权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Precision Synthesis and Molecular Recognition Ability of Aliphatic Polyether-type Nano-Spherical Carbohydrate Polymers

脂肪族聚醚型纳米球形碳水化合物聚合物的精密合成及分子识别能力

基本信息

批准号：
16350064
负责人：
AOI Keigo
金额：
$ 4.99万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16350064/
关键词：
dendrimer sugar ball carbohydrate polymer molecular recognition nano-materials biomedical materials drug delivery system gene delivery system

项目摘要

The present study is concerned with design, synthesis and molecular recognition of a new type of dendrimer-based polymeric nano-materials having sugar-derivatives as a cell recognition marker. Dendrimers are important polymers having controlled chemical structure with a core, branches and surface sectors, which are designed and synthesized independently. We have already presented drug and gene delivery systems based on sugar balls, which have sugar moieties at the surface of the dendrimer backbone. In the present study, aliphatic polyethersareappliedtothesugar-substituteddendrimersin order to increase biocompatibility and decrease toxicity. The inside poly(ethylene glycol) dendrimer was synthesized by stepwise convergent method. The structure of the polyether dendrimers was well characterized using NMR, IR, UV, MALDI-TOF MS, and SEC analyses. The intersugar distance and molecular recognition ability was affected by changing sugar residues such as N-acetyl-D-glucosamine, D-galactose and lactose derivatives. Relationship between the chemical structure and molecular recognition ability was discussed in relation to biomaterials design using globular dendrimer skeleton.

本论文主要研究了一种新型的以糖衍生物为细胞识别标记物的树状高分子纳米材料的设计、合成和分子识别。树枝状大分子是一类具有可控化学结构的重要聚合物，具有核、支链和表面部分，可以独立设计合成。我们已经提出了基于糖球的药物和基因递送系统，其在树枝状聚合物主链的表面具有糖部分。在本研究中，脂肪族聚醚被应用于糖取代的树枝状聚合物，以增加生物相容性和降低毒性。采用逐步收敛法合成了内聚乙二醇树枝状大分子。采用NMR、IR、UV、MALDI-TOF MS和SEC分析对聚醚树枝状大分子的结构进行了表征。改变糖基如N-乙酰基-D-氨基葡萄糖、D-半乳糖和乳糖衍生物的结构，会影响糖间距离和分子识别能力。讨论了球形树枝状大分子的化学结构与分子识别能力之间的关系，并结合球形树枝状大分子骨架的生物材料设计进行了讨论。