Community-based randomized controlled trial on risk reduction for cardiovascular disease by therapeutic life-style change

这项随机对照初级预防研究旨在增加身体活动和改变治疗性生活方式，以降低心血管疾病的风险，促进年龄在40至69岁之间的无症状绝经期男性和女性的健康。在知情同意的情况下，共招募了316名居民，并将其分为三组，包括对照组（A: 105）和干预组（B=运动；106，C=运动与饮食；105）。作为一种治疗性生活方式的改变，建议B组和C组每周增加150分钟的快走。此外，C组推荐的营养指导包括理想体重所需的最佳能量摄入、每日增加n-3多元不饱和脂肪酸摄入量至2.9g、每日增加膳食纤维2.0g。所有参与者的快走都用计步器监测，该计步器可以记录至少10分钟以上的连续快走。每月向干预组提供有关治疗生活方式改变的新闻信函和讲座。1年后，重新评估风险概况，结果所有组的BMI、血清甘油三酯浓度降低，hdl -胆固醇水平升高。运动组的体力活动显著增加（B和C）。对正常人群进行健康教育的干预研究导致干预组的身体活动增加，并改善了所有组的血脂风险状况。

The randomized controlled primary prevention study to introduce increased physical activity and therapeutic life-style changes was carried out to reduce risk profile for cardiovascular disease and health promotion to asymptomatic habitants, male and female with menopause, aged 40 to 69 years old. A total of 316 habitants were recruited with informed consent, and allocated into three groups consisting control (A: 105) and interventional groups (B=exercise; 106, C=exercise with diet; 105). As a therapeutic life-style change, increased physical activity of 150 minutes brisk walking per week was recommended to B and C groups. In addition, nutritional instruction consisting of optimal energy intake for ideal body weight, increased intake of n-3 ploy-unsaturated fatty acid up to 2.9g a day and additional increase of dietary fiber by 2.0g more than ever were recommended to C group. Brisk walking of all participants was monitored by pedometer which enables to record at least more than 10 minutes continuous brisk walking. News letters and lectures on therapeutic life-style changes were provided to the interventional groups every month. After 1 year, risk profile was re-evaluated, resulting reduction of BMI, serum concentration of triglyceride and increased HDL-cholesterol levels in all groups. Physical activity was significantly increased in exercise groups (B ＆ C). The interventional study with health education for normal population induced increased physical activity in the interventional groups and ameliorated lipids risk profile in all groups.