Study on the mechanism of development of differentiated adenocarcinoma from intestinal metaplasia

肠化生分化型腺癌发生发展机制的研究

• 批准号: 16390214
• 负责人: SUGANO Kentaro
• 金额: $ 9.22万
• 依托单位: JICHI MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390214/
• 关键词: Intestinal Metaplasia; Gastric Cancer; Transgenic mouse; Transcriptional Factor; Cdx1, 2; Math 1; Sonic Hedgehog; 分化型胃癌; CDX; SHH

Intestinal metaplasia has been considered as a condition predisposing cancer development.However, no direct evidence on cancer development from intestinal metaplasia has been provided.In this research project, we could demonstrate that gastric adenocarcinoma with differentiated histological features developed from intestinal metaplasia in the cdx-2 expressing transgenic mice stomach. The analysis of genetic alteration revealed that mutational events frequently observed in human gastric cancer (such as p53 or APC gene mutations or truncations) occurred in the mice tumors. Therefore, this model will be quite useful for analyzing the molecular events leading to carcinogenesis and also for interventional studies to suppress cancer development.

肠化生被认为是一种易导致癌症发展的疾病。然而，没有直接证据表明肠化生会导致癌症。在本研究项目中，我们可以证明在表达cdx-2的转基因小鼠胃中，由肠化生发展成具有分化组织学特征的胃腺癌。基因改变分析显示，人类胃癌中常见的突变事件（如p53或APC基因突变或截断）也发生在小鼠肿瘤中。因此，该模型对于分析导致癌变的分子事件以及抑制癌症发展的介入性研究将非常有用。

项目成果

Development of gastric carcinoma from intestinal metaplasia in CDx2-transgenic mice

• DOI: 10.1158/0008-5472.can-04-1617
• 发表时间: 2004-11-01
• 期刊: CANCER RESEARCH
• 影响因子: 11.2
• 作者: Mutoh, H;Sakurai, S;Sugano, K
• 通讯作者: Sugano, K

Histamine-2 receptor expression in gastric mucosa before and after Helicobacter pylori cure.

幽门螺杆菌治愈前后胃粘膜组胺-2受体表达。

• 发表时间: 2005
• 期刊: Aliment.Pharmacol.Ther. 21(Suppl.2)
• 作者: H.Osawa;H.Mutoh;K.Satoh;K.Sugano;et al.
• 通讯作者: et al.

The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Math1

• DOI: 10.1111/j.1432-0436.2006.00074.x
• 发表时间: 2006-07-01
• 期刊: DIFFERENTIATION
• 影响因子: 2.9
• 作者: Mutoh, H;Sakamoto, H;Sugano, K
• 通讯作者: Sugano, K

The intestine-specific homeobox gene Cdx2 induces expression of the basic helix-loop-helix transcription factor Mathl

肠道特异性同源框基因 Cdx2 诱导碱性螺旋-环-螺旋转录因子 Mathl 的表达

• 发表时间: 2006
• 期刊: Differentiation (in press)
• 作者: Hiroyuki Mutoh;Hirotsugu Sakamoto;Hiroko Hayakawa;Yukitomo Aroa;Kiichi Satoh;Mitsuhiro Nokubi;Kentaro Sugano
• 通讯作者: Kentaro Sugano

Cdx1 induced intestinal metaplasia in the transgenic mouse stomach: comparative study with Cdx2 transgenic mice

• DOI: 10.1136/gut.2003.032482
• 发表时间: 2004-10-01
• 期刊: GUT
• 影响因子: 24.5
• 作者: Mutoh, H;Sakurai, S;Sugano, K
• 通讯作者: Sugano, K