Employing smart underwear to measure gut microbial hydrogen sulfide production
利用智能内衣测量肠道微生物硫化氢的产生量
基本信息
- 批准号:10425072
- 负责人:
- 金额:$ 22.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-06-10 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAffectAnogenital regionBiological AvailabilityCaloriesClinical TrialsCohort StudiesCollectionColorectal CancerComplexCoupledCysteineDevicesDietDietary FactorsDietary InterventionDiseaseEnzymesEtiologyFiltrationFlatulenceFutureGasesGoalsHealthHumanHydrogenHydrogen SulfideIn VitroIntakeMeasurementMeasuresMetabolismMethaneMethodsMiniaturizationNoiseNutrientOutcomeParticipantPhasePhysiologicalPhysiologyPlayProductionRandomizedResearchRoleSignal TransductionSignaling MoleculeSourceSystemTechniquesTestingTimeUlcerative ColitisValidationarmcomparison interventiondesigndietaryexperiencefeedingflexibilitygut microbiotahuman microbiotametal oxidemicrobialmicrobiomeminiaturized deviceprecision nutritionprototyperectalsensorsoftware developmenttemporal measurementtrimethylaminewearable device
项目摘要
PROJECT SUMMARY/ABSTRACT
The circulating gasotransmitter H₂S is endogenously produced by tightly-regulated human enzymes and
exogenously produced in a diet-dependent manner by the human microbiota. Exogenous H2S production by
the human gut microbiota influences human health by modulating systemic H2S bioavailability. Excessive gut
microbial H2S production is hypothesized to be involved in the etiology of colorectal cancer and Ulcerative
Colitis. Our understanding of how gut microbially produced H₂S affects human health remains incomplete
because current measurement techniques are imprecise, invasive, require biospecimen collection, and have
limited temporal resolution. In this proposal, our objective is to address this gap by developing a research-
grade wearable Smart Underwear device that enables long-term real time measurements of gut microbial H₂S
production in gaseous rectal effluent (flatus). Flatus are an untapped source for measuring gut microbial H2S
production. We have demonstrated that the Smart Underwear v1 prototype can precisely measure
physiologically-relevant concentrations of H2S in vitro. When worn by humans, the Smart Underwear v1
prototype detects flatus with an excellent signal-to-noise ratio and is able to estimate the concentration of H2S
in each flatus. In the R21 phase, we propose to develop a second revision Smart Underwear prototype for
clinical trials through miniaturization, software development, and incorporation of flexible materials. In addition,
we propose to conduct a user experience trial to gauge the user acceptance and test the reliability of the Smart
Underwear device when worn by humans. In the R33 phase, we will use the Smart Underwear v2 prototype
developed in the R21 phase to test the hypothesis that the Smart Underwear device can detect diet-induced
alterations in gut microbial H2S production using a randomized controlled feeding trial that contrasts gut
microbial H₂S production by modulating dietary cysteine intake. The completion of the proposed goals will lead
to the first wearable device that enables long-term real time measurements of gut microbial H2S production.
This will facilitate the design of personalized dietary interventions to rationally modulate gut microbial H₂S
production and benefit future studies seeking to untangle the complex interactions between gut microbial H2S
production and disease.
项目总结/摘要
循环气体传递素H β S由严格调节的人类酶内源性产生,
由人类微生物群以饮食依赖的方式外源产生。外源H2S的产生
人类肠道微生物群通过调节全身H2S生物利用度来影响人类健康。肠道过多
微生物H2S的产生被假设参与结肠直肠癌和溃疡性结肠炎的病因学。
结肠炎。我们对肠道微生物产生的H2S如何影响人类健康的理解仍然不完整
因为当前的测量技术是不精确的、侵入性的、需要生物样本收集,并且
有限的时间分辨率在这项建议中,我们的目标是通过开发一项研究来解决这一差距-
一种可穿戴的智能内衣设备,能够长期真实的时间测量肠道微生物的硫化氢
气体直肠流出物(肠胃气)中的产生。肠胃气是测量肠道微生物H2S的未开发来源
生产我们已经证明,智能内衣v1原型可以精确测量
H2S的体外生理相关浓度。当被人类穿着时,智能内衣v1
原型以出色的信噪比检测肠胃气,并能够估计H2S的浓度
在每一次放屁。在R21阶段,我们建议开发第二版智能内衣原型,
通过微型化、软件开发和柔性材料的结合进行临床试验。此外,本发明还提供了一种方法,
我们建议进行使用者体验试验,以评估使用者的接受程度和测试智能
内衣装置时,穿的人。在R33阶段,我们将使用智能内衣v2原型
在R21阶段开发,以测试智能内衣设备可以检测饮食诱导的假设
使用随机对照喂养试验改变肠道微生物H2S产生,
通过调节饮食半胱氨酸摄入量来产生微生物H2S。完成拟议目标将导致
到第一个能够长期真实的时间测量肠道微生物H2S产生的可穿戴设备。
这将有助于设计个性化的饮食干预措施,以合理调节肠道微生物的H.
未来的研究寻求解开肠道微生物H2S之间复杂的相互作用,
生产和疾病。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Reza Ghodssi其他文献
Reza Ghodssi的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Reza Ghodssi', 18)}}的其他基金
Employing smart underwear to measure gut microbial hydrogen sulfide production
利用智能内衣测量肠道微生物硫化氢的产生量
- 批准号:
10641753 - 财政年份:2022
- 资助金额:
$ 22.82万 - 项目类别:
Microsystem Development for Clozapine Monitoring in Schizophrenia
精神分裂症氯氮平监测的微系统开发
- 批准号:
9013503 - 财政年份:2015
- 资助金额:
$ 22.82万 - 项目类别:
相似海外基金
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
- 批准号:
BB/Z514391/1 - 财政年份:2024
- 资助金额:
$ 22.82万 - 项目类别:
Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
- 批准号:
2312555 - 财政年份:2024
- 资助金额:
$ 22.82万 - 项目类别:
Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
- 批准号:
2327346 - 财政年份:2024
- 资助金额:
$ 22.82万 - 项目类别:
Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
- 批准号:
ES/Z502595/1 - 财政年份:2024
- 资助金额:
$ 22.82万 - 项目类别:
Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
- 批准号:
ES/Z000149/1 - 财政年份:2024
- 资助金额:
$ 22.82万 - 项目类别:
Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
- 批准号:
23K24936 - 财政年份:2024
- 资助金额:
$ 22.82万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
- 批准号:
2901648 - 财政年份:2024
- 资助金额:
$ 22.82万 - 项目类别:
Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
- 批准号:
488039 - 财政年份:2023
- 资助金额:
$ 22.82万 - 项目类别:
Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
- 批准号:
23K00129 - 财政年份:2023
- 资助金额:
$ 22.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
- 批准号:
2883985 - 财政年份:2023
- 资助金额:
$ 22.82万 - 项目类别:
Studentship














{{item.name}}会员




