Development of a 10 nm gap DNA electric tester and investigation of electric elements based on DNA molecules
Development of a 10 nm gap DNA electric tester and investigation of electric elements based on DNA molecules
批准号:
16360177
负责人:
HASHIGUCHI Gen
金额:
$9.73万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2004
资助国家:
日本
项目状态:
已结题
起止时间:
2004 至 2006
中文摘要
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英文摘要
The aim of this study is to develop a DNA electric tester having a 10 nm gap between two electric probes and investigation of electric elements using DNA testers. To form such a small gap with good reproducibility, a kind of the small-gap detection mechanism should be implemented for probe fabrication process. For this purpose, a new fabrication method of a narrow gap DNA tester has been developed. In order to detect the formation of a small gap between a pair of probes during silicon etching, current flow though the two probes was monitored. In this etching, only the tips of the probe structure are dipped into a KOH solution while AC power is applied between the two probes. The applying current heat up at the narrowest part of the silicon structure locally, resulting in silicon etching locally. When a gap is formed, the current is dropped since the current pass is broken. The local heating will hence finished, eventually stopping the etching. Using this method, approximately 50 nm gap DNA tweezers could be fabricated. Successive Al film deposition will make the gap smaller.Using the developed DNA testers and more wider gap DNA testers, electrical properties of DNA bundle were examined. The reproducible and explicit result is humidity dependency. We found that electrical conductance of DNA bundles is strongly affected by humidity. This result is consistent with literatures reported by other researchers.Furthermore, we have developed a Pd coated DNA wire and measured its electrical characteristics. The wire showed the electrical resistively of approximately 74 ohm-cm. Even in vacuum and at very low temperature (up to 77K), the current flow was observed for the DNA-Pd wire. Since the effect of humidity will be eliminated in this case, the current flow was supposed to be in the coated Pd layer.
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The Manipulation of Actin Filaments and Microtubules with Micromachined Nanotweezers
用微机械纳米镊子操纵肌动蛋白丝和微管
DOI:
--
发表时间:
2006
期刊:
Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology
影响因子:
--
作者:
[M.Hosogi, G.Hashiguchi, S.Shimamoto, N.Araki, H.Tokumitsu, R.Kobayashi]
通讯作者:
R.Kobayashi
Silicon Nanotweezers with Adjustable Gap for the Manipulation and Characterzation of DNA Molecules
用于 DNA 分子操作和表征的可调节间隙硅纳米镊子
DOI:
--
发表时间:
2006
期刊:
Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology
影响因子:
--
作者:
[C.Yamahata, T.Takekawa, K.Ayano, M.Hosogi, M.Kumemura, B.Legrand, D.Collard, G.Hashiguchi, H.Fujita]
通讯作者:
H.Fujita
Narrow Gap DNA Tweezers for Retrieval of Short Strand DNAs
用于检索短链 DNA 的窄间隙 DNA 镊子
DOI:
--
发表时间:
2004
期刊:
PROCEEDINGS OF THE 21ST SENSOR SYMPOSIUM
影响因子:
--
作者:
[J.Yamamoto, K.Tamura^*, K.Kakushima^*, M.Hosogi, G.Hashiguchi, H.Fujita^*]
通讯作者:
H.Fujita^*
Silicon Nanotweezers with Adjustable Gap for the Manipulation and Characterization of DNA Molecules
用于 DNA 分子操作和表征的可调节间隙硅纳米镊子
DOI:
--
发表时间:
2006
期刊:
Proceedings of 2006 International Conference on Microtechnologies in Medicine and Biology
影响因子:
--
作者:
[C.Yamahata, T.Takekawa, K.Ayano, M.Hosogi, M.Kumemura, B.Legrand, D.Collard, G.Hashiguchi, H.Fujita]
通讯作者:
H.Fujita
DOI:
10.1143/jjap.44.l955
发表时间:
2005-01-01
期刊:
JAPANESE JOURNAL OF APPLIED PHYSICS PART 2-LETTERS & EXPRESS LETTERS
影响因子:
--
作者:
[Hosogi, M, Hashiguchi, G, Fujita, H]
通讯作者:
Fujita, H
Development of a micro vibration energy harvesting device using silicon dioxide electret film including alkali ions
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批准号:23560287
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.41万
-
财政年份:2011
-
负责人:HASHIGUCHI Gen
-
依托单位:
Development of MEMS tweezers with atomic force sensing function for soft material handling
-
批准号:19310089
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.49万
-
财政年份:2007
-
负责人:HASHIGUCHI Gen
-
依托单位: