A comprehensive study on laryngeal neuroregulation and it's dysfunction

喉神经调节及其功能障碍的综合研究

• 批准号: 16390492
• 负责人: HISA Yasuo
• 金额: $ 8.96万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390492/
• 关键词: larynx; neuronal regulation system; TRPV; α-gustducin; FGF1; TAF II 250; airway clock genes; 中枢性投射; 知覚受容器; 過誤神経支配; 基本転写因子; 痙攣性発声障害; transsynaptic tracer; コリン作動性神経; 知覚受容体; 衛星細胞; 時計遺伝子; 疑核; 節状神経節

Laryngeal neuroregulation is essential in such functions as respiration, deglutition and phonation, which are vital for human survival and social participation. One of the primary objects of laryngeal research has been to seek a better understanding of the laryngeal nervous system. Our knowledge has advanced considerably through research in the past, but much is still poorly understood, and advances in scientific technology has revealed new issues to be studied. The present is a comprehensive and systematic study on the following contemporary issues, using and combining various methods.1.Localization of TRPV1 and TRPV2 in laryngeal sensory neurons.2.Expression and age related changes in expression of α-gustducin in the larynx.3.Expression of FGF1 in the dorsal nucleus of the vagal nerve and nucleus hypoglossus.4.Expression of FGF1 in cholinergic neurons innervating the larynx.5.Expression of TAF-250 in the laryngeal innervation.6.Expression and vagal control of clock genes in the airway.

喉神经调节在呼吸，脱水和发声等功能中至关重要，这对于人类的生存和社会参与至关重要。喉研究的主要对象之一是寻求对喉神经系统的更好理解。过去的研究已经仔细地提高了我们的知识，但是许多人的知识仍然知之甚少，科学技术的进步揭示了要研究的新问题。目前是对以下当代问题的全面，系统的研究，使用和结合各种方法。1。喉部感觉神经元中TrPV1和TRPV2的局部化。2。larynx.3. larynx的表达和年龄相关的α-峰蛋白表达的变化。3。FGF1表达FGF1在fgf1的表达中，fgf1的表达是highal nath y hived4. actal nuclus nifoss y hived4. hived4. hived4. hived4. hived4. hived4. hived4. hived4. hived4. hived4. hived4. hived4.胆碱能神经元支配喉。5。喉神经支配中TAF-250的表达。6。气道中时钟基因的表达和迷走神经控制。

项目成果

Age-related expression of a-gustducin in the rat larynx.

大鼠喉中 a-gustducin 的年龄相关表达。

• 发表时间: 2006
• 期刊: Ann Otol Rhinol Laryngol 115-5
• 作者: Nishio T;et al.
• 通讯作者: et al.

Immunohistochemical study of TAF II 250 in the rat laryngeal nervous system.

TAF II 250 在大鼠喉神经系统中的免疫组织化学研究。

• 发表时间: 2005
• 期刊: Hitol Histopathol 20・4
• 作者: Okano H;et al.
• 通讯作者: et al.

Age-related expression of α-gustducin in the rat larynx.

大鼠喉中 α-gustducin 的年龄相关表达。

• 发表时间: 2006
• 期刊: Ann Otol Rhinol Laryngol 115・5
• 作者: Nishio T;et al.
• 通讯作者: et al.