Epidemiological study of the influence of periodontal disease on glucose control

我们分析了1998年在福冈久山镇举行的1111名参与者的一般和牙周健康检查结果。有牙周病的受试者容易有心电图异常，这是已知的心血管疾病的预测因子。对过去10年葡萄糖耐量试验的分析表明，随后出现葡萄糖耐量受损的受试者明显更有可能出现大口袋，这表明大口袋可能对糖耐量受损和糖尿病有影响。同样，对日本自卫队健康检查的横断面分析表明，牙槽骨丢失较多的受试者更有可能出现糖耐量受损，这支持了Hisayama研究的结果。对久山镇女性牙周病危险因素进行了调查。肥胖与牙周病的相关性独立于糖耐量试验结果，表明肥胖可能从不同的角度损害牙周组织。此外，表现出更多代谢综合征成分的受试者患牙周病的风险更高。结果表明，饮酒对牙周状况的影响仅限于牙周袋深度超过牙齿三分之一的受试者，吸烟与牙周疾病显著相关，目前和过去吸烟对探诊出血有抑制作用。从2003年至2006年，我们每年为约800名参与者进行健康检查，以建立数据库。在2004年参加检查的743名参与者中，选择了大约80名50岁的有/没有牙周病的受试者，并检查了四种脂肪细胞因子，如抵抗素、脂联素、TNF-a和IL-6。对牙周病患者的数据进行分析发现，在调整肥胖指数（BMI）后，牙周病患者的抵抗素显著增加。这项研究是一项长期队列研究。由于这是拨款的最后一年，我们必须检查这个队列研究的计划是否继续。少

We analyzed the results of general and periodontal health examination of 1111 participants, which was held at Hisayama town, Fukuoka in 1998. Subjects with periodontal disease were clarified to be liable to have electro-cardiographic abnormalities as known predictors of cardiovascular disease. Analysis of glucose tolerance tests past 10 years clarified that subjects who subsequently developed impaired glucose tolerance were significantly more likely to have deep pockets, suggesting a possible effect of deep pockets on impaired glucose tolerance and diabetes. Similarly a cross-sectional analysis of health examination of the Japan Self-Defense Force indicated that subjects with more alveolar bone loss were more likely to have impaired glucose tolerance, supporting the results of Hisayama study.Risk factors of periodontal disease were studied on females of Hisayama town. Obesity was associated with periodontal disease independently of the glucose tolerance tests results suggesting that ob … More esity may impair periodontal tissue from different way from diabetes. Moreover, risk of periodontal disease was higher in the subjects exhibiting more components of metabolic syndrome. Those were clarified that the effect of drinking on periodontal condition was limited to the subjects with deep periodontal pockets more than one-third of their teeth, smoking was significantly associated with periodontal disease, and that current and past smoking has a suppressive effect on bleeding on probing.We are building up data base from health examination annually held for about 800 participants since 2003 to 2006. Within 743 participants who attended 2004 examination about 80 subjects of 50s years old with/without periodontal disease were selected and four adipocytokines such as resistin, adiponectin, TNF-a, and IL-6, were examined. Analyzing these data with periodontal condition revealed that resistin significantly increased in the subjects with periodontal disease after adjusting for obesity index as BMI.This study is a long term cohort study. As this is the last year of the grant we have to check the plan of this cohort study to be continued. Less