Epidemiological study of the influence of periodontal disease on glucose control

我们分析了1998年在福冈市久山镇举行的1111名参与者的一般和牙周健康检查结果。牙周病受试者被澄清为容易有心电图异常作为心血管疾病的已知预测因子。对过去10年葡萄糖耐量试验的分析表明，随后发生葡萄糖耐量受损的受试者更有可能患有深口袋，这表明深口袋对葡萄糖耐量受损和糖尿病可能有影响。同样，日本自卫队健康检查的横断面分析表明，牙槽骨丢失越多的受试者越有可能患有糖耐量受损，支持久山研究的结果。肥胖与牙周病相关，与葡萄糖耐量试验结果无关，表明肥胖与牙周病有关。 关于我们 肥胖对牙周组织的损害可能与糖尿病不同。此外，牙周病的风险较高，在受试者表现出更多的代谢综合征的组成部分。结果表明，饮酒对牙周病的影响仅限于牙周袋深度超过1/3的受试者，吸烟与牙周病的关系显著，现在和过去的吸烟对牙周出血有抑制作用。我们正在建立从2003年到2006年每年约800名参与者的健康检查数据库。在参加2004年检查的743名参与者中，选择了约80名50岁的有/无牙周病的受试者，并检测了四种脂肪细胞因子，如TNF-α、脂联素、TNF-α和IL-6。分析这些数据与牙周状况显示，在调整肥胖指数BMI后，牙周病受试者中的β-淀粉样蛋白显着增加。由于这是最后一年的补助金，我们必须检查该队列研究的计划是否继续。少

We analyzed the results of general and periodontal health examination of 1111 participants, which was held at Hisayama town, Fukuoka in 1998. Subjects with periodontal disease were clarified to be liable to have electro-cardiographic abnormalities as known predictors of cardiovascular disease. Analysis of glucose tolerance tests past 10 years clarified that subjects who subsequently developed impaired glucose tolerance were significantly more likely to have deep pockets, suggesting a possible effect of deep pockets on impaired glucose tolerance and diabetes. Similarly a cross-sectional analysis of health examination of the Japan Self-Defense Force indicated that subjects with more alveolar bone loss were more likely to have impaired glucose tolerance, supporting the results of Hisayama study.Risk factors of periodontal disease were studied on females of Hisayama town. Obesity was associated with periodontal disease independently of the glucose tolerance tests results suggesting that ob … More esity may impair periodontal tissue from different way from diabetes. Moreover, risk of periodontal disease was higher in the subjects exhibiting more components of metabolic syndrome. Those were clarified that the effect of drinking on periodontal condition was limited to the subjects with deep periodontal pockets more than one-third of their teeth, smoking was significantly associated with periodontal disease, and that current and past smoking has a suppressive effect on bleeding on probing.We are building up data base from health examination annually held for about 800 participants since 2003 to 2006. Within 743 participants who attended 2004 examination about 80 subjects of 50s years old with/without periodontal disease were selected and four adipocytokines such as resistin, adiponectin, TNF-a, and IL-6, were examined. Analyzing these data with periodontal condition revealed that resistin significantly increased in the subjects with periodontal disease after adjusting for obesity index as BMI.This study is a long term cohort study. As this is the last year of the grant we have to check the plan of this cohort study to be continued. Less