Basic Research on Technical Methods of Risk Analysis for Developing Dementia with the use of Brain Waves

利用脑电波进行痴呆风险分析技术方法的基础研究

• 批准号: 16500169
• 负责人: KONNO Hidetoshi
• 金额: $ 1.97万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16500169/
• 关键词: brain wave; Risk for develoning dementia; characteristics of local fluctuations; extracting risk factor; denendency among multiple risk factors; Logistic regression; photo-stimulated brain wave; nonlinear response v. s. brain function; 周波数変調; 光刺激

The aim of this study is to find technical foundation of the risk analysis for developing dementia with the use of brain waves. Various statistical methods are examined for extracting available information for the diagnosis of developing dementia from fluctuations of brain waves. The results are summarized as shown below. (1) The method of extracting risk factors from spontaneous EEG based on the stochastic complex Ginzburg-Landau equation is established. The obtained facts by the method are listed as: (a) it is found that the frequency modulation of brain waves is subjected to a generalized Cauchy process; (b) the intermittency of frequency modulation can be ascribed to amplitude modulation via the effect of nonlinear pulling; c spatial homogenization of frequency modulation due to aging; (d) qualitative estimation of intermittency and its physical/physiological interpretation; (e) suggestion of " multiple-scattering scenario-due to brain-medium-change in developing dementia (2) Found … More ation of multiple risk factors associated with the developing dementia, and their dependencies: (a) dependency between mean frequency and its variance; (b) dependency between mean fractal dimension and its variance; c dependency between entropy and gradient of entropy as a function of scale; (d) examination of feasibility for Logistic regression method based on the examined risk factors. (3) Construction of Generalized Kubo oscillator for photo-stimulated EEG to examine brain functions: (a) proof of non-existence of entrainment for a modified Kubo oscillator, (b) examination of the existence of threshold of entrainment under photo stimulation, c examination of frequency modulation, (d) examination of higher order nonlinear responses; (e) implication of mechanism of parametric excitation in brain. (4) Results on statistical mathematical analysis on generalized Cauchy process: (a) foundation of non divergent statistical quantities in the parameter region wherein the ordinary variance diverges; (b) method of transformation from non canonical model into the canonical one; c proof far the equivalence of maximum likelihood estimator (MLE) estimator to the fluctuation-dissipation theorem; (d) explanation of profile change in the probability density (pdf) of frequency fluctuation for some demented persons; (e) exact analytic expression of the pdf and related WE with 3rd order nonlinear term in the white noise limit. Less

本研究的目的是寻找脑电波用于痴呆风险分析的技术基础。各种统计方法进行检查，从脑波波动中提取诊断发展中痴呆症的可用信息。结果总结如下。(1)建立了基于随机复Ginzburg-Landau方程的自发脑电危险因素提取方法。结果表明：（a）脑电波的频率调制服从广义柯西过程，（B）频率调制的不稳定性可归因于非线性牵引效应引起的振幅调制，（c）年龄对频率调制的空间均匀化，（d）不稳定性的定性估计及其物理/生理解释，（e）频率调制的不稳定性的物理/生理解释。（e）提出“发展中的痴呆症中的脑介质变化引起的多散射波”（2） ...更多信息 与发展中的痴呆症相关的多个危险因素及其依赖关系：（a）平均频率与其方差之间的依赖关系;（B）平均分形维数与其方差之间的依赖关系;（c）熵与熵梯度作为尺度的函数之间的依赖关系;（d）基于所检查的危险因素的Logistic回归方法的可行性检查。(3)构造用于光刺激脑电检测的广义Kubo振荡器：（a）证明改进的Kubo振荡器不存在夹带，（B）检测光刺激下夹带阈值的存在，（c）检测频率调制，（d）检测高阶非线性响应，（e）揭示脑内参数激发机制。(4)对广义Cauchy过程的统计数学分析结果：（a）在方差发散的参数区域内建立了不发散的统计量，（B）将非正则模型转化为正则模型的方法，（c）证明了极大似然估计（MLE）与涨落耗散定理的等价性，（d）证明了极大似然估计（MLE）与涨落耗散定理的等价性，（e）证明了极大似然估计与涨落耗散定理的等价性。（d）解释某些失智症患者的频率波动概率密度（pdf）的分布变化;（e）在白色噪声极限下，pdf和相关WE的精确解析表达式，其中包含三阶非线性项。少

项目成果

リスク工学概論

风险工程简介

• 发表时间: 2008
• 作者: H. Konno;H. Chatani;Y. Takahashi;A. Sakata and S. Tobimatsu;Hidetoshi Konno;H. Konno and H. Chatani;Hidetoshi Konno;Hidetoshi Konno and Fumitoshi Watanabe;H. Konno;H. Konno and F. Watanabe;Hidetoshi Konno and Kosuke Nishimura;Hidetoshi Konno and Kosuke Nishimura;金野秀敏
• 通讯作者: 金野秀敏

有色雑音と3次の非線形項を有する一般化コーシー過程の確率分布の近似解析解とモンテカルロシミュレーション

带有色噪声和三阶非线性项的广义柯西过程概率分布的近似解析解及蒙特卡洛模拟

• 发表时间: 2008
• 期刊: 統計数理研究所共同研究リポート 210
• 作者: Naoaki Bakki;Ken Kiyono and Hidetoshi Konno;金野 秀敏
• 通讯作者: 金野 秀敏

Characteristics of Intermittency for time series data generated From Physical Model of Thermomagnetic Convection(in Japanese)

热磁对流物理模型生成的时间序列数据的间歇性特征（日文）

• 发表时间: 2008
• 期刊: Report of ISM Vol.210
• 作者: Naoaki Bakki;Ken Kiyono and Hidetoshi Konno
• 通讯作者: Ken Kiyono and Hidetoshi Konno

Nonlinear Theory of Entrainment in EEG Under Photo-Stimulation by Periodic Rectangular Pulse

周期性矩形脉冲光刺激下脑电图夹带的非线性理论

• 发表时间: 2007
• 期刊: AIP Conference Proceedings Vol.922, Noise and Fluctuations
• 作者: H. Konno;H. Chatani;A. Sakata and S. Tobimatsu
• 通讯作者: A. Sakata and S. Tobimatsu

Theory of Frequency Modulation for Brain Waves and Applications(in Japanese)

脑电波调频原理及应用（日文）

• 发表时间: 2007
• 期刊: Report of ISM Vol.197
• 作者: H. Konno;H. Chatani;Y. Takahashi;A. Sakata and S. Tobimatsu;H. Konno;Hidetoshi Konno
• 通讯作者: Hidetoshi Konno