DESIGN AND SYNTHESIS OF HIGHLY SELECTIVE ION ASSOCIATION REAGENTS BASED ON THE ANALYSIS OF AQUEOUS ION ASSOCIATION AND THEIR STUDY IN ANALYTICAL CHEMISTRY

基于水离子缔合分析的高选择性离子缔合试剂的设计与合成及其分析化学研究

• 批准号: 16350044
• 负责人: MOTOMIZU Shoji
• 金额: $ 10.24万
• 依托单位: OKAYAMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16350044/
• 关键词: ION ASSOCIATION; PLANAR DELOCALIZED MONOVALENT REAGENT; IONIC MOBILITY; MICELLAR DISTRIBUTION EQUILIBRIUM; SEPARATION OF INORGANIC IONS; BROMATE; DERIVATIZATION REACTION OF AMINES; SEPARATION OF AMINO ACIDS; アミノ酸類分離; キャピラリー電気泳動; ミセル抽出; アミン誘導体化

Ion association equilibriums in aqueous and aqueous/organic mixed solutions were analyzed, and their ion association constants were obtained by using a newly developed analysis method based on the accurate ionic mobility measurement method with capillary electrophoresis. Considering the results obtained for the ion association equilibrium, a guid principle for designing ion association reagents, the practical design and synthesis of sensitive ion association reagents and novel analytical methods based on ion association were developed, and also the concept of ion association proposed by Motomizu was much improved.(1)Accurate and precise analysis method for weak ion association equilibrium. Weak ion association equilibriums in an aqueous solution and aqueous/organic solvent mixed solutions (ethanol, dioxane and acetonitrile) were analyzed by using the proposed analysis method. The results obtained were evaluated and compared with those expected from the Bjerrum and similar equation.The … More distribution equilibrium of nitrophenolates, nitrobenzoates and aromatic sulfonates between an aqueous and a micellar phase was examined; the results were compared and explained with those of solvent extraction.(2)Development of novel ion association reagents. Highly selective and sensitive ion association reagents were developed by controlling micro-environment around ions. Especially, planar monovalent ion association reagents, which possess large molar absorptivity, were designed and synthesized. Such reagents were very stable even in alkaline solutions, and will be useful for developing sensitive and selective detection reactions for analytes in aqueous and aqueous/organic or aqueous/ micellar phase.(3)Determination of Stokes' radii, hydrophobic measure and group contribution values. Such values/measures were determined on the basis of the accurate measurement of ionic mobility in an aqueous solution by capillary electrophoresis. They are very useful for considering the hydrophobicity of ions and designing novel ion association reagents for separation and detection of analyte ions.(4)Novel methods for separation and determination of ionic substances. On the basis of ion association, novel separation/determination methods were developed : for examples, (a) determination of primary amines based on derivatization with new reagents possessing a sulfonic group, (b) determination of nitrogen-containing pharmaceutical substances after derivatization with organic sulfonate reagents, (c) trace amounts of bromate in drinking waters, (d) separation and determination of amino acids, and (e) development of novel reagents for collection/concentration reagents for metals and non-metals and their application to trace analysis. Less

分析了水溶液和水/有机混合溶液中的离子缔合平衡，并采用基于毛细管电泳精确测定离子迁移率的新分析方法获得了它们的离子缔合常数。结合离子缔合平衡的研究结果，提出了离子缔合试剂设计的指导原则、灵敏离子缔合试剂的实用设计与合成以及基于离子缔合的新分析方法，并对Motomizu提出的离子缔合概念进行了改进。（1）弱离子缔合平衡的精确分析方法。采用所提出的分析方法分析了水溶液和水/有机溶剂混合溶液（乙醇、二氧六环和乙腈）中的弱离子缔合平衡。对所得结果进行了评价，并与Bjerrum方程和类似方程的预期结果进行了比较。 ...更多信息 考察了硝基酚盐、硝基苯甲酸盐和芳香族磺酸盐在水相和胶束相之间的分配平衡，并与溶剂萃取的结果进行了比较和解释。（2）新型离子缔合试剂的开发。通过控制离子周围的微环境，研制出高选择性、高灵敏度的离子缔合试剂。特别是设计合成了具有较大摩尔吸光系数的平面型一价离子缔合试剂。这些试剂即使在碱性溶液中也非常稳定，并且将可用于开发对水相和水/有机相或水/胶束相中的分析物的灵敏和选择性检测反应。（3）Stokes半径、疏水度和基团贡献值的测定。这些值/测量值是基于通过毛细管电泳对水溶液中离子迁移率的准确测量来确定的。它们对于考虑离子的疏水性和设计用于分离和检测分析物离子的新型离子缔合试剂非常有用。（4）离子物质分离和测定的新方法。在离子缔合的基础上，开发了新的分离/测定方法：例如（a）基于用具有磺酸基的新试剂衍生化的伯胺的测定，（B）用有机磺酸盐试剂衍生化后含氮药物的测定，（c）饮用沃茨中痕量的溴酸盐，（d）氨基酸的分离和测定，以及（e）开发用于金属和非金属的收集/浓缩试剂的新型试剂及其在痕量分析中的应用。少

项目成果

Development of novel reagent for Hantzsch reaction for the determination of formaldehyde by spectrophotometry and fluorometry

• DOI: 10.2116/analsci.23.413
• 发表时间: 2007-04-01
• 期刊: ANALYTICAL SCIENCES
• 影响因子: 1.6
• 作者: Li, Qiong;Sritharathikhun, Piyanete;Motomizu, Shoji
• 通讯作者: Motomizu, Shoji

Ion-association analysis between inorganic anions and symmetrical tetraalkylammonium ions in aqueous-acetonitrile media by capillary zone electrophoresis.

通过毛细管区带电泳对水-乙腈介质中无机阴离子和对称四烷基铵离子之间的离子缔合进行分析。

• 发表时间: 2005
• 期刊: Bull. Chem. Soc. Jpn. 78
• 作者: J.Mbuna;T.Takayanagi;M.Oshima;S.Motomizu
• 通讯作者: S.Motomizu

Trace and ultratrace analysis of purified water samples and hydrogen peroxide solutions for phosphorus by flow-injection method

流动注射法对纯化水样品和过氧化氢溶液中磷的痕量和超痕量分析

• 发表时间: 2005
• 期刊: Anal.Sci 21
• 作者: Z.Li;M.Oshima;A.Sabarudin;S.Motomizu
• 通讯作者: S.Motomizu

Ion-Association Extraction of Nitrobenzoate Ions with tetrabutylammonium Ion into Nonionic Surfactant Micelles as Studied by Capillary Zone Electrophoresis

毛细管区带电泳研究硝基苯甲酸根离子与四丁基铵离子离子缔合萃取成非离子表面活性剂胶束

• 发表时间: 2007
• 期刊: Bull. Chem. Soc. Jpn. 80
• 作者: T.Takayanagi;Motomizu
• 通讯作者: Motomizu

Trace and ultratrace analysis methods for the determination of phosphorus by flow-injection techniques

• DOI: 10.1016/j.talanta.2004.12.056
• 发表时间: 2005-04-15
• 期刊: TALANTA
• 影响因子: 6.1
• 作者: Motomizu, S;Li, ZH
• 通讯作者: Li, ZH