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Development of pulpal blood circulation by the simultaneous measurement of blood flow and blood oxygenation

通过同时测量血流量和血氧饱和度来发展牙髓血液循环

基本信息

批准号：
15390574
负责人：
IKAWA Motohide
金额：
$ 6.14万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15390574/
关键词：
pulp blood-flow measurement blood-oxygenation

项目摘要

The purpose of this study was to establish the simultaneous measurement of blood flow and blood oxygenation in the human pulp. Results obtained were as follows :1. A study was performed to obtain information on the detection area of pulpal blood flow (PBF) using Laser Doppler flowmetry (LDF). For this purpose, the artificial blood circulation in the root canals of extracted human upper central incisors were measured. The apical portions of examined teeth were severed and the root canals were enlarged from the apical end to the 2 mm incisal to the level of the cement-enamel junction (CEJ). Heparinized and diluted human peripheral blood was pumped through the apical foramen of the teeth, and the blood flow signal was monitored. Almost no signal was detected when the root canal was enlarged 3 or 4 mm apical to the CEJ. The blood flow signal significantly increased with the progress of root canal enlargement. The results indicated that the detection area of PBF in human teeth using LDF is limited. (168 wds)2. A study was performed to obtain information on the measurement of blood oxygenation in the human pulp. For this purpose, the intensity of transmitted-light through the extracted tooth filled with diluted blood with different oxygenation level. The transmitted-light through green light reflected the amount of blood haemoglobin, while that through red light was related with the oxygenation level of the blood in the tooth. In addion, transmitted-light photoplethysmography (TLP) through the human upper central incisors showed different characteristic between the green light and red light as the light source. (250 wds)Results indicated that TLP using different wavelengths of the light could detect the amount and the blood oxygenation level of the pulpal blood in the human teeth.

本研究的目的是建立在人牙髓血流量和血氧的同时测量。主要研究结果如下：1.为了解激光多普勒血流仪（LDF）在牙髓血流检测中的作用范围，进行了一项实验研究。为此，对离体人上中切牙根管内的人工血液循环进行了测定。切断受检牙齿的根尖部，从根尖端到2 mm切缘到牙釉质接合处（CEJ）的水平扩大根管。将肝素化和稀释的人外周血泵入牙齿的根尖孔，并监测血流信号。当根管扩大到CEJ顶端3或4mm时，几乎检测不到信号。随着根管扩大程度的加深，血流信号明显增强。结果表明，激光多普勒频移法检测人牙中PBF的范围有限。(168 wds）2.进行了一项研究，以获得有关测量人牙髓中血氧的信息。为此目的，透射光的强度通过提取的牙齿充满稀释血液与不同的氧合水平。通过绿色光的透射光反映了血液中血红蛋白的量，而通过红光的透射光与牙齿中血液的氧合水平有关。此外，以绿色光和红光为光源，通过人上中切牙的透射光体积描记（TLP）显示出不同的特征。(250结果表明，采用不同波长的光进行TLP可以检测出人牙牙髓血的量和血氧水平。