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Ocular Blood Flow Imaging for Glaucoma Assessment

用于青光眼评估的眼血流成像

基本信息

批准号：
10483638
负责人：
Abhishek Rege
金额：
$ 67.49万
依托单位：
VASOPTIC MEDICAL, INC.
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-03 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10483638
关键词：
Adult Age Angiography Axon Biological Markers Blindness Blood Vessels Blood flow Cardiac Clinic Clinical Clinical Research Color Complement Computer software Cornea Data Data Storage and Retrieval Diagnosis Diagnostic Eye Eye Development Functional Imaging Functional disorder Fundus Fundus photography Glaucoma Homeostasis Hyperoxia Image Imaging Device Impairment Individual Inhalation Laser Speckle Imaging Lasers Lighting Measurement Methods Monitor Morphology Myopia Ophthalmologist Ophthalmology Optic Disk Optical Coherence Tomography Optics Optometrist Optometry Outcome Oxygen Pathology Patients Pattern Performance Perfusion Perimetry Peripheral Phase Physiologic Intraocular Pressure Primary Open Angle Glaucoma Procedures Process Public Health Race Reporting Research Resolution Retina Retinal Ganglion Cells Safety Secure Sensitivity and Specificity Symptoms Technology Testing Thick Thinness Vision Visualization base blood flow measurement candidate marker clinically relevant data acquisition data management design early detection biomarkers frontier fundus imaging health goals imager imaging capabilities indexing innovation insight instrument macula multimodality neurovascular ocular imaging optical imaging perfusion imaging prototype recruit retinal damage retinal nerve fiber layer safety testing sex temporal measurement

项目摘要

ABSTRACT Glaucoma is one of the leading causes of blindness in adults worldwide. There is no single instrument that can diagnose glaucoma in all cases requiring a combination of methods including standard automated perimetry to assess peripheral vision, optical coherence tomography (OCT) to assess retinal nerve fiber layer (RNFL) thinning, intraocular pressure (IOP), and fundus photography to assess the cup to disc ratio. RNFL changes are challenging to assess in individuals with a high degree of myopia as well as in patients that have previously been treated with laser in the eye. Ocular blood flow (OBF) information from posterior segment, as obtained by an FDA-cleared instrument called XyCAM RI developed by us, has the potential to add insights relevant to glaucoma status that are complementary to conventional methods. Our preliminary results have demonstrated significant differences in OBF patterns in the optic disc and macular regions in glaucoma subjects and healthy controls. Our present Phase II project seeks to validate the diagnostic potential of OBF metrics obtained by XyCAM RI in the management of glaucoma through a rigorous clinical study with age-matched, race-matched, and sex-matched controls, and specifically demonstrate the usefulness of OBF-derived measurements in assessment of glaucoma in highly myopic patients. We also seek to develop and bring to market an enhanced multi-function fundus camera called the XyCAM FC for clinical use. The XyCAM FC will permit practitioners to visualize fundus photos in stereo mode to assess cup-to-disc ratio and also OBF information including the most diagnostically relevant features. As a frontier technology that complements color fundus images with video data on OBF dynamics at a high temporal resolution, the XyCAM FC offers the ability to perform reimbursable procedures of fundus photography, enable an ophthalmologist or optometrist to visualize glaucoma pathophysiology, and conduct research on development of OBF-based biomarkers for ophthalmic and systemic pathology with symptoms in the ocular vasculature.

摘要