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Physiological polymorphisms on sebaceous gland activity in human

人体皮脂腺活性的生理多态性

基本信息

批准号：
16370105
负责人：
IMAMURA Ritsuko
金额：
$ 6.78万
依托单位：
Wakayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

Twenty-eight male volunteers aged 18-23 years old were divided into 3 groups at random. The first group (C) consisted of 9 persons wore full body cotton underwear every night for 4 weeks in autumn, the second group (P) consisited of 9 persons wore similar polyester underwear for an identical period, and the third group (AC) consisted of 10 persons wore a cotton (60%), polyester (20%) and biscose (20%) blended underwear. The hygroscopicity of these 3 underwear is 7.75, 0.63, and 6.46%, respectively. We collected sebum from their back skin once in the morning every week by a cup method using organic solvents. The chromatograms were developed and then charred, and the lipid classed were quantified by densitometry (Shimazu, CS-9300PS). The amounts of squalene (SQ), wax ester (WE), and triglycerides (TG) were calculated from the ratio of the peak area. The rate of concentrations of WE and TG increased gradually in cotton underwear to 162% and 132%, respectively until the 3rd week of the experiment, while those for polyester underwear increased once until the second week, but later they decreased to 78% and 80%, respectively, at the end of the experiment which was less than in cotton underwear. The result of the blended underwear (AC) was obtained between cotton and polyester underwear. There was no tendency in the result of SQ data among the 3 different kinds of materials. As a result, synthetic clothing with hydrophobic properties seems to suppress natural sebaceous gland activity from autumn to winter compared with that with hydrophilic properties. The results also suggest that synthetic clothing may possibly disturb natural physiological variations and the polyester clothes with hydrophobic properties would make the body more stressful, compared with cotton clothes with hydrophobic ones. However, the urine catecolamines showed no such tendency among the underwear materials.

28名年龄在18-23岁的男性志愿者被随机分为3组。第一组(C)有9人在秋季的4周内每晚穿着全棉内衣，第二组(P)有9人在相同的时间内穿着类似的聚酯内衣，第三组（AC）有10人穿着棉（60%）、聚酯（20%）和聚酯（20%）混纺内衣。这3款内衣的吸湿率分别为7.75%、0.63%、6.46%。我们每周早上一次用杯法用有机溶剂从他们的背部皮肤收集皮脂。将色谱进行显像，然后炭化，用密度法（Shimazu, CS-9300PS）定量脂质分类。角鲨烯（SQ）、蜡酯（WE）和甘油三酯（TG）的含量由峰面积的比值计算。棉质内衣WE和TG的浓度率在实验第3周逐渐上升，分别达到162%和132%，而涤纶内衣WE和TG的浓度率在实验第2周上升一次，但在实验结束时分别下降到78%和80%，低于棉质内衣。得到了棉、涤混纺内衣（AC）的结果。3种不同材料的SQ数据结果没有明显的趋势性。因此，与具有亲水性的合成服装相比，具有疏水性的合成服装似乎在秋季到冬季抑制天然皮脂腺活动。研究结果还表明，合成纤维服装可能会干扰人体的自然生理变化，而具有疏水性能的聚酯服装比具有疏水性能的棉质服装对人体的压力更大。而尿中儿茶酚胺在内衣材料中没有这种趋势。