权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Carcinogenic risk assessment of arsenic poisoning in Bangladesh and ingestion of organo-arsenic in Japan.

孟加拉国砷中毒和日本有机砷摄入的致癌风险评估。

基本信息

批准号：
15406029
负责人：
ENDO Ginji
金额：
$ 8.51万
依托单位：
Osaka City University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

The purpose of this study was to examine the association between current arsenic level of well water and urinary arsenic concentration to examine the effectiveness of Bangladeshi mitigation programs. A community-based cross-sectional study was conducted in the Pabna district of Bangladesh between May and July 2005. We included 174 married couples and collected their drinking water from 138 wells. Of 326 subjects, 304 cases exceeded urinary arsenic level of 40μg/1.5L/day. Of all wells, 23.1% wells had arsenic level >50 μg/L. Multiple-adjusted odds ratio of urinary arsenic level >40μg/1.5L/day were 8.90 (95% CI : 3.31-23.93) for arsenic level of well water of 11-50 μg/L and 53.07 (11.91-236.46) for that of 51.332 μg/L as compared with that of 【less than or equal】10 μg/L. These results suggest that arsenic level of well water of 11.50 μg/L that Bangladesh government regarded as safe were not safe.We performed speciation analysis of urinary arsenic for 210 Japanese male subjects without occupational exposure using HPLC-ICP-MS. The median values of urinary arsenics were as follows : sodium arsenite (AsIII),3.5 ; sodium arsenate (AsV), 0.1 ; monomethylarsonic acid (MMA), 3.1 ; dimethylarsinic acid (DMA), 42.6 ; arsenobetaine (AsBe), 61.3 ; arsenocholine, trimethylarsine oxide, and unidentified arsenics (others), 5.2 ; and total arsenic (total As), 141.3 μgAs/1. It appears that the high levels of DMA and AsBe observed in Japan may be due in part to seafood intake.To clarify the risks of Hijiki ingestion, a 42-year-old male volunteer ingested 825 μg of iAs compounds contained in eight servings of commercial Hijiki food, after refraining from eating seafood for 3 months. The total amounts of AsV, AsIII, MMA and DMA excreted in urine over 50 h were 11.2, 31.8, 40.9 and 104.0 μg, respectively. Long-term ingestion of Hijiki might thus have the potential to cause arsenic poisoning.

这项研究的目的是检查当前井水砷水平和尿砷浓度之间的关系，以检查孟加拉国缓解计划的有效性。2005年5月至7月，在孟加拉国帕布纳区进行了一项以社区为基础的横断面研究。我们包括174对已婚夫妇，从138口井中收集他们的饮用水。尿砷>40μg/1.5L/d者304例。在所有井中，23.1%井的尿砷水平与GT；50μg/L；井水砷浓度为11~50μg/L为8.90(95%CI：3.31~23.93)，低于10μg/L井水砷浓度为51.332μg/L为53.07(11.91~236.46)。结果表明，孟加拉国政府认为安全的井水砷浓度为11.50μg/L是不安全的。尿砷中位数如下：亚砷酸钠(AsIII)，3.5；亚砷酸钠(ASV)，0.1；单甲基砷酸(MMA)，3.1；二甲基砷酸(DMA)，42.6；砷甜菜碱(ASBE)，61.3；砷胆碱，三甲基氧化砷，以及不明原因的砷(其他)，5.2；和总砷(总砷)，141.3μ气体/1。看来，在日本观察到的高水平的二甲基甲酸和天冬氨酸可能部分是由于海鲜摄入。为了阐明摄入海鲜的风险，一名42岁的男性志愿者在3个月内不吃海鲜后，摄入了8份商业海鲜中含有的825μg的亚硫酸盐化合物。尿中ASV、AsIII、甲基丙烯酸甲酯和二甲双酯的排泄量分别为11.2、31.8、40.9和104.0μg。因此，长期摄入Hijiki可能会导致砷中毒。