A cohort study on cancer mortality among Chinese iron-steel workers

在本研究的两个目的中，中国钢铁工人的第二次随访不可避免地被暂停并最终放弃，因为1994年以来，随着中国时代的发展，钢铁公司进行了重组和裁员，身份证号码和人事管理制度完全改变，无法进行。尽管与中国研究人员讨论了几种替代方法，例如对原始的亚队列进行随访。另一个目的，即在原始队列中重新分析暴露于15种有害物质的死亡风险。对总共121,846名男性和25,216名女性的进一步分析提供了一些有意义的结果。与鞍山普通人群相比，所有死亡率、癌症死亡率和其他死亡率的标准化死亡率（SMR）随着钢铁环境暴露水平的增加呈上升趋势，尽管由于健康工人的影响，SMR显著低于零值。所有死亡率、癌症死亡率和几个癌症地点的标准化风险比（SRR）表明，与未接触这些因素的蓝领工人相比，接触这些因素的工人的死亡风险更高。特别是，同时暴露于包括多环芳烃（PAH）在内的多种因素的工人，其所有死亡率、癌症死亡率、脑血管和心血管死亡率的srr都明显更高。与美国、英国、巴西等国的文献报道相比，本研究的特点是队列规模更大，随访率（98.1%）更高，且研究对象为女性劳动者，在职业卫生领域具有一定的研究价值。（包括2篇学术期刊论文和10篇科学会议研究报告）（281字）

Of two aims in this study, the second follow-up of Chinese iron-steel workers had to be inevitably suspended and consequently given up because the iron-steel company had been restructured and downsized since 1994 with the current of the times in China The ID number and personnel management system was totally changed and made it unable to be conducted., although several alternative methods were discussed with Chinese researchers such as a follow-up of sub-cohort of the original. The other purpose, i.e., mortality risk of exposures to fifteen hazardous agents was re-analyzed in the original cohort Further analyses with a total of 121, 846 males and 25, 216 females provide some meaningful results. SMR (standardized mortality ratio) for all mortality, cancer mortality and others showed increasing trend with the levels of exposure to iron-steel environment with reference to the general population in Anshan, China, although SMRs were significantly lower than null value because of the healthy workers effect. SRR (standardized risk ratio) for all mortality, cancer mortality and several sites of cancer indicated higher mortality risks among the workers with exposure to factors in iron-steel foundry with reference to the blue-collar workers without any exposures to the factors. In particular, the workers with combined exposure to several factors included PAH (polycyclic aromatic hydrocarbons) showed significantly higher SRRs for all mortality, cancer mortality, cerebrovascular and cardiovascular mortality. Compared with previous reports in US, UK, and Brazil, the characteristics in the study were larger in scale of the cohort, higher rate of follow-up (98.1%), and providing the results in female workers, which may be of great value in occupational health field. (Two publications in academic journals and ten research presentation in scientific meetings were included) (281 words)