Development of a new assay system for protein S/protein C and treatment of thrombophilia.

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Coagulation factor V Leiden has not been detected in Japanese patients suffering from thromboses. We have performed a systematic investigation to find out genetic risk factors for thromboses in Japanese population. Our study indicates that the frequency (19/85=0.22) of mutations of protein S gene in the Japanese patients was 5-10 times higher than that of mutations of protein S gene in Caucasian patients, and the frequency (8/85=0.09) of mutations of protein C gene was almost three times higher than that of Caucasian patients, suggesting that Protein S/Protein C anomaly is the major risk factor for Japanese thrombophilia. During this study, we established a new quantitative method for Protein S/Protein C function. In addition, we found special components, which activate Protein S/Protein C activities. Now, we have tried to apply these components for the treatment of thromboses.