The elucidation of the periodontosis using a three-dimensional cultivation system, and a metabolic syndrome related mechanism

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Periodontal disease is local inflammation caused by periodontal pathogens and an association with immuno-response including various cytokines and activation of osteoclast has been clarified. On the other hand, it is reported that periodontal disease is associated with diabetes, arteriosclerosis, and cardiovascular disease, beyond periodontal inflammation and destruction, however, its mechanism has not been clarified well. In this study we hypothesized that periodontal disease has bad effects on glucose and lipid metabolism in the liver(Periodontol 2000 2007 : 43 : 254-66 Review). From a point of view that periodontal disease and various metabolic disorders affect each other, in order to clarify this, we examined it using 3 dimensional culture system in vitro. As a result, stimulation by LPS derived from periodontal pathogens has bad effects on release of resistin and adiponectin from adipocyte and macrophages. These phenomena were suggested to be one of mechanisms that periodontal disease influence systemic disease.