Epidemiological study of the influence of periodontal disease on glucose control

我们分析了1998年在福冈市久山镇举行的1111名参与者的全身和牙周健康检查结果。研究表明，患有牙周病的受试者容易出现心电图异常，作为心血管疾病的已知预测指标。对过去10年的糖耐量测试的分析表明，后来患上糖耐量受损的受试者更有可能拥有更多的财力，这表明财力雄厚可能会对糖耐量受损和糖尿病产生影响。同样，日本自卫队健康检查的横断面分析表明，牙槽骨丢失越多的人更有可能患有糖耐量受损，这支持了Hisayama的研究结果。对Hisayama镇的女性进行了牙周病风险因素的研究。肥胖与牙周病的关系独立于糖耐量测试结果，这表明ob…更多的肥胖可能会从不同于糖尿病的方式损害牙周组织。此外，表现出更多代谢综合征成分的受试者患牙周病的风险更高。这些澄清了饮酒对牙周状况的影响仅限于牙周深度超过三分之一的受试者，吸烟与牙周病显著相关，以及现在和过去吸烟对探查出血有抑制作用。我们正在建立从2003年到2006年每年对大约800名参与者进行的健康检查的数据库。在2004年参加体检的743名受试者中，选取约80名50岁左右有牙周病或无牙周病的受试者，检测抵抗素、脂联素、肿瘤坏死因子-α、白介素6等4种脂肪细胞因子。将这些数据与牙周状况进行分析，发现在调整肥胖指数作为BMI后，牙周病患者的抵抗素显着增加。本研究是一项长期队列研究。由于今年是赠款的最后一年，我们必须检查这项队列研究的计划，然后继续进行。较少

We analyzed the results of general and periodontal health examination of 1111 participants, which was held at Hisayama town, Fukuoka in 1998. Subjects with periodontal disease were clarified to be liable to have electro-cardiographic abnormalities as known predictors of cardiovascular disease. Analysis of glucose tolerance tests past 10 years clarified that subjects who subsequently developed impaired glucose tolerance were significantly more likely to have deep pockets, suggesting a possible effect of deep pockets on impaired glucose tolerance and diabetes. Similarly a cross-sectional analysis of health examination of the Japan Self-Defense Force indicated that subjects with more alveolar bone loss were more likely to have impaired glucose tolerance, supporting the results of Hisayama study.Risk factors of periodontal disease were studied on females of Hisayama town. Obesity was associated with periodontal disease independently of the glucose tolerance tests results suggesting that ob … More esity may impair periodontal tissue from different way from diabetes. Moreover, risk of periodontal disease was higher in the subjects exhibiting more components of metabolic syndrome. Those were clarified that the effect of drinking on periodontal condition was limited to the subjects with deep periodontal pockets more than one-third of their teeth, smoking was significantly associated with periodontal disease, and that current and past smoking has a suppressive effect on bleeding on probing.We are building up data base from health examination annually held for about 800 participants since 2003 to 2006. Within 743 participants who attended 2004 examination about 80 subjects of 50s years old with/without periodontal disease were selected and four adipocytokines such as resistin, adiponectin, TNF-a, and IL-6, were examined. Analyzing these data with periodontal condition revealed that resistin significantly increased in the subjects with periodontal disease after adjusting for obesity index as BMI.This study is a long term cohort study. As this is the last year of the grant we have to check the plan of this cohort study to be continued. Less