Study on the Bio-effect of Ultrasound and Contrast Agents to the Scavenger Cell.

我们研究了超声和造影剂对肝细胞的生物效应。在对照组和对照组中，表达cd62p的血小板百分比均增加，而在Levovist组中表达cd62p的血小板百分比更高。我们观察到两组肝细胞空泡形成和圆形沉积。DD-723组大鼠Kupffer细胞和少量肝细胞中意外出现微泡，而Levovist组大鼠Kupffer细胞和肝细胞均未出现微泡。超声和造影剂对脑动脉周围巨噬细胞（荧光颗粒状上皮细胞）的生物效应表现为溶酶体的增加、损伤和水肿改变。结论对比剂Levovist、DD-723和Optizone对大鼠肝细胞和脑动脉周围巨噬细胞产生血小板活化和结构改变，但只有DD-723的微泡被Kupffer细胞和少数肝细胞占据。在脑内，超声和造影剂显示巨噬细胞的损伤，巨噬细胞是血脑屏障的一部分。

We studied the bio-effects of Ultrasound and contrast agents to hepatic cells. The percentage of CD62P-expressing platelets increased in both contrast USE groups, and the percentage of CD62P-expressing platelets was greater in Levovist group. We observed vacuolation and round deposits in the hepatocytes in both contrast-USE groups. Microbubbles were observed in the rat Kupffer cells and a few hepatocytes unexpectedly in the DD-723 group, but were found in neither the Kupffer cells nor the hepatocytes in the Levovist group.The bio-effects of the ultrasound and contrast agents to the Macrophage, which is named of Fluorescent Granular Perithelial Cells, around brain arteries can be seen for as increase and damage of Lysosome and edematic changes.Conclusion the contrast agents, Levovist, DD-723 and Optizone, produced platelet activation and structural change in the rat hepatic cells and the macrophages around brain arteries, but only the microbubbles of DD-723 were taken up by the Kupffer cells and a few hepatocytes. In the brain, Ultrasound and contrast agents give the damage of Macrophage which is a part of Blood-Brain Barrier.