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Effect of non-digestible and/or non-absorbable oligosaccharide on the prevention for infectious diarrhea among children with malnutrition.

不可消化和/或不可吸收的低聚糖对预防营养不良儿童感染性腹泻的作用。

基本信息

批准号：
16390184
负责人：
OKU Tsuneyuki
金额：
$ 9.34万
依托单位：
Siebold University of Nagasaki
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

项目摘要

In order to clarify the effects of fructooligosaccharide ingestion on growth, development, and diarrhea et al. of children with malnutrition and infectious diarrhea, we investigated with ICDDR, Bangladesh at the slam of Dahka for 6 months, from Nov. 2004 to June 2005. 150 children of 2-4 years old were divided to two groups, one group was FOS (2g) group and other was placebo (glucose 1g) group. These saccharides were dissolved in 50 mL of ORS. The fieldworkers visited to the home of each child subject every day to directly give it to them and interviewed to their mothers about the condition of diarrhea, food intake and body condition. Body weight was measured once per 2 days and length was measure once per month. As a result, although the infectious diarrhea was not significantly improved by FOS ingestion, the period and frequency of diarrhea were significantly improved (Tropical Medicine and Health 43 : 2006). Also, maximal non-effective dose level for transitory diarrhea was measured … More on xylitol, lactitol and erythritol using healthy human subjects (J Nutr Sci Vitaminol 53-2006). Furthermore, It has been demonstrated that transitory diarrhea by sufficient intake of non-digestible oligosaccharides was suppressed by simultaneous ingestion of dietary fibers such as gar gum, alginate-Na and cellulose (Eur J Clin Nutr [Epuh ahead of print]. In the addition, to clarify the characteristics and difference of metabolism and physiological functions of some kinds of non-digestible oligosaccharides developed as food materials, rats were raised with the diets containing FOS, glactosylsucrose, lactulose or isomatooligosaccharide for 4-6 weeks and observed the prebiotic effect. The digestibility and fermentability of oligosaccharides were concerned with the intestinal absorption of Ca and Mg (J Japanese Soc Nutr Food Sci 60 in press). Furthermore, it has demonstrated that intestinal microflora and the production of short chain fatty acids were crossly associated with the recovery of transitory diarrhea induced by sufficient intake of nondigestible oligosaccharides Less

为了解低聚果糖对营养不良和感染性腹泻儿童生长发育和腹泻等的影响，我们于2004年11月至2005年6月在达卡大满贯对孟加拉国ICDDR进行了为期6个月的调查。将150名2-4岁儿童随机分为两组，一组为FOS（2g）组，另一组为安慰剂（葡萄糖1g）组。将这些缓冲液溶于50 mL ORS中。现场工作人员每天访问每个儿童受试者的家，直接给他们，并采访他们的母亲，了解腹泻情况，食物摄入量和身体状况。每2天测量一次体重，每月测量一次身长。结果，尽管通过摄入FOS感染性腹泻没有显著改善，但腹泻的时间和频率显著改善（Tropical Medicine and Health 43：2006）。此外，还测量了暂时性腹泻的最大无效剂量水平 ...更多信息对木糖醇、乳糖醇和木糖醇的影响（J Nutr Sci Vitaminol 53-2006）。此外，已经证明，通过同时摄入膳食纤维如琼脂糖、藻酸钠和纤维素，抑制了通过摄入足够的不可消化的低聚糖引起的暂时性腹泻（Eur J Clin Nutr [Epuh ahead of print].此外，为了阐明几种非消化性低聚糖作为食品原料的代谢和生理功能的特点和差异，用含低聚果糖、半乳糖基蔗糖、乳果糖和异低聚果糖的饲料饲养大鼠4-6周，观察其益生素效应。低聚糖的消化率和发酵率与肠道对钙和镁的吸收有关（J Japanese Soc Nutr Food Sci 60 in press）。此外，已经证明肠道微生物菌群和短链脂肪酸的产生与摄入足够的不可消化的寡糖引起的暂时性腹泻的恢复交叉相关。