Design of nano-capsules having controlled degradability by dendrimer precision synthesis.

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In the present project, we successfully synthesized an aliphatic polyester dendrimer using AB2-type building blocks prepared by Michael addition of denzyl acetoacetate to t-butyl acrylate, followed by reduction and by deprotection of the t-butyl groups. The aliphatic polyester dendrimer is a candidate of smart nano-materials having controlled degradability and release function of low-molecular-weight compounds.We also syntesized a new type of thermoresponsive star-type dendrimers having oligo(2-isopropyl-2-oxazoline) side chains and oligo(2-alkyl-2-oxazoline) terpolymer side chains, by precision polymer syntheses. Lower critical solution temperatures (LCSTs) and release profiles of the loaded low-molecular-weight compounds of the resulting star-type dendrimers are successfully controlled with changing the chemical structure, especially the arm structure. These star-type dendrimers are useful functional nano-materials in biochemical and biomedical fields.