Analysis of fetal autonomic nerve activity by a power spectrum of heart beat-to-beat intervals and its application for clinical fetal monitoring

心跳间隔功率谱分析胎儿自主神经活动及其在临床胎儿监护中的应用

• 批准号: 05454437
• 负责人: OKAMURA Kunihiro
• 金额: $ 3.84万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05454437/
• 关键词: power spectral analysis; Fetus; fetal heart rate; fluctuation

Fetal heart rate monitoring has been widely used for early detection of fetal demise in current clinical settings.Interpretation of fetal heart rate tracing is sometimes indecisive, especially when the fetus is premature. In contrast to adult heart rates, frequency analysis of fetal heart rate fluctuation has been unsuccessful. We succeeded in measurement of beat-to-beat intervals of fetus using non-invasive Doppler ultrasound. A dual peak was observed in around 0.1 cycle/beat range, which mainly shows the sympathetic nerve activity of the fetus.In animal experiments, using fetal sheep, this peak designated "Low Frequency Area, LFA" is well correlated with the fetal condition. Namely, it decreases in size as fetus becomes acidosis. In clinical settings, this system may well be correlated with fetal blood gas values.In near future, this system will become alternative fetal monitoring to conventional fetal heart rate tracing.

胎心监护已被广泛应用于早期发现胎儿死亡在目前的临床设置，胎儿心率描记的解释有时是不确定的，特别是当胎儿早产。与成人心率相比，胎儿心率波动的频率分析一直不成功。我们成功地利用无创多普勒超声测量胎儿心跳间期。在0.1周/拍左右观察到一个双峰，主要显示胎儿交感神经活动，在动物实验中，用胎羊作实验，这个峰被称为低频区（LFA），与胎儿状况有很好的相关性。也就是说，随着胎儿酸中毒，它的体积减小。在临床应用中，该系统可以很好地与胎儿血气值相关联，在不久的将来，该系统将成为传统胎心监护的替代方案。

项目成果

Okamura K,Yajima A,Kimura Y: "Spectral analysis of beat-to-beatintervals of fetal heart obtained by Doppler sound." Gynecologin and Obsteric Investigation in preparation.

Okamura K、Yajima A、Kimura Y：“通过多普勒声获得的胎儿心脏逐次心跳间隔的频谱分析。”

Murotsuki J,Okamura K,et al: "Power spectral analysis of spontaneous rhythm in peripheral blood flow in frtal lamb" Acta Obst Gynaec Jpn. 45 (12). 1394-1398 (1993)

Murotsuki J、Okamura K 等人：“Frtal Lamb 外周血流自发节律的功率谱分析”Acta Obst Gynaec Jpn。

岡村 州博: "パワースペクトル解析により認められた羊胎仔末梢循環の自律的変動" 日本産婦人科学会誌. 45. 1394-1398 (1993)

Shuhiro Okamura：“通过功率谱分析观察胎儿羊末梢循环的自主波动”日本妇产科学会杂志 45. 1394-1398 (1993)。

岡村 州博、木村芳孝: "胎児心拍間隔ゆらぎの基本的時間周波数構造" 医用電子と生体工学. (投稿中).

Shuhiro Okamura、Yoshitaka Kimura：《胎心率波动的基本时频结构》医学电子与生物工程（目前已提交）。

Kimura Y,Okamura K et al: "Spectral analysis of beat-to-beat intervals of fetal heart obtained by Doppler sound" Gynecologic and Obstetric Investigation. (in preparation).

Kimura Y、Okamura K 等人：“通过多普勒声获得的胎心逐次心跳间隔的频谱分析”​​妇产科调查。