Epidemiological study of the influence of periodontal disease on glucose control

牙周病对血糖控制影响的流行病学研究

基本信息

项目摘要

We analyzed the results of general and periodontal health examination of 1111 participants, which was held at Hisayama town, Fukuoka in 1998. Subjects with periodontal disease were clarified to be liable to have electro-cardiographic abnormalities as known predictors of cardiovascular disease. Analysis of glucose tolerance tests past 10 years clarified that subjects who subsequently developed impaired glucose tolerance were significantly more likely to have deep pockets, suggesting a possible effect of deep pockets on impaired glucose tolerance and diabetes. Similarly a cross-sectional analysis of health examination of the Japan Self-Defense Force indicated that subjects with more alveolar bone loss were more likely to have impaired glucose tolerance, supporting the results of Hisayama study.Risk factors of periodontal disease were studied on females of Hisayama town. Obesity was associated with periodontal disease independently of the glucose tolerance tests results suggesting that ob … More esity may impair periodontal tissue from different way from diabetes. Moreover, risk of periodontal disease was higher in the subjects exhibiting more components of metabolic syndrome. Those were clarified that the effect of drinking on periodontal condition was limited to the subjects with deep periodontal pockets more than one-third of their teeth, smoking was significantly associated with periodontal disease, and that current and past smoking has a suppressive effect on bleeding on probing.We are building up data base from health examination annually held for about 800 participants since 2003 to 2006. Within 743 participants who attended 2004 examination about 80 subjects of 50s years old with/without periodontal disease were selected and four adipocytokines such as resistin, adiponectin, TNF-a, and IL-6, were examined. Analyzing these data with periodontal condition revealed that resistin significantly increased in the subjects with periodontal disease after adjusting for obesity index as BMI.This study is a long term cohort study. As this is the last year of the grant we have to check the plan of this cohort study to be continued. Less
我们分析了1998年在福冈市久山镇举行的1111名参与者的一般和牙周健康检查结果。牙周病受试者被澄清为容易有心电图异常作为心血管疾病的已知预测因子。对过去10年葡萄糖耐量试验的分析表明,随后发生葡萄糖耐量受损的受试者更有可能患有深口袋,这表明深口袋对葡萄糖耐量受损和糖尿病可能有影响。同样,日本自卫队健康检查的横断面分析表明,牙槽骨丢失越多的受试者越有可能患有糖耐量受损,支持久山研究的结果。肥胖与牙周病相关,与葡萄糖耐量试验结果无关,表明肥胖与牙周病有关。 ...更多信息 肥胖对牙周组织的损害可能与糖尿病不同。此外,牙周病的风险较高,在受试者表现出更多的代谢综合征的组成部分。结果表明,饮酒对牙周病的影响仅限于牙周袋深度超过1/3的受试者,吸烟与牙周病的关系显著,现在和过去的吸烟对牙周出血有抑制作用。我们正在建立从2003年到2006年每年约800名参与者的健康检查数据库。在参加2004年检查的743名参与者中,选择了约80名50岁的有/无牙周病的受试者,并检测了四种脂肪细胞因子,如TNF-α、脂联素、TNF-α和IL-6。分析这些数据与牙周状况显示,在调整肥胖指数BMI后,牙周病受试者中的β-淀粉样蛋白显着增加。由于这是最后一年的补助金,我们必须检查该队列研究的计划是否继续。少

项目成果

期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Periodontology 2000 歯周病における生体反応(上巻)「肥満と歯周疾患に関連した代歯障害」
牙周病学2000年牙周病的生物反应(第一卷)“与肥胖和牙周病相关的替代性牙齿疾病”
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Saito T;Shimazaki Y.
  • 通讯作者:
    Shimazaki Y.
Relationship of metabolic syndrome to periodontal disease in Japanese women: The Hisayama study
  • DOI:
    10.1177/154405910708600314
  • 发表时间:
    2007-03-01
  • 期刊:
  • 影响因子:
    7.6
  • 作者:
    Shimazaki, Y.;Saito, T.;Yamashita, Y.
  • 通讯作者:
    Yamashita, Y.
Obesity and periodontal disease; circulating adipocytokine in women with periodontitis : the Hisayama study
肥胖和牙周病;
  • DOI:
  • 发表时间:
    2006
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ebisu;S;et. al.;Saito T et al.
  • 通讯作者:
    Saito T et al.
The extent of alveolar bone loss is associated with impaired glucose tolerance in Japanese men
  • DOI:
    10.1902/jop.2006.050061
  • 发表时间:
    2006-03-01
  • 期刊:
  • 影响因子:
    4.3
  • 作者:
    Saito, T.;Murakami, M.;Yamashita, Y.
  • 通讯作者:
    Yamashita, Y.
Relationship between drinking and periodontitis : the Hisayama study
饮酒与牙周炎之间的关系:久山研究
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SAITO Toshiyuki其他文献

SAITO Toshiyuki的其他文献

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{{ truncateString('SAITO Toshiyuki', 18)}}的其他基金

Imaging analysis of autophagy between periodontitis and dementia
牙周炎与痴呆自噬的影像学分析
  • 批准号:
    15K15775
  • 财政年份:
    2015
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Cohort study on the relationship between oral health and systemic health in Goto City
五岛市口腔健康与全身健康关系的队列研究
  • 批准号:
    26293443
  • 财政年份:
    2014
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Transcriptome analysis of leukocytes from sarcoma patients for helpful biomarkers
对肉瘤患者白细胞进行转录组分析以寻找有用的生物标志物
  • 批准号:
    25670544
  • 财政年份:
    2013
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Imaging analysis of periodontitis and NASH related mechanism in 3D incubating system
3D培养系统中牙周炎及NASH相关机制的影像学分析
  • 批准号:
    25670895
  • 财政年份:
    2013
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Brain atlas of the miniature pig to establish new animal model for image-assisted stereotaxic surgery.
小型猪的脑图谱为图像辅助立体定位手术建立新的动物模型。
  • 批准号:
    24500480
  • 财政年份:
    2012
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
A cohort study on the relationship between oral and systemic health conditions of island inhabitants
岛屿居民口腔与全身健康状况关系的队列研究
  • 批准号:
    22390402
  • 财政年份:
    2010
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Analysis of the posterior ramus of the spinal nerve.
脊神经后支的分析。
  • 批准号:
    22591719
  • 财政年份:
    2010
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The elucidation of the periodontosis using a three-dimensional cultivation system, and a metabolic syndrome related mechanism
利用三维培养系统阐明牙周病和代谢综合征相关机制
  • 批准号:
    21659487
  • 财政年份:
    2009
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Relationship between periodontal disease and metabolic disorders, adipokines, arteriosclerosis, and gene polymorphism in community inhabitants
社区居民牙周病与代谢紊乱、脂肪因子、动脉硬化及基因多态性的关系
  • 批准号:
    19390542
  • 财政年份:
    2007
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Relationship between aspiration pneumonia and oral conditions such as teeth, periodontal tissues, dentures and oral bacteria in the elderly.
老年人吸入性肺炎与牙齿、牙周组织、假牙、口腔细菌等口腔状况的关系。
  • 批准号:
    10671939
  • 财政年份:
    1998
  • 资助金额:
    $ 9.22万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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The Role of CA8 in Hepatic Glucose Production and Its Prospect as Type 2 Diabetes Mellitus Treatment
CA8在肝葡萄糖生成中的作用及其治疗2型糖尿病的前景
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研究外源性酮摄入对 2 型糖尿病患者的降血糖作用
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2 型糖尿病高危个体脂肪组织炎症纵向进展的决定因素:代谢组学分析的新见解
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患有 2 型糖尿病的老年人的远程医疗准备
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确定青年发病 2 型糖尿病 (IMPACT DM) 的代谢和心理社会因素和特征
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Biomarker of Pancreatic B-cell Loss Predicting Progression to Type 2 Diabetes After Gestational Diabetes
胰腺 B 细胞损失的生物标志物可预测妊娠期糖尿病后进展为 2 型糖尿病
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