Effect of non-digestible and/or non-absorbable oligosaccharide on the prevention for infectious diarrhea among children with malnutrition.

为了阐明低聚果糖摄入对营养不良和感染性腹泻儿童生长、发育和腹泻等的影响，我们于2004年11月至2005年6月在孟加拉国达卡的ICDDR进行了为期6个月的调查。将150例2 ~ 4岁儿童分为两组，一组为FOS （2g）组，另一组为安慰剂（葡萄糖1g）组。这些糖溶解在50ml ORS中。现场工作人员每天到每个被试儿童的家中直接发放，并与被试儿童的母亲就腹泻情况、食物摄入情况和身体状况进行访谈。每2天测量体重1次，每月测量体长1次。结果，尽管食用FOS没有显著改善感染性腹泻，但腹泻的时间和频率显著改善（热带医学与卫生43:2006）。此外，还测量了短暂性腹泻的最大无效剂量水平…更多关于木糖醇、乳醇和红糖醇的健康受试者（J nutrition Sci Vitaminol 53-2006）。此外，有研究表明，通过同时摄入膳食纤维，如黄胶、海藻酸钠和纤维素，可以抑制摄入充足的不易消化的低聚糖引起的短暂性腹泻（Eur J clinin nur [Epuh ahead of print]）。此外，为了弄清作为食物原料开发的几种不可消化低聚糖的特性及其代谢和生理功能的差异，我们用含有FOS、冰糖、乳果糖或异聚寡糖的饲料饲养大鼠4-6周，观察其益生元效应。低聚糖的消化率和发酵率与肠道对钙和镁的吸收有关（J Japanese Soc nur Food science, press 60）。此外，研究表明肠道菌群和短链脂肪酸的产生与摄入足够的难消化低聚糖引起的短暂性腹泻的恢复呈交叉相关

In order to clarify the effects of fructooligosaccharide ingestion on growth, development, and diarrhea et al. of children with malnutrition and infectious diarrhea, we investigated with ICDDR, Bangladesh at the slam of Dahka for 6 months, from Nov. 2004 to June 2005. 150 children of 2-4 years old were divided to two groups, one group was FOS (2g) group and other was placebo (glucose 1g) group. These saccharides were dissolved in 50 mL of ORS. The fieldworkers visited to the home of each child subject every day to directly give it to them and interviewed to their mothers about the condition of diarrhea, food intake and body condition. Body weight was measured once per 2 days and length was measure once per month. As a result, although the infectious diarrhea was not significantly improved by FOS ingestion, the period and frequency of diarrhea were significantly improved (Tropical Medicine and Health 43 : 2006). Also, maximal non-effective dose level for transitory diarrhea was measured … More on xylitol, lactitol and erythritol using healthy human subjects (J Nutr Sci Vitaminol 53-2006). Furthermore, It has been demonstrated that transitory diarrhea by sufficient intake of non-digestible oligosaccharides was suppressed by simultaneous ingestion of dietary fibers such as gar gum, alginate-Na and cellulose (Eur J Clin Nutr [Epuh ahead of print]. In the addition, to clarify the characteristics and difference of metabolism and physiological functions of some kinds of non-digestible oligosaccharides developed as food materials, rats were raised with the diets containing FOS, glactosylsucrose, lactulose or isomatooligosaccharide for 4-6 weeks and observed the prebiotic effect. The digestibility and fermentability of oligosaccharides were concerned with the intestinal absorption of Ca and Mg (J Japanese Soc Nutr Food Sci 60 in press). Furthermore, it has demonstrated that intestinal microflora and the production of short chain fatty acids were crossly associated with the recovery of transitory diarrhea induced by sufficient intake of nondigestible oligosaccharides Less