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A study of biorhythm using a power spectral analysis on the fluctuation in fetal and maternal beat-to-beat intervals

使用功率谱分析胎儿和母亲心跳间隔波动的生物节律研究

基本信息

批准号：
10470340
负责人：
OKAMURA Kunihiro
金额：
$ 0.45万
依托单位：
TOHOKU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 1999
项目状态：
已结题

项目摘要

Six normal fetuses and expectant mothers in the third-trimester pregnancy and seven IUGR fetuses were studied. In the normal group, the mother and the fetus were monitored simultaneously, while in IUGR group only the fetus was monitored continuously for the period of 24 hours on a beat-to-beat basis. A power spectrum analysis was carried out on the fluctuations in fetal beat-to-beat intervals. Over the period of 24 hours, an LF area, integrated low frequency domain (0.025-0.125 cycle/beat), was calculated for every ten minutes, and the average of six LF areas was defined as the LF area for the hour. By plotting these 24 average LF areas obtained for one day, a curve showing the fluctuations in LF areas over the period of 24 hours was drawn. To detect periodic components of a fetal rhythm of the fluctuations in one day, a spectral analysis was carried out on the fluctuations of hourly fluctuation. Then, rhythms of the fluctuations in LF areas were detected by using the cosinor method. In the mother same procedure was performed to identify periodic components.A 12-hour-period rhythm and a 24-hour-period rhythm were found in the activities of the autonomic nervous system of the normal fetuses. In IUGR fetuses, these rhythms were not observed because of the small amplitude. A 12-hour-period rhythm was not observed in the mother.Fetal rhythms of 12 hours cycle in autonomic activity seems to be characteristic, which was not observed in the mother.

对6例正常胎儿和7例IUGR胎儿进行了研究。正常组采用母儿同时监护，IUGR组采用胎心搏动连续监护24 h。功率谱分析进行了胎儿心跳间隔的波动。在24小时内，每10分钟计算一次LF面积，积分低频域（0.025-0.125周/拍），并将6个LF面积的平均值定义为该小时的LF面积。通过绘制一天内获得的这24个平均LF面积，绘制了一条显示LF面积在24小时内波动的曲线。为了检测一天内波动的胎儿节律的周期性成分，对每小时波动的波动进行了频谱分析。然后，在LF区的波动的节奏检测使用余弦方法。在母亲中进行同样的程序来识别周期性成分，在正常胎儿的自主神经系统活动中发现了12小时周期节律和24小时周期节律。在IUGR胎儿中，由于振幅小，未观察到这些节律。在母体中未观察到12小时周期节律，胎儿自主活动的12小时周期节律似乎是特征性的，这在母体中未观察到。