (2006 Imai N, Okamura K) 为了研究胎儿循环衰竭对脑神经系统的影响，我们检查了羊胎儿在脐带受压期间皮质电图（ECoG）、颈动脉血流量和动脉血压的变化。在胎儿动脉 pH 值为 7.18 时，甚至在 pH 值下降到严重的胎儿酸血症之前，在脐带受压期间就出现了特征性的 ECoG 尖峰爆发。这些结果表明，如果重复或延长脐带受压，这种由轻度循环衰竭引起的异常大脑兴奋可能会导致胎儿大脑功能障碍（2006 Takahash T，Okamura K）。较少的